Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Ledeboer MW"'
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3
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4
Akademický článek
Transplanted organoids empower human preclinical assessment of drug candidate for the clinic.
Autor: Westerling-Bui AD; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Fast EM; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Soare TW; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Venkatachalan S; Goldfinch Bio Inc., Cambridge, MA 02142, USA., DeRan M; Diamond Age Data Science, Somerville, MA 02143, USA., Fanelli AB; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Kyrychenko S; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Hoang H; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Corriea GM; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Zhang W; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Yu M; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Daniels M; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Malojcic G; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Pan-Zhou XR; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Ledeboer MW; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Harmange JC; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Emani M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tibbitts TT; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Reilly JF; Goldfinch Bio Inc., Cambridge, MA 02142, USA., Mundel P; Goldfinch Bio Inc., Cambridge, MA 02142, USA.
Publikováno v: Science advances [Sci Adv] 2022 Jul 08; Vol. 8 (27), pp. eabj5633. Date of Electronic Publication: 2022 Jul 06.
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5
Akademický článek
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Autor: Vinayagam D; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Quentin D; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Yu-Strzelczyk J; Department of Neurophysiology, Physiological Institute, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Sitsel O; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Merino F; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Stabrin M; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Hofnagel O; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany., Yu M; Goldfinch Bio, Cambridge, United States., Ledeboer MW; Goldfinch Bio, Cambridge, United States., Nagel G; Department of Neurophysiology, Physiological Institute, Julius-Maximilians-Universität Würzburg, Würzburg, Germany., Malojcic G; Goldfinch Bio, Cambridge, United States., Raunser S; Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, Dortmund, Germany.
Publikováno v: ELife [Elife] 2020 Nov 25; Vol. 9. Date of Electronic Publication: 2020 Nov 25.
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6
Akademický článek
Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.
Autor: Yu M; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Ledeboer MW; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Daniels M; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Malojcic G; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Tibbitts TT; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Coeffet-Le Gal M; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Pan-Zhou XR; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Westerling-Bui A; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Beconi M; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Reilly JF; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Mundel P; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States., Harmange JC; Drug Discovery, and Biology, Goldfinch Bio Inc., Cambridge, Massachusetts 02142, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Oct 22; Vol. 10 (11), pp. 1579-1585. Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).
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7
Akademický článek
Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2.
Autor: Farmer LJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Clark MP; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Boyd MJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Perola E; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jones SM; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Tsai A; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jacobs MD; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bandarage UK; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ledeboer MW; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Wang T; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Deng H; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ledford B; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Gu W; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Duffy JP; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bethiel RS; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Shannon D; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Byrn RA; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Leeman JR; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Rijnbrand R; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennett HB; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., O'Brien C; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Memmott C; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Nti-Addae K; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennani YL; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Charifson PS; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Jan 20; Vol. 8 (2), pp. 256-260. Date of Electronic Publication: 2017 Jan 20 (Print Publication: 2017).
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8
Akademický článek
Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
Autor: Bandarage UK; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Clark MP; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Perola E; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Gao H; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jacobs MD; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Tsai A; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Gillespie J; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Kennedy JM; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Maltais F; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ledeboer MW; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Davies I; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Gu W; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Byrn RA; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Nti Addae K; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennett H; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Leeman JR; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jones SM; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., O'Brien C; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Memmott C; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennani Y; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Charifson PS; Vertex Pharmaceuticals Incorporated , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Jan 18; Vol. 8 (2), pp. 261-265. Date of Electronic Publication: 2017 Jan 18 (Print Publication: 2017).
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9
Akademický článek
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.
Autor: Farmer LJ; Vertex Pharmaceuticals (Canada) Inc. , 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada., Ledeboer MW; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Hoock T; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Arnost MJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bethiel RS; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bennani YL; Vertex Pharmaceuticals (Canada) Inc. , 275 Armand-Frappier, Laval, Québec H7V 4A7, Canada., Black JJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Brummel CL; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Chakilam A; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Dorsch WA; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Fan B; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Cochran JE; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Halas S; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Harrington EM; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Hogan JK; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Howe D; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Huang H; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Jacobs DH; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Laitinen LM; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Liao S; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Mahajan S; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Marone V; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Martinez-Botella G; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., McCarthy P; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Messersmith D; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Namchuk M; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Oh L; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Penney MS; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Pierce AC; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Raybuck SA; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Rugg A; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Salituro FG; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Saxena K; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Shannon D; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Shlyakter D; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Swenson L; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Tian SK; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Town C; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Wang J; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Wang T; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Wannamaker MW; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Winquist RJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States., Zuccola HJ; Vertex Pharmaceuticals Inc. , 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Sep 24; Vol. 58 (18), pp. 7195-216. Date of Electronic Publication: 2015 Sep 10.
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10
Akademický článek
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
Autor: Collier PN; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Messersmith D; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Le Tiran A; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Bandarage UK; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Boucher C; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Come J; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Cottrell KM; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Damagnez V; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Doran JD; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Griffith JP; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Khare-Pandit S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Krueger EB; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ledeboer MW; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Ledford B; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Liao Y; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Mahajan S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Moody CS; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Roday S; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Wang T; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Xu J; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States., Aronov AM; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jul 23; Vol. 58 (14), pp. 5684-8. Date of Electronic Publication: 2015 Jul 06.
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