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of 20
pro vyhledávání: '"Leasha J Schaub"'
Evaluation of prolonged ‘Permissive Hypotension’: results from a 6-hour hemorrhage protocol in swine
Autor:
Clifford G Morgan, Leslie E Neidert, Emily N Hathaway, Gerardo J Rodriguez, Leasha J Schaub, Sylvain Cardin, Jacob J Glaser
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 4, Iss 1 (2019)
Background Tactical Combat Casualty Care guidelines for hemorrhage recommend resuscitation to systolic blood pressure (SBP) of 85±5 mm Hg during prehospital care. Success depends on transport to definitive care within the ‘golden hour’. As futur
Externí odkaz:
https://doaj.org/article/ed71e98188f1479b980dd74e98fcea92
Autor:
Philip J Vernon, Leasha J Schaub, Jurandir J Dallelucca, Anthony E Pusateri, Forest R Sheppard
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0146105 (2015)
BACKGROUND:Maladaptive immune responses, particularly cytokine and chemokine-driven, are a significant contributor to the deleterious inflammation present in many types of injury and infection. Widely available applications to rapidly assess individu
Externí odkaz:
https://doaj.org/article/116f52c48fdf4a8bb51d7145d8f92c25
Autor:
Kapil N. Bhalla, James E. Bradner, Swaminathan P. Iyer, Jianting Sheng, Ming Zhan, Santhana G.T. Devaraj, Melissa Rodriguez, Bryce P. Portier, Karissa Peth, Bhavin Shah, Leasha J. Schaub, John A. Valenta, Jun Qi, Sunil Sharma, Warren Fiskus
PDF - 95K, Figure legends for the Supplemental Data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7e26a93b1586ac87ab171558f6128d
https://doi.org/10.1158/1535-7163.22501212.v1
https://doi.org/10.1158/1535-7163.22501212.v1
Autor:
Kapil N. Bhalla, James E. Bradner, Swaminathan P. Iyer, Jianting Sheng, Ming Zhan, Santhana G.T. Devaraj, Melissa Rodriguez, Bryce P. Portier, Karissa Peth, Bhavin Shah, Leasha J. Schaub, John A. Valenta, Jun Qi, Sunil Sharma, Warren Fiskus
The bromodomain and extra-terminal (BET) protein family members, including BRD4, bind to acetylated lysines on histones and regulate the expression of important oncogenes, for example, c-MYC and BCL2. Here, we demonstrate the sensitizing effects of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852ae1a9fc12f2161fed81c6ef04b0ac
https://doi.org/10.1158/1535-7163.c.6536709.v1
https://doi.org/10.1158/1535-7163.c.6536709.v1
Autor:
Kapil N. Bhalla, James E. Bradner, Swaminathan P. Iyer, Jianting Sheng, Ming Zhan, Santhana G.T. Devaraj, Melissa Rodriguez, Bryce P. Portier, Karissa Peth, Bhavin Shah, Leasha J. Schaub, John A. Valenta, Jun Qi, Sunil Sharma, Warren Fiskus
PDF - 352K, Supplemental Figure 1: Chemical structures of the molecules used in the studies. Supplemental Figure 2: Effects of (R)-JQ1 in AML cells. Supplemental Figure 3: ChIP of BRD4 and POLII in JQ1 treated AML cells. Supplemental Figure 4: JQ1 ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036b3b123800850bbad518342fd0c114
https://doi.org/10.1158/1535-7163.22501209.v1
https://doi.org/10.1158/1535-7163.22501209.v1
Autor:
Jacob J. Glaser, Kassandra M. Ozuna, Valerie G. Sams, Darren M. Fryer, Clifford G Morgan, Remealle A How, Leasha J. Schaub, Sylvain Cardin
Publikováno v:
Journal of Trauma and Acute Care Surgery. 87:68-75
Adenosine, lidocaine, and magnesium (ALM) is a cardioplegic agent shown to improve survival by improving cardiac function, tissue perfusion, and coagulopathy in animal models of shock. We hypothesized prehospital ALM treatment in hemorrhagic shock wo
Evaluation of prolonged ‘Permissive Hypotension’: results from a 6-hour hemorrhage protocol in swine
Autor:
Sylvain Cardin, Emily N Hathaway, Leslie E Neidert, Leasha J. Schaub, Clifford G Morgan, Jacob J. Glaser, Gerardo J. Rodriguez
Publikováno v:
Trauma Surgery & Acute Care Open
BackgroundTactical Combat Casualty Care guidelines for hemorrhage recommend resuscitation to systolic blood pressure (SBP) of 85±5 mm Hg during prehospital care. Success depends on transport to definitive care within the ‘golden hour’. As future
Autor:
Anne L. Slaughter, Hunter B. Moore, Christopher C. Silliman, Arsen Ghasabyan, Ernest E. Moore, Geoffrey R. Nunns, Anirban Banerjee, Forest R. Sheppard, Julie A. Reisz, Kirk C. Hansen, Miguel Fragoso, Angelo D'Alessandro, Leasha J. Schaub, James G. Chandler, Matthew J. Wither
Publikováno v:
Journal of Trauma and Acute Care Surgery. 84:537-541
BACKGROUND: Plasma levels of lactate and succinate are predictors of mortality in critically injured patients in military and civilian settings. In relative terms, these metabolic derangements have been recapitulated in rodent, swine and non-human pr
Autor:
Antoni R. Macko, Jacob J. Glaser, Forest R. Sheppard, Leasha J. Schaub, Andrew P. Cap, Thomas A. Mitchell
Publikováno v:
Transfusion. 59(7)
BACKGROUND Hemorrhage remains the primary cause of preventable death in civilian and military trauma. The Committee on Tactical Combat Casualty Care recommends prehospital (PH) resuscitation with whole blood (WB). However, 6% hetastarch in lactated e
Autor:
Forest R. Sheppard, Leasha J. Schaub, Andrew P. Cap, Antoni R. Macko, Cdr Jacob J Glaser, Hunter B. Moore, Ernest E. Moore
Publikováno v:
The journal of trauma and acute care surgery. 85(6)
INTRODUCTION The contributions of type and timing of fluid resuscitation to coagulopathy in trauma remain controversial. As part of a multifunctional resuscitation fluid research effort, we sought to further characterize the coagulation responses to