Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability.

Autor: Makarov M; Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague 12843, Czech Republic., Sanchez Rocha AC; Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague 12843, Czech Republic., Krystufek R; Department of Physical Chemistry, Faculty of Science, Charles University, Prague 12843, Czech Republic.; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 16610, Czech Republic., Cherepashuk I; Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague 12843, Czech Republic., Dzmitruk V; Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec 25250, Czech Republic., Charnavets T; Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV, Vestec 25250, Czech Republic., Faustino AM; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States., Lebl M; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 16610, Czech Republic., Fujishima K; Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo 1528550, Japan.; Graduate School of Media and Governance, Keio University, Fujisawa 2520882, Japan., Fried SD; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.; T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, United States., Hlouchova K; Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague 12843, Czech Republic.; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague 16610, Czech Republic.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2023 Mar 08; Vol. 145 (9), pp. 5320-5329. Date of Electronic Publication: 2023 Feb 24.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Similarity Analysis of Computer-Generated and Commercial Libraries for Targeted Biocompatible Coded Amino Acid Replacement.

Autor: Meringer, Markus¹ (AUTHOR) markus.meringer@dlr.de, Casanola-Martin, Gerardo M.² (AUTHOR) gerardo.casanolamart@ndsu.edu, Rasulev, Bakhtiyor^2,3 (AUTHOR) bakhtiyor.rasulev@ndsu.edu, Cleaves II, H. James^4,5,6 (AUTHOR) henderson.cleaves@howard.edu

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12343. 14p.

Discovery of a Novel, Potent, and Specific Family of Factor Xa Inhibitors via Combinatorial Chemistry

Autor: Wildgoose P, James A. Ostrem, D. Thorpe, Lebl M, Fahad Al-Obeidi, Spoonamore J, Cross Mt, Safarova A, Stringer Sk, Patek M, Pavel Safar, Sepetov N, Strop P, Kasireddy P, LoCascio Jc

Publikováno v: Biochemistry. 37:1053-1059

A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously described, was identified by screening a combinatorial peptide library composed of L-amino acids. The minimal inhibitory sequence is a tripeptide, L-tyrosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bc105f3357b05aef29dacca118fe77
https://doi.org/10.1021/bi971147e

A New Dipeptide H-MGL Partially Ameliorating Memory Impairment in an STZ-induced Alzheimer Model in Male Rats.

Autor: Ghasempour, Sarieh¹, Maghsoudi, Nader², Manaheji, Homa^1,3, Ghasemi, Rasoul^1,3, Jaafarisuha, Ali¹, Zaringhalam, Jalal^1,3 jzaringhalam@yahoo.com

Publikováno v: Basic & Clinical Neuroscience. Sep/Oct2024, Vol. 15 Issue 5, p583-593. 11p.