Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

Autor: Di Maggio, Francesco, Arumugam, Prabhu, Delvecchio, Francesca R., Batista, Silvia, Lechertier, Tanguy, Hodivala-Dilke, Kairbaan, Kocher, Hemant M.

Publikováno v: In Pancreatology November-December 2016 16(6):995-1004

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Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice

Autor: Alexopoulou, Annika N, Lees, Delphine M, Bodrug, Natalia, Lechertier, Tanguy, Fernandez, Isabelle, D'Amico, Gabriela, Dukinfield, Matthew, Batista, Silvia, Tavora, Bernardo, Serrels, Bryan, Hodivala-Dilke, Kairbaan

Publikováno v: Alexopoulou, A N, Lees, D M, Bodrug, N, Lechertier, T, Fernandez, I, D'Amico, G, Dukinfield, M, Batista, S, Tavora, B, Serrels, B & Hodivala-Dilke, K 2017, ' Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice ', The Journal of Pathology . https://doi.org/10.1002/path.4911

Focal adhesion kinase (FAK) inhibitors have been developed as potential anti-cancer agents and are in clinical trials. In vitro activation of FAK kinase domain triggers autophosphorylation of tyrosine 397 (Y397), Src activation and subsequent phospho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::a9828152d4da3e2f16f6f0b0b15f0ea1
https://hdl.handle.net/20.500.11820/b153a0e4-19c1-468d-9a2b-a35ab4773dd0

Dual role of pericyte alpha6beta1-integrin in tumour blood vessels

Autor: Reynolds, Louise, d'Amico, Gabriela, Lechertier, Tanguy, Papachristodoulou, Alexandros, Muñoz-Felix, José, Arcangelis, Adèle De, Baker, Marianne, Serrels, Bryan, Hodivala-Dilke, Kairbaan

Publikováno v: Journal of Cell Science
Journal of Cell Science, 2017, 130 (9), pp.1583-1595. ⟨10.1242/jcs.197848⟩

The alpha6beta1-integrin is a major laminin receptor, and formation of a laminin-rich basement membrane is a key feature in tumour blood vessel stabilisation and pericyte recruitment, processes that are important in the growth and maturation of tumou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::c36c77394677d88b5e4e9ab0556a0885
https://hal.science/hal-03691171

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