Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leduo Zhang"'
Autor:
Yuan Hong, Xia Guangxin, AnDi Li, Zhe Wang, Ge Hui, Mao Yu, Shi Chen, Weijun Shi, Wang Qian, Na Chen, Liao Xuemei, Liu Yanjun, Xin Li, Li Wang, Leduo Zhang
Publikováno v:
Cancer Science
The cyclin‐dependent kinase (CDK)4/6‐cyclin D1‐Rb‐p16/ink4a pathway is responsible for regulating cell progression past the G1 restriction point during the cell cycle. The development of a majority of human tumors is associated with dysregula
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 45:15-26
SPH3127 is a novel direct renin inhibitor designed as an oral drug for the regulation of blood pressure and body fluid homeostasis via the renin–angiotensin–aldosterone system (RAAS). This candidate is now being evaluated in a phase I clinical tr
Autor:
Jianxin Yu, Shi Chen, Huo Guoyong, Na Chen, Li Wang, Xia Guangxin, Liao Xuemei, Liu Yanjun, Zhai Xiong, Xiao Wenbo, Weijun Shi, Mao Yu, Leduo Zhang, Wang Qian, Zhe Wang, Han Yanan, Ge Hui, Yuan Hong
Publikováno v:
European Journal of Medicinal Chemistry. 178:352-364
Targeting CDK4/6 has been identified as an effective therapeutics for treatment of cancer. We herein reported the discovery of a series of 6-(2-(methylamino)ethyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-amine derivatives as CDK4/6 inhibitors against c
Autor:
Ge Hui, Leduo Zhang, Jianxin Yu, Shi Chen, Na Chen, Wang Qian, Weijun Shi, Huo Guoyong, Mao Yu, Zhe Wang, Li Wang, Liao Xuemei, Xia Guangxin, Zhai Xiong, Ke Ying, Yuan Hong
Publikováno v:
European journal of medicinal chemistry. 193
CDK4/6 has been identified as an attractive therapeutic target for treatment of cancer. For unmet clinical needs, a novel class of imidazo [1',2':1,6]pyrido [2,3-d]pyrimidin derivatives, which had distinctive triheteroaryl structure, had been discove
Autor:
Xia Guangxin, Wang Yuji, Li Gongxing, Li-Jun Hao, Yu Hao, Shi Chen, Jing Zhang, Jianxin Yu, C. Zhang, Leduo Zhang, Fan Yi, Mao Yu, Bai Rui, Na Chen, Zhao Fei, Liu Yanjun
Publikováno v:
European Journal of Medicinal Chemistry. 134:147-158
c-Met/HGF signaling pathway plays an important role in cancer progression, and it was considered to be related to poor prognosis and drug resistance. Based on metabolite profiling of (S)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]py
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 109
SPH3127, a newly developed oral nonpeptide direct renin inhibitor with good tolerance and favorable ADME (absorption distribution metabolism excretion) properties in preclinical species, is now being evaluated in phase Ι clinical trial. In this work
Publikováno v:
Clinical Therapeutics. 43:735.e1-735.e14
Purpose To evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of single- and multiple-dose SPH3127 in healthy individuals. Methods This was a randomized, double-blind, placebo-controlled, Phase I dose-escalation study. Findings
Publikováno v:
Proceedings of the 8th International Conference on Management and Computer Science (ICMCS 2018).
Autor:
Xia Guangxin, Chen Ma, Wenteng Chen, Ping Li, Xing Sun, Hailin Deng, Xu Jia, Xiang Zhixiong, Bojun Li, Leduo Zhang, Jing Zhang, Liu Yanjun, Jiaan Shao, Weixing Qi, Hong Miao, Yongping Yu, Li Yufeng, Han Jiansheng, Wei Huang, Jingkang Shen, Zhang Yong
Publikováno v:
Journal of Medicinal Chemistry. 57:9889-9900
Gatekeeper T790 M mutation in EGFR is the most prevalent factor underlying acquired resistance. Acrylamide-bearing quinazoline derivatives are powerful irreversible inhibitors for overcoming resistance. Nevertheless, concerns about the risk of nonspe
Publikováno v:
Bioorganicmedicinal chemistry. 25(10)