Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lech Kiedrowski"'
Autor:
Ji-in Vivien Choi, Boriana K. Tchernookova, Wasan Kumar, Lech Kiedrowski, Calla Goeke, Marina Guizzetti, John Larson, Matthew A. Kreitzer, Robert Paul Malchow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Small alterations in the level of extracellular H+ can profoundly alter neuronal activity throughout the nervous system. In this study, self-referencing H+-selective microelectrodes were used to examine extracellular H+ fluxes from individual astrocy
Externí odkaz:
https://doaj.org/article/4ed3395c6d284d03aa319593dc6ad6f2
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159582 (2016)
Increasing evidence suggests that metal dyshomeostasis plays an important role in human neurodegenerative diseases. Although distinctive metal distributions are described for mature hippocampus and cortex, much less is known about metal levels and in
Externí odkaz:
https://doaj.org/article/2bcb9c996a084b3b96f35c51a402c56c
Autor:
Alyssa M Powell, Michael Gongwer, Matthew A. Kreitzer, Boriana K. Tchernookova, Thomas Leuschner, Robert Paul Malchow, Hannah Caringal, Lech Kiedrowski, Richard L. Chappell, Anna G Phillips, Brock Goeglein, Adam W Schantz, Alexis George
Publikováno v:
Journal of Neurophysiology. 125:184-198
Glial cells are known to regulate neuronal activity, but the exact mechanism(s) whereby these “support” cells modulate synaptic transmission remains unclear. Small changes in extracellular levels of acidity are known to be particularly powerful r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aec406e3ff6580ab66196096cc4a7e4
https://doi.org/10.1152/jn.00546.2020
https://doi.org/10.1152/jn.00546.2020
Autor:
Boriana K, Tchernookova, Michael W, Gongwer, Alexis, George, Brock, Goeglein, Alyssa M, Powell, Hannah L, Caringal, Thomas, Leuschner, Anna G, Phillips, Adam W, Schantz, Lech, Kiedrowski, Richard, Chappell, Matthew A, Kreitzer, Robert Paul, Malchow
Publikováno v:
Journal of neurophysiology. 125(1)
Small alterations in extracellular H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f46f72e4e0a28dd50e120a890d5af6e4
https://pubmed.ncbi.nlm.nih.gov/33206577
https://pubmed.ncbi.nlm.nih.gov/33206577
Autor:
Alan Feinerman, Lech Kiedrowski
Publikováno v:
Journal of Neuroscience Methods. 294:111-115
Background Microscope chambers that accept glass coverslips with cultured cells are often used to monitor intracellular Ca2+ concentration ([Ca2+]i) during cell superfusion. Unfortunately, the experimental maneuvers associated with the coverslip inst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29658b2187caf2a1855715d5b9b6187
https://doi.org/10.1016/j.jneumeth.2017.11.007
https://doi.org/10.1016/j.jneumeth.2017.11.007
Autor:
Lech Kiedrowski
Publikováno v:
Journal of Neurochemistry. 135:777-786
The experiments were carried out on primary cultures of murine cortical neurons from cryopreserved preparations obtained from embryonic-day-16 fetuses. To calibrate acid-induced intracelluar [Zn(2+) ] ([Zn(2+) ]i ) elevations, a low affinity (Kd = 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a207110bf5fa398063fb5a8903807a59
https://doi.org/10.1111/jnc.13282
https://doi.org/10.1111/jnc.13282
Autor:
Lech Kiedrowski
Publikováno v:
Metals in the Brain ISBN: 9781493969166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b17733f449a3c77a260c4fada26b5e8
https://doi.org/10.1007/978-1-4939-6918-0_12
https://doi.org/10.1007/978-1-4939-6918-0_12
Autor:
Lech Kiedrowski
Publikováno v:
Journal of Neurochemistry. 130:87-96
In cultured cortical and hippocampal neurons when intracellular pH drops from 6.6 to 6.1, yet unclear intracellular stores release micromolar amounts of Zn(2+) into the cytosol. Mitochondria, acidic organelles, and/or intracellular ligands could rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8781a8d1c25b65063780cc4b3cb209b3
https://doi.org/10.1111/jnc.12712
https://doi.org/10.1111/jnc.12712
Autor:
Lech Kiedrowski
Publikováno v:
Journal of Neurochemistry. 121:438-450
In neurons exposed to glutamate, Ca²⁺ influx triggers intracellular Zn²⁺ release via an as yet unclear mechanism. As glutamate induces a Ca²⁺-dependent cytosolic acidification, the present work tested the relationships among intracellular Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::958f8b7485d371137470bd9c3c22d3c4
https://doi.org/10.1111/j.1471-4159.2012.07695.x
https://doi.org/10.1111/j.1471-4159.2012.07695.x
Autor:
Lech Kiedrowski
Publikováno v:
Journal of Neurochemistry. 117:231-243
Although Zn(2+) homeostasis in neurons is tightly regulated and its destabilization has been linked to a number of pathologies including Alzheimer's disease and ischemic neuronal death, the primary mechanisms affecting intracellular Zn(2+) concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc55168d9dc48b224a60569ef5d72c56
https://doi.org/10.1111/j.1471-4159.2011.07194.x
https://doi.org/10.1111/j.1471-4159.2011.07194.x