Výsledky vyhledávání - "Leanne Peiser"

Akademický článek

The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.

Autor: Congrong Niu, Christine M Livingston, Li Li, Rudolf K Beran, Stephane Daffis, Dhivya Ramakrishnan, Dara Burdette, Leanne Peiser, Eduardo Salas, Hilario Ramos, Mei Yu, Guofeng Cheng, Michel Strubin, William E Delaney, Simon P Fletcher

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0169648 (2017)

The structural maintenance of chromosome 5/6 complex (Smc5/6) is a restriction factor that represses hepatitis B virus (HBV) transcription. HBV counters this restriction by expressing HBV X protein (HBx), which targets Smc5/6 for degradation. However

Externí odkaz: https://doaj.org/article/289b65f6ddb14f2da1dab20a156f9d07

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In Vivo Cellular Expansion of Lisocabtagene Maraleucel and Association With Efficacy and Safety in Relapsed/Refractory Large B‐Cell Lymphoma

Autor: Ken Ogasawara, James Lymp, Timothy Mack, Justine Dell’Aringa, Chang‐pin Huang, Jeff Smith, Leanne Peiser, Ana Kostic

Publikováno v: Clinical Pharmacology & Therapeutics. 112:81-89

Lisocabtagene maraleucel (liso-cel) is an autologous, CD19-directed, chimeric antigen receptor T-cell product for the treatment of adult patients with relapsed or refractory large B-cell lymphoma (LBCL) after 2 or more lines of systemic therapy. In v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edffb981a877d766cd4ce8af7555e98
https://doi.org/10.1002/cpt.2561

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Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

Autor: Leanne Peiser, Jessica Davies, Divya Pattabiraman, Ruth Chu, Simon P. Fletcher, Oliver E. Amin, Emily J. Colbeck, Laura J. Pallett, William Rosenberg, Hassan Javanbakht, Sophie Lehar, Mala K. Maini, Christian R. Frey, Shahzada Khan, Holly Micolochick Steuer, Dhivya Ramakrishnan, Stephane Daffis, Adam Palazzo

Publikováno v: Hepatology (Baltimore, Md.)

Background and aims GS-9688 (selgantolimod) is a toll-like receptor 8 agonist in clinical development for the treatment of chronic hepatitis B (CHB). Antiviral activity of GS-9688 has previously been evaluated in vitro in HBV-infected hepatocytes and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06186dd4f42c9e4f3b2e604b979501fa
https://doi.org/10.1002/hep.31695

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Characteristics of Post-Infusion Chimeric Antigen Receptor (CAR) T Cells and Endogenous T Cells Associated with Early and Long-Term Response in Lisocabtagene Maraleucel (liso-cel)-Treated Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)

Autor: Yue Jiang, Ana Kostic, Leanne Peiser, Yeonhee Kim, Jerill Thorpe, Julie Rytlewski

Publikováno v: Blood. 138:3834-3834

Background: Liso-cel is an autologous, CD19-directed, defined composition, 4-1BB CAR T cell product administered at equal target doses of CD8 + and CD4 + CAR + T cells. In the pivotal TRANSCEND NHL 001 study (NCT02631044) in patients (pts) with R/R L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81a99cae898b21961459ef901672a306
https://doi.org/10.1182/blood-2021-151790

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449 Concurrent ibrutinib enhances T cell function in patients with chronic lymphocytic leukemia (CLL) treated with lisocabtagene maraleucel (liso-cel), a chimeric antigen receptor (CAR) T cell therapy

Autor: Diana Shpektor, Eniko Papp, Leanne Peiser, Jerill Thorpe, Yeonhee Kim, Julie A. Rytlewski, Heidi H. Gillenwater, Ken Ogasawara

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCLL is an incurable hematologic malignancy characterized by progressive accumulation of clonally derived CD19+ B-cell lymphocytes. CAR T cell therapies are promising treatments but inherent T cell dysfunction has limited their development i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9386318fd117d8ab60fdad94cbcf2b4b
https://doi.org/10.1136/jitc-2021-sitc2021.449

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106 Treatment with CC-99282 enhances antitumor function of the anti-CD19 CAR T cell therapy lisocabtagene maraleucel (liso-cel)

Autor: Jim Qin, Yue Jiang, Leanne Peiser, Brook Barajas, Susan Kim, Archana Brahmandam, Soraya Carrancio

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundLiso-cel, an autologous, CD19-directed, defined composition, 4-1BB CAR T cell product administered at equal target doses of CD8+ and CD4+ CAR+ T cells, has demonstrated efficacy and a favorable safety profile in adult patients with third-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91465721ae792dec100bbce60bcc1ed5
https://doi.org/10.1136/jitc-2021-sitc2021.106

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Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype

Autor: Siamon Gordon, Leanne Peiser, Subhankar Mukhopadhyay

Innate and adaptive immune activation of macrophages (Mφ) by microorganisms and antigen-activated lymphoid cells, respectively, plays an important role in host defense and immunopathology. Antigen-presenting cells express a range of pattern recognit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33482e9e18ded54fd03d0142136b315
https://ora.ox.ac.uk/objects/uuid:0cf0e06e-aa20-4a6b-a2eb-3593696199b8

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