Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lechu Yu"'
Autor:
Wenya Weng, Tingwen Ge, Yi Wang, Lulu He, Tinghao Liu, Wanning Wang, Zongyu Zheng, Lechu Yu, Chi Zhang, Xuemian Lu
Publikováno v:
Diabetes & Metabolism Journal, Vol 44, Iss 4, Pp 566-580 (2020)
BackgroundFibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (O
Externí odkaz:
https://doaj.org/article/c4a1356292b248dca8ee2cb5ab89035d
Publikováno v:
Diabetes & Metabolism Journal, Vol 44, Iss 1, Pp 158-172 (2020)
BackgroundEpithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the sup
Externí odkaz:
https://doaj.org/article/01b0e06cd9114707b9dbc20a16b70712
Publikováno v:
Journal of Diabetes Research, Vol 2021 (2021)
Zinc is an essential trace element that is often reduced under the type 1 diabetic condition. Previous studies demonstrated that zinc deficiency enhanced type 1 diabetes-induced liver injury and that zinc supplementation significantly helped to preve
Externí odkaz:
https://doaj.org/article/232ab4adf2f04476acc90ef4e5b23ee7
Autor:
Liangmiao Chen, Hong Yang, Enling Ye, Zhenzhen Lin, Mengmeng Peng, Hai Lin, Lechu Yu, Zhuhua Cai, Xuemian Lu
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Objective: Adverse maternal outcomes and perinatal complications are associated with overt and subclinical maternal hypothyroidism. It is not clear whether these complications also occur in women with isolated hypothyroxinemia during pregnancy. The a
Externí odkaz:
https://doaj.org/article/f432edc56f96423eaa0fa79011e3f060
Autor:
Peng Cheng, Fangfang Zhang, Lechu Yu, Xiufei Lin, Luqing He, Xiaokun Li, Xuemian Lu, Xiaoqing Yan, Yi Tan, Chi Zhang
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Cardiovascular disease (CVD) is one of the most severe diseases in clinics. Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications. The heart is a key target as
Externí odkaz:
https://doaj.org/article/eaf169dce07945c0a5f80f16e311e63c
Autor:
Hong Yang, Minglong Shao, Liangmiao Chen, Qingshou Chen, Lechu Yu, Lingqiao Cai, Zhenzhen Lin, Chi Zhang, Xuemian Lu
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99611 (2014)
Thyroid dysfunction during pregnancy is associated with multiple adverse outcomes, but whether all women should be screened for thyroid disorders during pregnancy remains controversial.To evaluate the effectiveness of the targeted high risk case-find
Externí odkaz:
https://doaj.org/article/95db7e84cfcc4217a0484981bae40d43
Autor:
Chi Zhang, Minglong Shao, Hong Yang, Liangmiao Chen, Lechu Yu, Weitao Cong, Haishan Tian, Fangfang Zhang, Peng Cheng, Litai Jin, Yi Tan, Xiaokun Li, Lu Cai, Xuemian Lu
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82275 (2013)
BACKGROUND: Lipotoxicity is a key feature of the pathogenesis of diabetic kidney disease, and is attributed to excessive lipid accumulation (hyperlipidemia). Increasing evidence suggests that fibroblast growth factor (FGF)21 has a crucial role in lip
Externí odkaz:
https://doaj.org/article/0b1a6f773f0d42ccb69e77156b473684
Autor:
Liangmiao Chen, Enling Ye, Mengli Sun, Hai Lin, Lechu Yu, Zhenzhen Lin, Mengmeng Peng, Dini Lin, Xuemian Lu
Publikováno v:
Endocrine Journal.
Autor:
Yi Wang, Zongyu Zheng, Chi Zhang, Tinghao Liu, Lechu Yu, Lulu He, Wenya Weng, Wanning Wang, Xuemian Lu, Tingwen Ge
Publikováno v:
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal, Vol 44, Iss 4, Pp 566-580 (2020)
Diabetes & Metabolism Journal, Vol 44, Iss 4, Pp 566-580 (2020)
Background Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (
Autor:
Shiyue Sun, Xiaozhen Dai, Sun Da, Hui Chen, Junhong He, Xiangjuan Chen, Yue Su, Chi Zhang, Xiaohong Pan, Xiao Ling, Qiaoxia Dai, Haiqi Hu, Guigui Zhang, Chunjie Gu, Yi Tan, Lechu Yu, Kai Wang, Xue Meng, Xia Fan, Xiaoqing Yan
Publikováno v:
Journal of Cellular and Molecular Medicine
Diabetic vascular complications are closely associated with long‐term vascular dysfunction and poor neovascularization. Endothelial progenitor cells (EPCs) play pivotal roles in maintaining vascular homeostasis and triggering angiogenesis, and EPC