Zobrazeno 1 - 10
of 14 818
pro vyhledávání: '"Leder A."'
Resistance to therapy remains a significant challenge in cancer treatment, often due to the presence of a stem-like cell population that drives tumor recurrence post-treatment. Moreover, many anticancer drugs inadvertently induce plasticity, revertin
Externí odkaz:
http://arxiv.org/abs/2409.18879
Autor:
HAYSTAC Collaboration, Bai, Xiran, Jewell, M. J., Echevers, J., van Bibber, K., Droster, A., Esmat, Maryam H., Ghosh, Sumita, Graham, Eleanor, Jackson, H., Laffan, Claire, Lamoreaux, S. K., Leder, A. F., Lehnert, K. W., Lewis, S. M., Maruyama, R. H., Nath, R. D., Rapidis, N. M., Ruddy, E. P., Silva-Feaver, M., Simanovskaia, M., Singh, Sukhman, Speller, D. H., Zacarias, Sabrina, Zhu, Yuqi
This Letter reports new results from the HAYSTAC experiment's search for dark matter axions in our galactic halo. It represents the widest search to date that utilizes squeezing to realize sub-quantum limited noise. The new results cover 1.71 $\mu$eV
Externí odkaz:
http://arxiv.org/abs/2409.08998
Autor:
Lewis, Samantha M., Goulart, Dillon T., Barbosa, Mirelys Carcana, Leder, Alexander F., Sindhwad, Aarav M., Urdinaran, Isabella, van Bibber, Karl
Axions are a well-motivated dark matter candidate particle. Haloscopes aim to detect axions in the galactic halo by measuring the photon signal resulting from axions interacting with a strong magnetic field. Existing haloscopes are primarily targetin
Externí odkaz:
http://arxiv.org/abs/2408.03861
In this paper, we introduce a new optimization algorithm that is well suited for solving parameter estimation problems. We call our new method cubic regularized Newton with affine scaling (CRNAS). In contrast to so-called first-order methods which re
Externí odkaz:
http://arxiv.org/abs/2407.04235
Autor:
Myklebust, Even Moa, Frigessi, Arnoldo, Schjesvold, Fredrik, Foo, Jasmine, Leder, Kevin, Köhn-Luque, Alvaro
Predicting cancer dynamics under treatment is challenging due to high inter-patient heterogeneity, lack of predictive biomarkers, and sparse and noisy longitudinal data. Mathematical models can summarize cancer dynamics by a few interpretable paramet
Externí odkaz:
http://arxiv.org/abs/2405.14508
In this study, we develop consistent estimators for key parameters that govern the dynamics of tumor cell populations when subjected to pharmacological treatments. While these treatments often lead to an initial reduction in the abundance of drug-sen
Externí odkaz:
http://arxiv.org/abs/2403.13081
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Some theories in economics and psychology propose that background uncertainty, which is uncertainty that is independent of a person’s actual decision, can alter people’s risk-taking behavior with respect to that decision. However, previo
Externí odkaz:
https://doaj.org/article/be45a5f2f23b4fad8bf55377efed4353
The site frequency spectrum (SFS) is a widely used summary statistic of genomic data. Motivated by recent evidence for the role of neutral evolution in cancer, we investigate the SFS of neutral mutations in an exponentially growing population. Using
Externí odkaz:
http://arxiv.org/abs/2307.03346
Publikováno v:
Journal of Theoretical Biology, 568 (2023), 111497
Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer evolution. In many cancers, these mechanisms have been observed to induce dynamic switching between two or more cell states, which commonl
Externí odkaz:
http://arxiv.org/abs/2306.08096
Autor:
Kupferman, Raz, Leder, Roee
We solve a problem posed by Calabi more than 60 years ago, known as the Saint-Venant compatibility problem: Given a compact Riemannian manifold, generally with boundary, find a compatibility operator for Lie derivatives of the metric tensor. This pro
Externí odkaz:
http://arxiv.org/abs/2304.08977