CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

Autor: Klomp, Jennifer E., Lee, Ye S., Goodwin, Craig M., Papke, Björn, Klomp, Jeff A., Waters, Andrew M., Stalnecker, Clint A., DeLiberty, Jonathan M., Drizyte-Miller, Kristina, Yang, Runying, Diehl, J. Nathaniel, Yin, Hongwei H., Pierobon, Mariaelena, Baldelli, Elisa, Ryan, Meagan B., Li, Siqi, Peterson, Jackson, Smith, Amber R., Neal, James T., McCormick, Aaron K., Kuo, Calvin J., Counter, Christopher M., Petricoin, Emanuel F., III, Cox, Adrienne D., Bryant, Kirsten L., Der, Channing J.

Publikováno v: In Cell Reports 30 November 2021 37(9)

VCP/p97, a pleiotropic protein regulator of the DNA damage response and proteostasis, is a potential therapeutic target in KRAS -mutant pancreatic cancer.

Autor: Lee YS; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Klomp JE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Stalnecker CA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Goodwin CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Gao Y; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Droby GN; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vaziri C; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bryant KL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cox AD; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Publikováno v: Genes & cancer [Genes Cancer] 2023 Mar 10; Vol. 14, pp. 30-49. Date of Electronic Publication: 2023 Mar 10 (Print Publication: 2023).