Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Lee A. Danielson"'
Publikováno v:
Journal of Applied Physiology. 98:1013-1020
We previously showed that chronic administration of recombinant human relaxin (rhRLX; 4 microg/h) to conscious female, nonpregnant rats to reach serum levels corresponding to early to midgestation (approximately 20 ng/ml) increases cardiac output (CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb2cd1781521a2424bdad7576630750
https://doi.org/10.1152/japplphysiol.01083.2004
https://doi.org/10.1152/japplphysiol.01083.2004
Publikováno v:
Endocrinology. 145:3289-3296
Relaxin emanates from the corpus luteum of the ovary and circulates during pregnancy. Because the hormone is a potent renal vasodilator and mediates the renal vasodilation and hyperfiltration of pregnancy in conscious rats, we reasoned that it might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7a9eddadb6144b9d9402158a28b305
https://doi.org/10.1210/en.2003-1612
https://doi.org/10.1210/en.2003-1612
Autor:
Shannon L. Opett, Lee A. Danielson, Arundhathi Jeyabalan, Kirk P. Conrad, Jacqueline Novak, Laurie J. Kerchner
Publikováno v:
Circulation Research. 93:1249-1257
During pregnancy, relaxin stimulates nitric oxide (NO)–dependent renal vasodilation, hyperfiltration and reduced myogenic reactivity of small renal arteries via the endothelial ET B receptor subtype. Our objective in this study was to elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957827bfe09224a92d9c7340f6b4bb61
https://doi.org/10.1161/01.res.0000104086.43830.6c
https://doi.org/10.1161/01.res.0000104086.43830.6c
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 279:R1298-R1304
Chronic administration of the hormone relaxin elicits renal vasodilation that is dependent on nitric oxide (NO) in both conscious intact and ovariectomized female rats. Our first objective was to test whether the hormone, when administered to approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f364d855b89dbd3694d8cec8beba40e
https://doi.org/10.1152/ajpregu.2000.279.4.r1298
https://doi.org/10.1152/ajpregu.2000.279.4.r1298
Autor:
Lee A. Danielson, Kirk P. Conrad
Publikováno v:
Journal of Clinical Investigation. 96:482-490
Because the kidneys are vasodilated and the endogenous production of nitric oxide is increased in gravid rats, we tested whether nitric oxide mediates the renal vasodilatory response to pregnancy. Chronically instrumented, conscious rats of gestation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd1ea0b7fd86e491ba6be198d8b7a0e
https://doi.org/10.1172/jci118059
https://doi.org/10.1172/jci118059
Publikováno v:
Journal of the American Society of Nephrology : JASN. 17(11)
Maternal renal hemodynamic adaptation to human pregnancy is one of the most dramatic of all physiologic changes, but the factors that are responsible have remained elusive. In rat pregnancy, there are comparable renal hemodynamic changes, and in this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fa2807ecf4369082b77dab4d069b54
https://pubmed.ncbi.nlm.nih.gov/17035603
https://pubmed.ncbi.nlm.nih.gov/17035603
Publikováno v:
Journal of the American Society of Nephrology : JASN. 17(5)
Administration of recombinant human relaxin (rhRLX) to conscious, chronically instrumented rats increases GFR and effective renal plasma flow (ERPF) and decreases effective renal vascular resistance (ERVR) with no significant change in mean arterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408ca4c1237098e8071d558affd112a5
https://pubmed.ncbi.nlm.nih.gov/16597680
https://pubmed.ncbi.nlm.nih.gov/16597680
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 46(4)
Chronic administration of recombinant human relaxin (rhRLX) to conscious, normotensive rats (male and female) increases cardiac output (CO) and global arterial compliance (AC g ) and reduces systemic vascular resistance (SVR) with no change in mean a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e88f3d724aad30ff5f401cf9246b12
https://pubmed.ncbi.nlm.nih.gov/16172427
https://pubmed.ncbi.nlm.nih.gov/16172427
Publikováno v:
Annals of the New York Academy of Sciences. 1041
Rat studies have convincingly demonstrated the essential role of the ovarian hormone relaxin in mediating gestational renal hemodynamic and osmoregulatory changes in that species. We describe a model in nonpregnant volunteers using exogenous hCG to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e4e94535fbeab97cade1b5a816552c
https://pubmed.ncbi.nlm.nih.gov/15956702
https://pubmed.ncbi.nlm.nih.gov/15956702
Publikováno v:
Fertility and sterility. 86(1)
Women with normal ovarian function (n = 9) and women who conceived with ovum donation (no circulating relaxin; n = 9) had serial measurements of renal function made during the first trimester of pregnancy by using 24-hour creatinine clearance (CrCl)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d62e101de5502fec8544daebf27e4c
https://pubmed.ncbi.nlm.nih.gov/16730722
https://pubmed.ncbi.nlm.nih.gov/16730722