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Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.

Autor: Tang CM; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Lee TE; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Syed SA; Department of Physiology and Biomedical Engineering and Gastroenterology Research Unit, Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA., Burgoyne AM; Department of Medicine, Division of Hematology/Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Leonard SY; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Gao F; Department of Physiology and Biomedical Engineering and Gastroenterology Research Unit, Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Chan JC; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Shi E; School of Medicine, University of California, San Diego, La Jolla, California, USA., Chmielecki J; Foundation Medicine, Inc., Cambridge, Massachusetts, USA., Morosini D; Foundation Medicine, Inc., Cambridge, Massachusetts, USA., Wang K; Foundation Medicine, Inc., Cambridge, Massachusetts, USA., Ross JS; Foundation Medicine, Inc., Cambridge, Massachusetts, USA., Kendrick ML; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA., Bardsley MR; Department of Physiology and Biomedical Engineering and Gastroenterology Research Unit, Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA., Siena M; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA., Mao J; Department of Molecular, Cell and Cancer Biology, University of Massachusetts, Worchester, Massachusetts, USA., Harismendy O; Division of Biomedical Informatics, Moores UCSD Cancer Center, University of California San Diego, La Jolla, California, USA., Ordog T; Department of Physiology and Biomedical Engineering and Gastroenterology Research Unit, Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.; Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota, USA., Sicklick JK; Department of Surgery, Division of Surgical Oncology, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California, USA.; School of Medicine, University of California, San Diego, La Jolla, California, USA.

Publikováno v: Oncotarget [Oncotarget] 2016 Nov 29; Vol. 7 (48), pp. 78226-78241.