Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Leanne Wallace"'
Autor:
Anna Freydenzon, Marta F. Nabais, Tian Lin, Kelly L. Williams, Leanne Wallace, Anjali K. Henders, Ian P. Blair, Naomi R. Wray, Roger Pamphlett, Allan F. McRae
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Individuals encounter varying environmental exposures throughout their lifetimes. Some exposures such as smoking are readily observed and have high personal recall; others are more indirect or sporadic and might only be inferred from long oc
Externí odkaz:
https://doaj.org/article/2af8811ee1fb420aab5ac4855095106d
Autor:
Restuadi Restuadi, Frederik J. Steyn, Edor Kabashi, Shyuan T. Ngo, Fei-Fei Cheng, Marta F. Nabais, Mike J. Thompson, Ting Qi, Yang Wu, Anjali K. Henders, Leanne Wallace, Chris R. Bye, Bradley J. Turner, Laura Ziser, Susan Mathers, Pamela A. McCombe, Merrilee Needham, David Schultz, Matthew C. Kiernan, Wouter van Rheenen, Leonard H. van den Berg, Jan H. Veldink, Roel Ophoff, Alexander Gusev, Noah Zaitlen, Allan F. McRae, Robert D. Henderson, Naomi R. Wray, Jean Giacomotto, Fleur C. Garton
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-22 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a complex, late-onset, neurodegenerative disease with a genetic contribution to disease liability. Genome-wide association studies (GWAS) have identified ten risk loci to date, including the
Externí odkaz:
https://doaj.org/article/554d6d92682e49b2a277f81cb79542d2
Autor:
Divya Mehta, Karen Grewen, Brenda Pearson, Shivangi Wani, Leanne Wallace, Anjali K. Henders, Elisabeth B. Binder, Vibe G. Frokjaer, Samantha Meltzer-Brody, Naomi R. Wray, Alison M. Stuebe
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Maternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child health and well-being. In this study, we aimed to identify genes associated with PPD. To do this, we investig
Externí odkaz:
https://doaj.org/article/44c8166a241f4a09ab582073b142abaa
Autor:
Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kłoszewska, Bruno Vellas, the Australian Imaging Biomarkers and Lifestyle study, the Alzheimer’s Disease Neuroimaging Initiative, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter van Rheenen, Leonard H. van den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. McRae
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)
Abstract Background People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to e
Externí odkaz:
https://doaj.org/article/201eefeb04d04cf0871060b72f55eedd
Autor:
Chloe X. Yap, Gail A. Alvares, Anjali K. Henders, Tian Lin, Leanne Wallace, Alaina Farrelly, Tiana McLaren, Jolene Berry, Anna A. E. Vinkhuyzen, Maciej Trzaskowski, Jian Zeng, Yuanhao Yang, Dominique Cleary, Rachel Grove, Claire Hafekost, Alexis Harun, Helen Holdsworth, Rachel Jellett, Feroza Khan, Lauren Lawson, Jodie Leslie, Mira Levis Frenk, Anne Masi, Nisha E. Mathew, Melanie Muniandy, Michaela Nothard, Peter M. Visscher, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Helen S. Heussler, Andrew J. O. Whitehouse, Naomi R. Wray, Jacob Gratten
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose biological basis is yet to be elucidated. The Australian Autism Biobank (AAB) is an initiative of the Cooperative Research Centre for Living with Autis
Externí odkaz:
https://doaj.org/article/ae37a7b7214449059cff55591f8fa357
Autor:
Costanza L. Vallerga, Futao Zhang, Javed Fowdar, Allan F. McRae, Ting Qi, Marta F. Nabais, Qian Zhang, Irfahan Kassam, Anjali K. Henders, Leanne Wallace, Grant Montgomery, Yu-Hsuan Chuang, Steve Horvath, Beate Ritz, Glenda Halliday, Ian Hickie, John B. Kwok, John Pearson, Toni Pitcher, Martin Kennedy, Steven R. Bentley, Peter A. Silburn, Jian Yang, Naomi R. Wray, Simon J. G. Lewis, Tim Anderson, John Dalrymple-Alford, George D. Mellick, Peter M. Visscher, Jacob Gratten
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-anal
Externí odkaz:
https://doaj.org/article/8ab912eda75443699d2e15309d47801d
Autor:
Jacob J. Crouse, Joanne S. Carpenter, Frank Iorfino, Tian Lin, Nicholas Ho, Enda M. Byrne, Anjali K. Henders, Leanne Wallace, Daniel F. Hermens, Elizabeth M. Scott, Naomi R. Wray, Ian B. Hickie
Publikováno v:
BJPsych Open, Vol 7 (2021)
Background The schizophrenia polygenic risk score (SCZ-PRS) is an emerging tool in psychiatry. Aims We aimed to evaluate the utility of SCZ-PRS in a young, transdiagnostic, clinical cohort. Method SCZ-PRSs were calculated for young people who prese
Externí odkaz:
https://doaj.org/article/4bfbfcd63c4a4d65ad5c359711db86f7
Autor:
Gail A. Alvares, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Jacob Gratten, Rachel Grove, Anjali Henders, Helen Heussler, Lauren Lawson, Anne Masi, Emma Raymond, Felicity Rose, Leanne Wallace, Naomi R. Wray, Andrew J. O. Whitehouse, the Australian Autism Biobank team
Publikováno v:
BMC Pediatrics, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background The phenotypic and genetic heterogeneity of autism spectrum disorder (ASD) presents considerable challenges in understanding etiological pathways, selecting effective therapies, providing genetic counselling, and predicting clinic
Externí odkaz:
https://doaj.org/article/54b0bc0dcf8e424b936dd89074f7de91
Autor:
Catherine E Bond, Derek J Nancarrow, Leesa F Wockner, Leanne Wallace, Grant W Montgomery, Barbara A Leggett, Vicki L J Whitehall
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91739 (2014)
The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS) confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis. BRAF wild type cancers are typica
Externí odkaz:
https://doaj.org/article/815828ac81784e45b8f25feec3591261
Autor:
Anjali K. Henders, Pamela A. McCombe, Nigel G. Laing, Perminder S. Sachdev, Allan F. McRae, Garth A. Nicholson, Fleur C. Garton, Beben Benyamin, Wouter van Rheenen, Anna A. E. Vinkhuyzen, Frederik J. Steyn, Restuadi Restuadi, Leanne Wallace, Dominic B. Rowe, Susan Mathers, Robert D. Henderson, Zhihong Zhu, Shyuan T. Ngo, Kelly L. Williams, Tian Lin, Karen A. Mather, Ian P. Blair, Merrilee Needham, Naomi R. Wray, Roger Pamphlett, Peter M. Visscher
Publikováno v:
Eur J Hum Genet
Amyotrophic Lateral Sclerosis (ALS) is recognised to be a complex neurodegenerative disease involving both genetic and non-genetic risk factors. The underlying causes and risk factors for the majority of cases remain unknown; however, ever-larger gen