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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.

Autor: Ng VH; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA., Spencer Z; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA., Neitzel LR; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Nayak A; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Loberg MA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Shen C; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Kassel SN; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Kroh HK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., An Z; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA., Anthony CC; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Bryant JM; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Lawson A; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Goldsmith L; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Benchabane H; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA., Hansen AG; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA.; STEMCELL Technologies, 1618 Station Street, Vancouver, BC, V6A 1B6, Canada., Li J; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., D'Souza S; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA., Lebensohn AM; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Rohatgi R; Departments of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA., Weiss WA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, 94158, USA.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94158, USA., Weiss VL; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Williams C; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Hong CC; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Robbins DJ; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, 20057, USA., Ahmed Y; Department of Molecular and Systems Biology and the Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH, 03755, USA. yashi.ahmed@dartmouth.edu., Lee E; Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Program in Cancer Biology, Vanderbilt University, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. ethan.lee@vanderbilt.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Oct 05; Vol. 14 (1), pp. 6173. Date of Electronic Publication: 2023 Oct 05.

Direct ionic stress sensing and mitigation by the transcription factor NFAT5.

Autor: Khandwala CB; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Sarkar P; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Schmidt HB; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Ma M; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Kinnebrew M; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Pusapati GV; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Patel BB; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Tillo D; Center for Cancer Research Genomics Core, National Cancer Institute, National Institutes of Health, NIH, Building 37, RM 2056B, Bethesda, MD, 20892, USA., Lebensohn AM; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, NIH, Building 37, RM 2056B, Bethesda, MD, 20892, USA., Rohatgi R; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 24. Date of Electronic Publication: 2023 Sep 24.

Receptor control by membrane-tethered ubiquitin ligases in development and tissue homeostasis.

Autor: Lebensohn AM; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States. Electronic address: andres.lebensohn@nih.gov., Bazan JF; ħ bioconsulting llc, Stillwater, MN, United States. Electronic address: jfbazan@gmail.com., Rohatgi R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, United States; Department of Medicine, Stanford University School of Medicine, Stanford, CA, United States. Electronic address: rrohatgi@stanford.edu.

Publikováno v: Current topics in developmental biology [Curr Top Dev Biol] 2022; Vol. 150, pp. 25-89. Date of Electronic Publication: 2022 Jun 11.

Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens.

Autor: Patel BB; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America., Lebensohn AM; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America., Pusapati GV; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America., Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America., Salzman J; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, United States of America., Rohatgi R; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.

Publikováno v: PloS one [PLoS One] 2019 Jan 29; Vol. 14 (1), pp. e0198463. Date of Electronic Publication: 2019 Jan 29 (Print Publication: 2019).