Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lee A, Hodges"'
Publikováno v:
Pharmaceutical Research
Purpose To investigate the hypothesis that paracetamol is absorbed faster from a hot drink than from a standard tablet using simultaneous scintigraphic imaging and pharmacokinetic sampling. Methods Twenty-five healthy male volunteers received both pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6b870c5267147b78da18942a3363ae
https://doi.org/10.1007/s11095-014-1309-3
https://doi.org/10.1007/s11095-014-1309-3
Autor:
Manon F, Pritchard, Lydia C, Powell, Georgina E, Menzies, Paul D, Lewis, Karl, Hawkins, Chris, Wright, Iolo, Doull, Timothy R, Walsh, Edvar, Onsøyen, Arne, Dessen, Rolf, Myrvold, Philip D, Rye, Astrid H, Myrset, Howard N E, Stevens, Lee A, Hodges, Gordon, MacGregor, James B, Neilly, Katja E, Hill, David W, Thomas
Publikováno v:
Molecular pharmaceutics. 13(3)
The host- and bacteria-derived extracellular polysaccharide coating of the lung is a considerable challenge in chronic respiratory disease and is a powerful barrier to effective drug delivery. A low molecular weight 12-15-mer alginate oligosaccharide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8987df1b5bd8ab469c489a23e152e51
https://pubmed.ncbi.nlm.nih.gov/26833139
https://pubmed.ncbi.nlm.nih.gov/26833139
Autor:
S.M. Connolly, Thomas. J. Schmidt, John H. Winter, Lee Ann Hodges, Marshall Hayward, Clive G. Wilson, Howard N.E. Stevens
Publikováno v:
International Journal of Pharmaceutics. 432:57-62
Gastrointestinal side-effects of alendronate (ALN) are believed to be associated with oesophageal lodging of tablets and perhaps reflux of gastric contents with alendronate under strongly acidic pH conditions. This leads to unfavourable posture restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c822b8f81164a3886af14e934ebe84
https://doi.org/10.1016/j.ijpharm.2012.04.073
https://doi.org/10.1016/j.ijpharm.2012.04.073
Autor:
Janet Band, Lee Ann Hodges, Bridget O'Mahony, Howard N.E. Stevens, Manish Ghimire, Alexander B. Mullen, Fiona J. McInnes
Publikováno v:
Journal of Controlled Release. 147:70-75
The purpose of this study was to evaluate and compare the in-vitro and in-vivo erosion profiles of two tablet formulations primarily consisting of hydroxypropylmethylcellulose (HPMC) and lactose. HPMC was used at concentrations below and above the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b6f35d919fc024a6a85c87dc756295
https://doi.org/10.1016/j.jconrel.2010.06.015
https://doi.org/10.1016/j.jconrel.2010.06.015
Autor:
Clive G. Wilson, Howard N.E. Stevens, Janet Band, Kirsteen Goodman, Lee Ann Hodges, Werner Weitschies
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 74:84-92
Purpose To validate Magnetic Moment Imaging (MMI) for the investigation of gastrointestinal transit and disintegration of solid dosage forms and to correlate the MMI findings with the corresponding gamma scintigraphic data. Materials and methods Thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199d4530639b91b1c2c8aaec75c826b9
https://doi.org/10.1016/j.ejpb.2009.01.004
https://doi.org/10.1016/j.ejpb.2009.01.004
Autor:
Bridget O'Mahony, Howard N.E. Stevens, Clive G. Wilson, Murat Türkoğlu, Timuçin Uğurlu, S.M. Connolly, Lee Ann Hodges
Publikováno v:
International Journal of Pharmaceutics. 370:144-150
The in vivo evaluation of colon-targeting tablets was conducted in six healthy male volunteers. A pectin-hydroxypropyl methylcellulose coating was compressed onto core tablets labelled with 4MBq (99m)Tc-DTPA. The tablets released in the colon in all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5d94a65d701b68cf74562454c16b48
https://doi.org/10.1016/j.ijpharm.2008.12.002
https://doi.org/10.1016/j.ijpharm.2008.12.002
Autor:
Fiona J. McInnes, Bridget O’Mahony, Blythe Lindsay, Janet Band, Clive G. Wilson, Lee Ann Hodges, Howard N.E. Stevens
Publikováno v:
European Journal of Pharmaceutical Sciences. 31:25-31
Bioadhesive dosage forms are a potential method for overcoming rapid mucociliary transport in the nose. A lyophilised nasal insert formulation previously investigated in sheep demonstrated prolonged absorption of nicotine hydrogen tartrate suggestive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5154f36608776e3c826ff46ce02308b
https://doi.org/10.1016/j.ejps.2007.02.002
https://doi.org/10.1016/j.ejps.2007.02.002
Publikováno v:
Hydrophilic Matrix Tablets for Oral Controlled Release ISBN: 9781493915187
The complexity of the local environment of the gastrointestinal tract presents a significant challenge for achieving reliable performance of hydrophilic matrix oral dosages, and designing robustness into the formulation is key to achieving reproducib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051a42849d8320c7f821290a39914d64
https://doi.org/10.1007/978-1-4939-1519-4_12
https://doi.org/10.1007/978-1-4939-1519-4_12
Autor:
S.M. Connolly, Lee Ann Hodges, Howard N.E. Stevens, L.A. Creech, Sang Min Shim, K.A. Sime, S.T. Barclay, Hun Sik Wang, Jun Sang Park, Min Chang Kwon, Byeong Jin Jeon
Publikováno v:
International journal of pharmaceutics. 454(1)
Conventional modified release preparations of tamsulosin HCl have been linked to increased incidence of cardiovascular adverse events, possibly due to rapid drug peaks soon after ingestion. A ‘flattened’ absorption profile has been shown to reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ca7f91b5780b88db328101cab0bfcf
https://pubmed.ncbi.nlm.nih.gov/23834829
https://pubmed.ncbi.nlm.nih.gov/23834829
Autor:
Alistair Ross, Tamara Jones, Alastair J. Florence, Michael John Humphrey, Adrian J. Stanley, Janet Band, Bridget O'Mahony, Clive G. Wilson, Lee Ann Hodges, Jason T. McConville, Howard N.E. Stevens, Blythe Lindsay
Publikováno v:
Journal of pharmaceutical sciences. 98(11)
Three time-delayed capsule (TDC) formulations were investigated in a pharmacoscintigraphic study, using a three-way crossover design in eight healthy male volunteers. Additionally, the pulsed release of a TDC was investigated with time-lapse photogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c002ddab68869fca623b1cd1ebd4a91e
https://pubmed.ncbi.nlm.nih.gov/19387976
https://pubmed.ncbi.nlm.nih.gov/19387976