Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.

Autor: Welch GM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Boix CA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Schmauch E; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Davila-Velderrain J; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Victor MB; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Dileep V; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Bozzelli PL; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Su Q; Departments of Computational Biology and Biology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Cheng JD; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Lee A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Leary NS; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Pfenning AR; Departments of Computational Biology and Biology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Kellis M; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Publikováno v: Science advances [Sci Adv] 2022 Sep 30; Vol. 8 (39), pp. eabo4662. Date of Electronic Publication: 2022 Sep 28.