Prioritizing SNPs for Disease-Gene Association Studies: Algorithms and Systems

Autor: LEE, PHIL HYOUN

Identifying single nucleotide polymorphisms (SNPs) that are involved in common and complex diseases, such as cancer, is a major challenge in current molecular epidemiology. Knowledge of such SNPs is expected to enable timely diagnosis, effective trea

Externí odkaz: http://hdl.handle.net/1974/1965

Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p

Autor: Weiner, Daniel J., Ling, Emi, Erdin, Serkan, Tai, Derek J. C., Yadav, Rachita, Grove, Jakob, Fu, Jack M., Nadig, Ajay, Carey, Caitlin E., Baya, Nikolas, Bybjerg-Grauholm, Jonas, Mortensen, Preben B., Werge, Thomas, Demontis, Ditte, Mors, Ole, Nordentoft, Merete, Als, Thomas D., Baekvad-Hansen, Marie, Rosengren, Anders, Havdahl, Alexandra, Hedemand, Anne, Palotie, Aarno, Chakravarti, Aravinda, Arking, Dan, Sulovari, Arvis, Starnawska, Anna, Thiruvahindrapuram, Bhooma, de Leeuw, Christiaan, Carey, Caitlin, Ladd-Acosta, Christine, van der Merwe, Celia, Devlin, Bernie, Cook, Edwin H., Eichler, Evan, Corfield, Elisabeth, Dieleman, Gwen, Schellenberg, Gerard, Hakonarson, Hakon, Coon, Hilary, Dziobek, Isabel, Vorstman, Jacob, Girault, Jessica, Sutcliffe, James S., Duan, Jinjie, Nurnberger, John, Hallmayer, Joachim, Buxbaum, Joseph, Piven, Joseph, Weiss, Lauren, Davis, Lea, Janecka, Magdalena, Mattheisen, Manuel, State, Matthew W., Gill, Michael, Daly, Mark, Uddin, Mohammed, Andreassen, Ole, Szatmari, Peter, Lee, Phil Hyoun, Anney, Richard, Ripke, Stephan, Satterstrom, Kyle, Santangelo, Susan, Kuo, Susan, van Elst, Ludger Tebartz, Rolland, Thomas, Bougeron, Thomas, Polderman, Tinca, Turner, Tychele, Underwood, Jack, Manikandan, Veera, Pillalamarri, Vamsee, Warrier, Varun, Philipsen, Alexandra, Reif, Andreas, Hinney, Anke, Cormand, Bru, Bau, Claiton H. D., Rovaris, Diego Luiz, Sonuga-Barke, Edmund, Corfield, Elizabeth, Grevet, Eugenio Horacio, Salum, Giovanni, Larsson, Henrik, Buitelaar, Jan, Haavik, Jan, McGough, James, Kuntsi, Jonna, Elia, Josephine, Lesch, Klaus-Peter, Klein, Marieke, Bellgrove, Mark, Tesli, Martin, Leung, Patrick W. L., Pan, Pedro M., Dalsgaard, Soren, Loo, Sandra, Medland, Sarah, Faraone, Stephen V., Reichborn-Kjennerud, Ted, Banaschewski, Tobias, Hawi, Ziarih, Berretta, Sabina, Macosko, Evan Z., Sebat, Jonathan, O’Connor, Luke J., Hougaard, David M., Børglum, Anders D., Talkowski, Michael E., McCarroll, Steven A., Robinson, Elise B.

Publikováno v: Nature Genetics, 54(11), 1630-1639. Nature Publishing Group
Nature Genetics
Weiner, D J, Ling, E, Erdin, S, Tai, D J C, Yadav, R, Grove, J, Fu, J M, Nadig, A, Carey, C E, Baya, N, Bybjerg-Grauholm, J, Mortensen, P B, Werge, T, Demontis, D, Mors, O, Nordentoft, M, Als, T D, Baekvad-Hansen, M, Rosengren, A, Havdahl, A, Hedemand, A, Palotie, A, Chakravarti, A, Arking, D, Sulovari, A, Starnawska, A, Thiruvahindrapuram, B, de Leeuw, C, Carey, C, Ladd-Acosta, C, van der Merwe, C, Devlin, B, Cook, E H, Eichler, E, Corfield, E, Dieleman, G, Schellenberg, G, Hakonarson, H, Coon, H, Dziobek, I, Vorstman, J, Girault, J, Sutcliffe, J S, Duan, J, Nurnberger, J, Hallmayer, J, Buxbaum, J, Piven, J, Weiss, L, Davis, L, Janecka, M, Mattheisen, M, State, M W, Gill, M, Daly, M, Uddin, M, Andreassen, O, Szatmari, P, Lee, P H, Anney, R, Ripke, S, Satterstrom, K, Santangelo, S, Kuo, S, van Elst, L T, Rolland, T, Bougeron, T, Polderman, T, Turner, T, Underwood, J, Manikandan, V, Pillalamarri, V, Warrier, V, Philipsen, A, Reif, A, Hinney, A, Cormand, B, Bau, C H D, Rovaris, D L, Sonuga-Barke, E, Corfield, E, Grevet, E H, Salum, G, Larsson, H, Buitelaar, J, Haavik, J, McGough, J, Kuntsi, J, Elia, J, Lesch, K-P, Klein, M, Bellgrove, M, Tesli, M, Leung, P W L, Pan, P M, Dalsgaard, S, Loo, S, Medland, S, iPSYCH Consortium, Faraone, S V, ASD Working Group of the Psychiatric Genomics Consortium, Reichborn-Kjennerud, T, ADHD Working Group of the Psychiatric Genomics Consortium, Banaschewski, T, Hawi, Z, Berretta, S, Macosko, E Z, Sebat, J, O’Connor, L J, Hougaard, D M, Børglum, A D, Talkowski, M E, McCarroll, S A & Robinson, E B 2022, ' Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p ', Nature Genetics, vol. 54, no. 11, pp. 1630-1639 . https://doi.org/10.1038/s41588-022-01203-y
Weiner, D J, Ling, E, Erdin, S, Tai, D J C, Yadav, R, Grove, J, Fu, J M, Nadig, A, Carey, C, Baya, N, Bybjerg-Grauholm, J, Mortensen, P B, Werge, T, Demontis, D, Mors, O, Nordentoft, M, Als, T D, Baekvad-Hansen, M, Rosengren, A, Havdahl, A, Hedemand, A, Palotie, A, Chakravarti, A, Arking, D, Sulovari, A, Starnawska, A, Thiruvahindrapuram, B, de Leeuw, C, Carey, C, Ladd-Acosta, C, van der Merwe, C, Devlin, B, Cook, E H, Eichler, E, Corfield, E, Dieleman, G, Schellenberg, G, Hakonarson, H, Coon, H, Dziobek, I, Vorstman, J, Girault, J, Sutcliffe, J S, Duan, J, Nurnberger, J, Hallmayer, J, Buxbaum, J, Hinney, A, Larsson, H, Dalsgaard, S, iPSYCH Consortium, ASD Working Group of the Psychiatric Genomics Consortium & ADHD Working Group of the Psychiatric Genomics Consortium 2022, ' Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p ', Nature Genetics, vol. 54, pp. 1630-1639 . https://doi.org/10.1038/s41588-022-01203-y
Weiner, D J, Ling, E, Erdin, S, Tai, D J C, Yadav, R, Grove, J, Fu, J M, Nadig, A, Carey, C E, Baya, N, Bybjerg-Grauholm, J, iPSYCH Consortium, ASD Working Group of the Psychiatric Genomics Consortium, ADHD Working Group of the Psychiatric Genomics Consortium, Berretta, S, Macosko, E Z, Sebat, J, O'Connor, L J, Hougaard, D M, Børglum, A D, Talkowski, M E, McCarroll, S A & Robinson, E B 2022, ' Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p ', Nature Genetics, vol. 54, no. 11, pp. 1630-1639 . https://doi.org/10.1038/s41588-022-01203-y
iPSYCH Consortium, ASD Working Group of the Psychiatric Genomics Consortium & ADHD Working Group of the Psychiatric Genomics Consortium 2022, ' Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p ', Nature genetics, vol. 54, no. 11, pp. 1630-1639 . https://doi.org/10.1038/s41588-022-01203-y
Nature genetics, 54(11), 1630-1639. Nature Publishing Group

in press, weitere Verfasser:innen aus Einrichtungen außerhalb der Universität Duisburg-Essen sind nicht aufgeführt. The canonical paradigm for converting genetic association to mechanism involves iteratively mapping individual associations to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcf3982bc4fc5cf21c2b7660e0ef09e
https://research.vumc.nl/en/publications/4e6630bb-b283-4456-868d-7258b838f53d

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Functionally Informative Tag SNP Selection Using a Pareto-Optimal Approach.

Autor: Lee, Phil Hyoun, Jung, Jae-Yoon, Shatkay, Hagit

Publikováno v: Advances in Computational Biology; 2011, p173-180, 8p