Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Leda Roche"'
Autor:
Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J. O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H. McKerrow, Charles S. Craik, Conor R. Caffrey, José F. Tort
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue mi
Externí odkaz:
https://doaj.org/article/d4c2423d90c340b9bc971306ed846e6a
Autor:
Ileana Corvo, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Alegra Eroy-Reveles, Leda Roche, James H McKerrow, John P Dalton, Charles S Craik, Conor R Caffrey, José F Tort
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 7, p e2269 (2013)
A family of secreted cathepsin L proteases with differential activities is essential for host colonization and survival in the parasitic flatworm Fasciola hepatica. While the blood feeding adult secretes predominantly FheCL1, an enzyme with a strong
Externí odkaz:
https://doaj.org/article/39e3cf915bba40f283c68f81e3d26e2e
Autor:
Mark W Robinson, Ileana Corvo, Peter M Jones, Anthony M George, Matthew P Padula, Joyce To, Martin Cancela, Gabriel Rinaldi, Jose F Tort, Leda Roche, John P Dalton
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 4, p e1012 (2011)
BACKGROUND: The temporal expression and secretion of distinct members of a family of virulence-associated cathepsin L cysteine peptidases (FhCL) correlates with the entry and migration of the helminth pathogen Fasciola hepatica in the host. Thus, inf
Externí odkaz:
https://doaj.org/article/0d9f9991408b4538968d958192283b3b
Autor:
Víctor Raggio, Leda Roche
Publikováno v:
Revista Médica del Uruguay, Vol 25, Iss 1 (2009)
En los últimos diez años se ha visto un aumento exponencial tanto de los conocimientos en genética médica como en la capacidad de analizar el genoma humano. En los próximos años es probable que estas tendencias continúen, haciendo necesaria la
Externí odkaz:
https://doaj.org/article/088a9e899e404647912c3d57c7e7065a
Publikováno v:
Revista Médica del Uruguay, Vol 23, Iss 2 (2007)
Las nuevas modalidades académicas de educación continua flexible o a distancia, o ambas, que fortalecen la capacidad de autoaprendizaje y el uso de las nuevas tecnologías de la información y comunicación, compensan en parte las condiciones adver
Externí odkaz:
https://doaj.org/article/3a976efd905a4055b3358bc12a50ae65
Autor:
Alvaro Díaz, Martín Cancela, Arnaldo Zaha, Edileuza Danieli da Silva, Henrique Bunselmeyer Ferreira, Ileana Corvo, Leda Roche, Aline Teichmann, José Fransisco Tort
Publikováno v:
Parasitology. 144:1695-1707
SUMMARYCystatins are small, phylogenetically conserved proteins that are tight-binding inhibitors of cysteine proteinases. The liver flukeFasciola hepaticauses a diverse set of cysteine proteinases of the papain superfamily for host invasion, immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d833c6fddfe1d769aa91517d9e80265
https://doi.org/10.1017/s0031182017001093
https://doi.org/10.1017/s0031182017001093
Autor:
Natalia Pi-Denis, Lucía Pastro, Gabriel Peluffo, Nicolás Curbelo, Alejandra Vomero, Leda Roche, María Boidi, Víctor Raggio, Martin Ciganda, Alejandra Tapié, Jorge Souto
Publikováno v:
COLIBRI
Universidad de la República
instacron:Universidad de la República
Clinical Case Reports
Universidad de la República
instacron:Universidad de la República
Clinical Case Reports
Key Clinical Message Mutations in ARX gene should be considered in patients with mental disability or/and epilepsy. It is an X‐linked gene that has pleiotropic effects. Here, we report the case of a boy diagnosed with Ohtahara syndrome. We performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc103ecb6c53bff4b71e56c98c86f11
https://doi.org/10.1002/ccr3.769
https://doi.org/10.1002/ccr3.769
Autor:
Conor R. Caffrey, Alicia Merlino, José F. Tort, Leda Roche, Lucía Pastro, James H. McKerrow, Ileana Corvo, Kathrin Zuberbühler, Tatiana Basika, Anthony J. O’Donoghue, Charles S. Craik, Florencia Ferraro, Natalia Pi-Denis
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 5 (2018)
Frontiers in Molecular Biosciences, Vol 5 (2018)
Cysteine proteases are widespread in all life kingdoms, being central to diverse physiological processes based on a broad range of substrate specificity. Paralogous Fasciola hepatica cathepsin L proteases are essential to parasite invasion, tissue mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819b246a53aead9a5b748f9b02846ca0
http://europepmc.org/articles/PMC5917446
http://europepmc.org/articles/PMC5917446
Autor:
Gabriela Maggioli, Daniel Acosta, Tatiana Basika, Diego Rosadilla, José F. Tort, Valeria Gayo, Fernando Silveira, Leda Roche, Silvina Rossi, Sheila Giacaman, Carlos Carmona
Publikováno v:
Vaccine. 29:9057-9063
Fasciola hepatica M17 leucine aminopeptidase (FhLAP) is thought to play a role in catabolizing peptides generated by the concerted activity of gut-associated endopeptidases on host polypeptides, thus releasing amino acids to be used in protein anabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6beb29393889cb192cfc156c4c916801
https://doi.org/10.1016/j.vaccine.2011.09.020
https://doi.org/10.1016/j.vaccine.2011.09.020
Publikováno v:
Molecular and Biochemical Parasitology. 167:41-47
Secreted cysteine proteases are major players in host-parasite interactions; in Fasciola hepatica, a distinct group of cathepsins L was found to be predominantly expressed in the juvenile stages, but their enzymatic properties were unknown. Cathepsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17702ba87b6c4d46a467d41c3f2a5784
https://doi.org/10.1016/j.molbiopara.2009.04.005
https://doi.org/10.1016/j.molbiopara.2009.04.005