Antiproliferative Effect of Telmisartan via PPARγ-Activation in Human Colon Cancer Cells

Autor: Lee, LD, Mafura, B, Dullat, S, Lauscher, JC, Buhr, HJ, Ritz, JP, Gröne, J

Publikováno v: 128. Kongress der Deutschen Gesellschaft für Chirurgie; 20110503-20110506; München; DOC11dgch352 /20110520/

Introduction: Telmisartan, an AT1-Receptor-Antagonist for essential hypertension therapy, also shows partial Peroxisom Proliferator Activated Receptor γ (PPARγ) activation in preadipocytes with metabolic effects. In tumor cells, PPARγ activation l

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Reversible Disulfide Bond Cross-Links as Tunable Levers of Phase Separation in Designer Biomolecular Condensates.

Autor: Mondal M; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States., Jankoski PE; School of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States., Lee LD; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States., Dinakarapandian DM; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0002, United States., Chiu TY; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0002, United States., Swetman WS; School of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States., Wu H; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0002, United States., Paravastu AK; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332-0002, United States., Clemons TD; School of Polymer Science and Engineering, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States., Rangachari V; Department of Chemistry and Biochemistry, School of Mathematics and Natural Sciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.; Center for Molecular and Cellular Biosciences, University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2024 Sep 11; Vol. 146 (36), pp. 25299-25311. Date of Electronic Publication: 2024 Aug 28.