The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism

Autor: Anna Annunziata, Francesco Maria Fusco, Alessandro Di Minno, Margherita Ruoppolo, Giuseppe Castaldo, Chiara Dell’Isola, Roberta Russo, Armando Cevenini, Immacolata Andolfo, Mario Capasso, Giuseppe Fiorentino, Roberta Fedele, Gabriella Fabbrocini, Cecilia Calabrese, Marianna Caterino, Michele Costanzo, Ivan Gentile, Monica Gelzo, Roberto Parrella, Maurizio D’Abbraccio

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9548, p 9548 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 17; Pages: 9548

COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b401c6515ca4349d73cf653de0905a
http://europepmc.org/articles/PMC8431319

Dysregulation of lipid metabolism and pathological inflammation in patients with COVID-19

Autor: Gabriella Fabbrocini, Caterina Missero, Roberta Russo, Monica Gelzo, Aurora Daniele, Maurizio D’Abbraccio, Immacolata Andolfo, Giuseppe Castaldo, Marianna Caterino, Roberto Parrella, Mario Capasso, Chiara Dell’Isola, Stefano Sol, Giuseppe Fiorentino, Anna Annunziata, Ivan Gentile, Emanuela Marchese, Margherita Ruoppolo, Rita Polito, Cecilia Calabrese, Francesco Maria Fusco, Roberta Fedele, Michele Costanzo

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring acce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c86f87d239607227548efa816a6383
https://pubmed.ncbi.nlm.nih.gov/33536486

A comparison of fitting algorithms for diffusion-weighted MRI data analysis using an intravoxel incoherent motion model

Autor: Roberta Fusco, Mario Sansone, Antonella Petrillo

Publikováno v: Magnetic Resonance Materials in Physics, Biology and Medicine. 30:113-120

The objective of this study is to propose a modified VARiable PROjection (VARPRO) algorithm specifically tailored for fitting the intravoxel incoherent motion (IVIM) model to diffusion-weighted magnetic resonance imaging (DW-MRI) data from locally ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddcce7a6f42de8e35232e642227aabd
https://doi.org/10.1007/s10334-016-0591-y

Integrating omics datasets with the OmicsPLS package

Autor: Jeanine J. Houwing-Duistermaat, Szymon M. Kielbasa, Lucija Klaric, Said el Bouhaddani, Caroline Hayward, Geurt Jongbloed, Hae-Won Uh

Publikováno v: Bouhaddani, S E, Uh, H-W, Jongbloed, G, Hayward, C, Klarić, L, Kiełbasa, S M & Houwing-Duistermaat, J 2018, ' Integrating omics datasets with the OmicsPLS package ', BMC Bioinformatics, vol. 19, no. 1, pp. 371 . https://doi.org/10.1186/s12859-018-2371-3
BMC Bioinformatics
BMC Bioinformatics, 19(1)
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
BMC Bioinformatics, 19
BMC Bioinformatics, 19(1). BioMed Central

Background With the exponential growth in available biomedical data, there is a need for data integration methods that can extract information about relationships between the data sets. However, these data sets might have very different characteristi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16c728af3752bf96f9dab8f3875bbd0
https://hdl.handle.net/20.500.11820/be1ee6f6-5c8a-42ed-aa45-2429421858dd

Evolocumab and clinical outcomes in patients with cardiovascular disease

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Tokgozoglu, Sl, Toth, K, Viigimaa, M, Wan Ahmad WA, Hennekens, Ch, Andreotti, F, Baigent, C, Brown, Wv, Davis, Br, Newcomer, Jw, Wood, Sk, Larosa, J, Ansell, B, Olsson, A, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F, Silverman, S, Singhal, A, Vita, J, Mackinnon, I, Vogel, Dr, Leon de la Fuente, R, Perna, E, Amuchastegui, M, Pacora, F, Hershson, A, Blumberg, E, Glenny, Ja, Colombo, H, Cuadrado, Ja, Nicolosi, L, Rojas, Cg, Ulla, Mr, Hasbani, Eg, Cuneo, C, Lopez Santi RG, Sanabria, Hd, Hrabar, A, Lozada, A, Begg, A, Lehman, S, Wittert, G, Juergens, C, Kostner, K, Beltrame, J, Simpson, R, Sinhal, A, Adams, M, Kritharides, L, Roberts Thomson, P, Cross, D, Thompson, P, Van Gaal, W, Cox, N, Farshid, A, Hammett, C, Garrahy, P, Prasan, A, Horrigan, M, Ebenbichler, C, Hanusch, U, Prager, R, Schernthaner, G, Luger, A, Siostrzonek, P, Toplak, H, Bergler-Klein, J, Paulweber, B, Sinzinger, H, Buysschaert, 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Publikováno v: New England Journal of Medicine, Vol. 376, No 18 (2017) pp. 1713-1722
The New England journal of medicine, vol 376, iss 18

Background Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b5b917e3a0a9c0a2612b229ff4037e
http://hdl.handle.net/11365/1212875