Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Lebedev Lr"'
Autor:
Yu. V. Telegina, I. S. Shchelkunov, T. G. Tereshchenko, Lebedev Lr, V. V. Ermolaev, M. V. Alekseeva, A. Ya. Stolbov, V. P. Klimenko, Yu. S. Alikin
Publikováno v:
Innovations and Food Safety. :69-80
A proposal is being considered for the use of BAS preparations developed in the Institute of medical biotechnology OF the FBU SSC VB «Vector» in the programs of ensuring the country’s security in the field of medicine, veterinary medicine and obt
Publikováno v:
Russian Journal of Bioorganic Chemistry. 46:342-348
In order to develop a target drug we studied the process of conjugation of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and alendronic acid (ALN). The conjugation reactions were performed both in solution and in the sol
Publikováno v:
Biomeditsinskaya Khimiya. 61:652-656
A novel drug for treatment of bone metastases based on human recombinant tumor necrosis factor (TNF-alpha) has been designed. The drug is a molecular structure containing yeast double-stranded ribonucleic acid (dsRNA) covered by the conjugate of poly
Autor:
Nadezhda S. Scherbakova, Alexander A. Ilyichev, Larisa I. Karpenko, Anton N. Chikaev, Lyudmila A. Shalamova, Olga G. Pyankova, Olga Yu. Tumanova, Alexander B. Ryzhikov, Lebedev Lr
Publikováno v:
Molecular Immunology. 50:193-199
A major goal in HIV-1 vaccine research is to develop an immunogen that can elicit broadly neutralizing antibodies that efficiently neutralize a wide range of the HIV-1 subtypes. Using biopanning procedure we have selected linear peptide VGAFGSFYRLSVL
Autor:
Alexander A. Ilyichev, Bazhan Si, Lebedev Lr, Boris B. Zaitsev, Denis V. Korneev, Larisa I. Karpenko
Publikováno v:
AIDS Research and Human Retroviruses
Publikováno v:
Molecular Biology. 44:939-947
Orthopoxviral genomes bear genes for a series of homologous secreted proteins binding tumor necrosis factor (TNF). Orthopoxvirus species have different sets of these proteins. Variola virus has only one protein of this series, CrmB. Although CrmB pro
Autor:
N. I. Akulova, Yu. V. Telegina, G. M. Levagina, Ya. S. Gogina, V. F. Podgornyi, E. A. Volosnikova, V. K. Mikhailova, Lebedev Lr
Publikováno v:
Applied Biochemistry and Microbiology. 46:865-869
Optimization of the stage of fractioning of nucleotide material has been performed, and a technology for purification and obtaining of plasmid DNAs for pharmaceutical purposes has been developed. Plasmid DNAs can be used for construction of DNA vacci
Autor:
Roman V. Uzhachenko, Alexey Eroshkin, Larisa I. Karpenko, Alexander A. Ilyichev, Bazhan Si, Lebedev Lr, P. A. Belavin
Publikováno v:
Molecular Immunology. 45:661-669
Immunogenic properties of the combined vaccine CombiHIVvac, comprising polyepitope HIV-1 immunogens, one being the artificial polyepitope protein TBI, containing the T- and B-cell epitopes from Env and Gag proteins, and the DNA vaccine construct pcDN
Autor:
T. S. Nepomnyashchikh, I. A. Ryazankin, Lebedev Lr, S. G. Pozdnyakov, Sergei N. Shchelkunov, I. P. Gileva
Publikováno v:
Molecular Biology. 39:926-933
PCR was used to amplify DNA fragments containing the genes for interferon γ (IFNγ)-binding proteins (IFNγBPs) of the variola virus (VARV) and monkeypox virus (MPXV). The genes were expressed from baculovirus DNAs in Sf21 insect cells. The recombin
Autor:
Pustoshilova Nm, Lebedev Lr, I. A. Ryazankin, I. P. Gileva, T. S. Nepomnyashchikh, Totmenin Av, Z. A. Maxutov, Sergei N. Shchelkunov, Afinogenova Gn
Publikováno v:
Molecular Biology. 39:218-225
Genes for TNF-binding proteins (CrmBs) of the variola virus (VARV), monkeypox virus (MPXV) or cowpox virus (CPXV) were isolated by PCR from viral genomes and expressed in a baculovirus system in the Sf21 insect cell line. Properties of the purified r