Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ledong Wan"'
Autor:
Yimin Zhu, Hanlin Lu, Dandan Zhang, Meiyan Li, Xiaohui Sun, Ledong Wan, Dan Yu, Yiping Tian, Hongchuan Jin, Aifen Lin, Fei Gao, Maode Lai
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic reprogramming. Disequi
Externí odkaz:
https://doaj.org/article/32b1723f1fc949e08d4afb913197285c
Autor:
Ledong Wan, Kuang-Ting Lin, Mohammad Alinoor. Rahman, Yuma Ishigami, Zhikai Wang, Mads A. Jensen, John E. Wilkinson, Youngkyu Park, David A. Tuveson, Adrian R. Krainer
Publikováno v:
Cancer Discovery.
Inflammation is strongly associated with pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy. Dysregulated RNA splicing factors have been widely reported in tumorigenesis, but their involvement in pancreatitis and PDAC is not well und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9324af3271ede6831a6a8d2121551b1
https://doi.org/10.1158/2159-8290.cd-22-1013
https://doi.org/10.1158/2159-8290.cd-22-1013
Publikováno v:
bioRxiv
Aberrant alternative splicing is emerging as a cancer hallmark and a potential therapeutic target. It is the result of dysregulated splicing factors or genetic alterations in splicing-regulatorycis-elements. Targeting individual altered splicing even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dd14c007639df8f3370d6de82dda68
https://europepmc.org/articles/PMC10103938/
https://europepmc.org/articles/PMC10103938/
Publikováno v:
Genes. 13(9)
Substantial emerging evidence supports that dysregulated RNA metabolism is associated with tumor initiation and development. Serine/Arginine-Rich proteins (SR) are a number of ultraconserved and structurally related proteins that contain a characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c251fe1542195e49804cf8bc62a16f
https://pubmed.ncbi.nlm.nih.gov/36140826
https://pubmed.ncbi.nlm.nih.gov/36140826
Autor:
Mengqi Zhao, Aitian Chen, Pei-Yuan Huang, Chen Liu, Laichuan Shen, Jiahao Liu, Le Zhao, Bin Fang, Wen-Cheng Yue, Dongxing Zheng, Ledong Wang, Hao Bai, Ka Shen, Yan Zhou, Shasha Wang, Enlong Liu, Shikun He, Yong-Lei Wang, Xixiang Zhang, Wanjun Jiang
Publikováno v:
npj Quantum Materials, Vol 9, Iss 1, Pp 1-7 (2024)
Abstract Magnetic skyrmions are topological spin textures that are regarded as promising information carriers for next-generation spintronic memory and computing devices. For practical applications, their deterministic generation, manipulation, and e
Externí odkaz:
https://doaj.org/article/60747ac8b9934dd8a277717c444c8dbe
Autor:
Xue-Yan He, David Ng, Yuan Gao, Evdokia Michalopoulou, Shanu George, Jose M. Adrover, Lijuan Sun, Jean Albrengues, Ledong Wan, Xiao Han, Christopher Vakoc, Linda Van Aelst, Mikala Egeblad
Publikováno v:
Cancer Research. 83:62-62
There is emerging evidence that exposure to chronic stress is associated with increased risk of metastasis and poor survival in cancer patients. However, the underlying molecular and cellular mechanisms responsible for the effects of stress on tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a282134ec97158917406c0f46aca17c7
https://doi.org/10.1158/1538-7445.am2023-62
https://doi.org/10.1158/1538-7445.am2023-62
Autor:
Young-Kyu Park, Ledong Wan, Kuan-Ting Lin, Zhikai Wang, Mohammad Alinoor Rahman, Adrian R. Krainer, Mads A. Jensen, David A. Tuveson
The gene encoding KRAS GTPase is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC), triggering the formation of precursor lesions, i.e., acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). However, the maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb55b92afde1dfc28f8656d6e868d34
https://doi.org/10.1101/2021.10.13.464210
https://doi.org/10.1101/2021.10.13.464210
Autor:
Young-Kyu Park, Mohammad Alinoor Rahman, Kuan-Ting Lin, Adrian R. Krainer, David A. Tuveson, Ledong Wan, Zhikai Wang
Publikováno v:
Cancer Research. 81:PR-011
KRAS is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC), triggering the formation of acinar-to-ductal metaplasia (ADM) and pancreatic intraepithelial neoplasia (PanIN). However, the majority of pancreatic cells from KC (LSL-KrasG12D/+;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88fde21ad7287e1a46991a5b2c43ce5
https://doi.org/10.1158/1538-7445.panca21-pr-011
https://doi.org/10.1158/1538-7445.panca21-pr-011
Publikováno v:
Journal of Cellular and Molecular Medicine
Recent studies have revealed many different long noncoding RNAs (lncRNA), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun. Here, we found that expression of HOTAIRM1 was reduced in colorectal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c93fa18bb60794f643bfa9bace9793
http://europepmc.org/articles/PMC5082402
http://europepmc.org/articles/PMC5082402
Autor:
Hanlin Lu, Dandan Zhang, Aifen Lin, Xiaohui Sun, Maode Lai, Yimin Zhu, Meiyan Li, Fei Gao, Ledong Wan, Dan Yu, Yiping Tian, Hongchuan Jin
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Clinical Epigenetics
Clinical Epigenetics
Background DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic reprogramming. Disequilibrium i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29af644814ad38982e278112216b1b2a
https://doi.org/10.1186/s13148-018-0458-3
https://doi.org/10.1186/s13148-018-0458-3