Druggable Sterol Metabolizing Enzymes in Infectious Diseases: Cell Targets to Therapeutic Leads.

Autor: Nes WD; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA., Chaudhuri M; Department of Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN 37208, USA., Leaver DJ; School of Dentistry and Medical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.; Gulbali Institute for Agriculture, Water and Environment, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.

Publikováno v: Biomolecules [Biomolecules] 2024 Feb 20; Vol. 14 (3). Date of Electronic Publication: 2024 Feb 20.

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.

Autor: Priebbenow DL; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Leaver DJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Nguyen N; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Cleary B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Lagiakos HR; Cancer Therapeutics CRC, 343 Royal Parade, Parkville, Victoria 3052, Australia., Sanchez J; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Xue L; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China., Huang F; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China., Sun Y; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Mujumdar P; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Mudududdla R; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Varghese S; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Teguh S; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Katneni K; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Cuellar M; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States., Strasser JM; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States., Dahlin JL; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States., Walters MA; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States., Street IP; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Cancer Therapeutics CRC, 343 Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Monahan BJ; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Cancer Therapeutics CRC, 343 Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Jarman KE; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Jousset Sabroux H; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Falk H; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Cancer Therapeutics CRC, 343 Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Chung MC; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia., Hermans SJ; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia., Downer NL; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia., Voss AK; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Thomas T; Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria 3050, Australia., Baell JB; School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China.; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia.; ARC Centre for Fragment-Based Design, Monash University, Parkville, VIC 3052, Australia.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4655-4684. Date of Electronic Publication: 2020 Mar 19.

HBO1 is required for the maintenance of leukaemia stem cells.

Autor: MacPherson L; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Anokye J; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Yeung MM; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Lam EYN; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Chan YC; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Weng CF; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Yeh P; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Knezevic K; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Butler MS; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Hoegl A; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Chan KL; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Burr ML; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Gearing LJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Willson T; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Liu J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia., Choi J; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Yang Y; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Bilardi RA; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Falk H; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Melbourne, Victoria, Australia., Nguyen N; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Stupple PA; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Peat TS; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Zhang M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Melbourne, Victoria, Australia., de Silva M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Melbourne, Victoria, Australia., Carrasco-Pozo C; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia., Avery VM; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia., Khoo PS; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Children's Cancer Institute, Kensington, New South Wales, Australia., Dolezal O; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dennis ML; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Nuttall S; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Surjadi R; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Newman J; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Ren B; Cancer Therapeutics CRC, Melbourne, Victoria, Australia.; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Leaver DJ; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Sun Y; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Baell JB; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China., Dovey O; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, UK., Vassiliou GS; Wellcome-MRC Cambridge Stem Cell Institute, Department of Haematology, University of Cambridge, Cambridge, UK.; Haematological Cancer Genetics, Wellcome Sanger Institute, Cambridge, UK., Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria., Dawson SJ; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia., Street IP; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Melbourne, Victoria, Australia., Monahan BJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Melbourne, Victoria, Australia., Burns CJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Choudhary C; Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Blewitt ME; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Thomas T; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; The Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia., Dawson MA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Mark.Dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. Mark.Dawson@petermac.org.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia. Mark.Dawson@petermac.org.; Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Mark.Dawson@petermac.org.

Publikováno v: Nature [Nature] 2020 Jan; Vol. 577 (7789), pp. 266-270. Date of Electronic Publication: 2019 Dec 11.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.

Autor: Baell JB; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Jonathan.Baell@monash.edu.; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China. Jonathan.Baell@monash.edu., Leaver DJ; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Hermans SJ; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Kelly GL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Brennan MS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Downer NL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Nguyen N; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wichmann J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., McRae HM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Yang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Cleary B; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Lagiakos HR; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Mieruszynski S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Pacini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Vanyai HK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Bergamasco MI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., May RE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Davey BK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Morgan KJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sealey AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wang B; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Zamudio N; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Garnham AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sheikh BN; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Aubrey BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Doggett K; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chung MC; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., de Silva M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Bentley J; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Pilling P; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Hattarki M; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dolezal O; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dennis ML; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Falk H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Ren B; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Newbold A; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Hawkins ED; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Johnstone RW; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Peat TS; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Heath JK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia., Smyth GK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia., Street IP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Monahan BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. avoss@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. avoss@wehi.edu.au., Thomas T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. tthomas@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tthomas@wehi.edu.au.

Publikováno v: Nature [Nature] 2018 Aug; Vol. 560 (7717), pp. 253-257. Date of Electronic Publication: 2018 Aug 01.

Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.

Autor: Leaver DJ; Center for Chemical Biology and Department of Chemistry & Biochemistry, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA; Institute of Chemistry and Biomedical Sciences, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu, 210093, P.R. China., Patkar P; Center for Chemical Biology and Department of Chemistry & Biochemistry, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA., Singha UK; Department of Microbiology and Immunology, Meharry Medical College, 1005 Doctor D. B. Todd Jr. Boulevard, Nashville, TN 37208, USA., Miller MB; Center for Chemical Biology and Department of Chemistry & Biochemistry, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA., Haubrich BA; Center for Chemical Biology and Department of Chemistry & Biochemistry, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA., Chaudhuri M; Department of Microbiology and Immunology, Meharry Medical College, 1005 Doctor D. B. Todd Jr. Boulevard, Nashville, TN 37208, USA., Nes WD; Center for Chemical Biology and Department of Chemistry & Biochemistry, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA. Electronic address: wdavid.nes@ttu.edu.

Publikováno v: Chemistry & biology [Chem Biol] 2015 Oct 22; Vol. 22 (10), pp. 1374-83.