Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

Autor: Liesl Wandrag, Mario Siervo, Heather L. Riley, Maryam Khosravi, Bernadette O. Fernandez, Carl A. Leckstrom, Daniel S. Martin, Kay Mitchell, Denny Z.H. Levett, Hugh E. Montgomery, Monty G. Mythen, Michael A. Stroud, Michael P.W. Grocott, Martin Feelisch

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 60-68 (2017)

Objectives: Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflam

Externí odkaz: https://doaj.org/article/16dbe4da3b5d4bd58a73af9f4a9f58bd

Central melanocortin receptor agonist reduces hepatic lipogenic gene expression in streptozotocin-induced diabetic mice

Autor: Leckstrom, Arnold, Lew, Pei San, Poritsanos, Nicole J., Mizuno, Tooru M.

Publikováno v: In Life Sciences 2011 88(15):664-669

Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

Autor: Bernadette O. Fernandez, Maryam Khosravi, Michael P.W. Grocott, Liesl Wandrag, Denny Z. H. Levett, Heather L. Riley, Michael A. Stroud, Mario Siervo, Monty G. Mythen, Daniel Martin, Martin Feelisch, Hugh Montgomery, Carl A. Leckstrom, Kay Mitchell

Publikováno v: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 60-68 (2017)

Objectives Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13f9a6e4ecdd77935aa535463984bb2
https://eprints.soton.ac.uk/410618/

Pathophysiology and clinical studies in CKD 1-5

Autor: A. Gerakis, A. Halapas, M. Chrissoheris, I. Giatras, R. Andritsou, I. Nikolaou, N. Bouboulis, E. Pattakos, K. Spargias, R. Kalaitzidis, D. Karasavvidou, K. Pappas, G. Katatsis, A. Tatsioni, K. Siamopoulos, M. H. de Borst, R. Hajhosseiny, H. Tamez, J. Wenger, R. Thadhani, D. J. Goldsmith, L. Zanoli, S. Rastelli, C. Marcantoni, J. Blanco, C. Tamburino, P. Castellino, T. Larsen, J. Jensen, J. Bech, E. Pedersen, F. Mose, D. Leckstrom, T. Bhuvanakrishna, A. McGrath, D. Goldsmith, K. Muras, A. Masajtis-Zagajewska, M. Nowicki, H. C. Rayner, J. Baharani, S. Smith, V. Suresh, I. Dasgupta, F. Zarzoulas, O. Balafa, L. Di Lullo, F. Floccari, R. Rivera, A. Gorini, M. Malaguti, V. Barbera, A. Granata, A. Santoboni, M. Luczak, D. Formanowicz, E. Pawliczak, M. Wanic-Kossowska, L. Koziol, M. Figlerowicz, J. Bommer, M. Fliser, P. Roth, D. Saure, S. Vettoretti, C. Alfieri, R. Floreani, A. Regalia, C. Bonanomi, R. Meazza, F. Magrini, P. Messa, V. Jankowski, W. Zidek, J. Joachim, K. Lee, I. H. Hwang, S. B. Lee, D. W. Lee, I. Y. Kim, I. S. Kwak, E. Y. Seong, M. J. Shin, H. Rhee, B. Y. Yang, P. Dattolo, S. Michelassi, S. Sisca, M. Allinovi, M. Amidone, A. Mehmetaj, F. Pizzarelli, V. Filiopoulos, N. Manolios, D. Hadjiyannakos, D. Arvanitis, K. Panagiotopoulos, D. Vlassopoulos, J. S. Kim, B. G. Han, S. O. Choi, J. W. Yang, S. Shojai, A. Babu, P. Boddana, D. Dipankar, R. Alvarado, G. Garcia-Pino, E. Ruiz-Donoso, E. Chavez, E. Luna, F. Caravaca, H. Geiger, S. Buttner, L.-L. Lv, Y. Cao, M. Zheng, B.-C. Liu, G. N. Kouvelos, V. D. Raikou, E. M. Arnaoutoglou, H. J. Milionis, J. N. Boletis, M. I. Matsagkas, I. Raiola, F. Trepiccione, M. Pluvio, R. Raiola, G. Capasso, I. Kaykov, L. Kukoleva, R. Zverkov, A. Smirnov, S. Hammami, A. Frih, S. Hajem, M. Hammami, L. Wan

Publikováno v: Nephrology Dialysis Transplantation. 28:i366-i373

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a704b75a98e01813390e00da1222bc2d
https://doi.org/10.1093/ndt/gft133

Negative regulation of hepatic fat mass and obesity associated (Fto) gene expression by insulin

Autor: Arnold Leckstrom, Pei San Lew, Tooru M. Mizuno, Yanming Luo

Publikováno v: Life sciences. 170

Aims To investigate the role of glucose and insulin in the regulation of hepatic fat mass and obesity associated ( Fto ) gene expression and the role of hepatic Fto in the regulation of gluconeogenic gene expression. Main methods To determine the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25638fa70715f6effc07466440e5348
https://pubmed.ncbi.nlm.nih.gov/27914922