Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Lee, Josephson"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Positron emission tomography (PET) constitutes a functional imaging technique that is harnessed to probe biological processes in vivo. PET imaging has been used to diagnose and monitor the progression of diseases, as well as to facilitate dr
Externí odkaz:
https://doaj.org/article/fd0ebc3222f8447caabbefd5963ae7f7
Autor:
Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Andre Jeyarajan, Xiaoyun Deng, Hualong Fu, Qingzhen Yu, Steve H. Rwema, Wenyu Lin, Mikhail Papisov, Lee Josephson, Raymond T. Chung, Steven H. Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 308-315 (2022)
Monoacylglycerol lipase (MAGL) is a pivotal enzyme in the endocannabinoid system, which metabolizes 2-arachidonoylglycerol (2-AG) into the proinflammatory eicosanoid precursor arachidonic acid (AA). MAGL and other endogenous cannabinoid (EC) degradin
Externí odkaz:
https://doaj.org/article/8eeb1fa8620445a3995e56ae5f3595fe
Autor:
Zhen Chen, Wakana Mori, Jian Rong, Michael A. Schafroth, Tuo Shao, Richard S. Van, Daisuke Ogasawara, Tomoteru Yamasaki, Atsuto Hiraishi, Akiko Hatori, Jiahui Chen, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Jiyun Sun, Qingzhen Yu, Thomas L. Collier, Yihan Shao, Benjamin F. Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1686-1695 (2021)
As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been
Externí odkaz:
https://doaj.org/article/6647b3af1e7f460aab63220f173d99be
Autor:
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Weijian Ye, Lee Josephson, Jeffrey H. Meyer, Ming-Rong Zhang, Neil Vasdev, Jinghao Wang, Hao Xu, Lu Wang, Steven H. Liang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 373-393 (2021)
The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in steroidogenic cells. Brain TSPO expression is relatively low under physiological con
Externí odkaz:
https://doaj.org/article/f41bf533ef0c495f89c741de8840c7ea
Autor:
Zhen Chen, Jiahui Chen, Laigao Chen, Chi-Hyeon Yoo, Jian Rong, Hualong Fu, Tuo Shao, Karen Coffman, Stefanus J. Steyn, April T. Davenport, James B. Daunais, Ahmed Haider, Lee Collier, Lee Josephson, Hsiao-Ying Wey, Lei Zhang, Steven H. Liang
Publikováno v:
Journal of Medicinal Chemistry. 66:1712-1724
Publikováno v:
Molecular Imaging, Vol 18 (2019)
Nonalcoholic fatty liver disease (NAFLD) is a significant public health challenge afflicting approximately 1 billion individuals both in the Western world and in the East world. While liver biopsy is considered as gold standard in the diagnosis and s
Externí odkaz:
https://doaj.org/article/5e9b9d0a30484187b14ccf4ed22aa79c
Autor:
Howard H. Chen, Zehedina Khatun, Lan Wei, Choukri Mekkaoui, Dakshesh Patel, Sally Ji Who Kim, Asma Boukhalfa, Efosa Enoma, Lin Meng, Yinching I. Chen, Leena Kaikkonen, Guoping Li, Diane E. Capen, Parul Sahu, Anand T. N. Kumar, Robert M. Blanton, Hushan Yuan, Saumya Das, Lee Josephson, David E. Sosnovik
Publikováno v:
Nature Biomedical Engineering. 6:1045-1056
Autophagy-the lysosomal degradation of cytoplasmic components via their sequestration into double-membraned autophagosomes-has not been detected non-invasively. Here we show that the flux of autophagosomes can be measured via magnetic resonance imagi
Autor:
Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Richard S. Van, Tuo Shao, Zhen Chen, Xiaofei Zhang, Erick R. Calderon Leon, Yiding Zhang, Wakana Mori, Katsushi Kumata, Tomoteru Yamasaki, Lin Xie, Shaofa Sun, Lu Wang, Chongzhao Ran, Yihan Shao, Benjamin Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H. Liang
Publikováno v:
Acta Pharmacologica Sinica. 43:3002-3010
Autor:
Lee Josephson PhD, Nancy Stratman MS, YuTing Liu MS, Fang Qian MS, Steven H. Liang PhD, Neil Vasdev PhD, Shil Patel PhD
Publikováno v:
Molecular Imaging, Vol 17 (2018)
Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. BF-227 has been described as an α-Syn binder and hence was
Externí odkaz:
https://doaj.org/article/fcc99597a79242698251f810a781528a
Autor:
Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD
Publikováno v:
Molecular Imaging, Vol 17 (2018)
The dynamic and multicellular processes of neuroinflammation are mediated by the nonneuronal cells of the central nervous system, which include astrocytes and the brain’s resident macrophages, microglia. Although initiation of an inflammatory respo
Externí odkaz:
https://doaj.org/article/eafe70a009ad4220b022e707f7b205ae