Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Leanne M. Johnson"'
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 4, Pp 423-433 (2012)
Psoriasis vulgaris is a chronic, debilitating skin disease that affects millions of people worldwide. There is no mouse model that accurately reproduces all facets of the disease, but the accessibility of skin tissue from patients has facilitated the
Externí odkaz:
https://doaj.org/article/81a02edd9b354d9083647876243f13fb
Autor:
Leanne M Johnson-Huang, Cara A Pensabene, Kejal R Shah, Katherine C Pierson, Toyoko Kikuchi, Tim Lentini, Patricia Gilleaudeau, Mary Sullivan-Whalen, Inna Cueto, Artemis Khatcherian, Luke A Hyder, Mayte Suárez-Fariñas, James G Krueger, Michelle A Lowes
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30308 (2012)
UnlabelledTo understand the development of new psoriasis lesions, we studied a group of moderate-to-severe psoriasis patients who experienced a relapse after ceasing efalizumab (anti-CD11a, Raptiva, Genentech). There were increased CD3(+) T cells, ne
Externí odkaz:
https://doaj.org/article/3578f6aa939e4e8fb1132dc90435b9aa
Autor:
Pamela Aubert, Mayte Suárez-Fariñas, Hiroshi Mitsui, Leanne M Johnson-Huang, Jamie Lynn Harden, Katherine C Pierson, Joseph G Dolan, Inna Novitskaya, Israel Coats, Jacob Estes, Edward W Cowen, Nicole Plass, Chyi-Chia Richard Lee, Hong-Wei Sun, Michelle A Lowes, Raphaela Goldbach-Mansky
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49408 (2012)
The autoinflammatory disorder, Neonatal-onset Multisystem Inflammatory Disease (NOMID) is the most severe phenotype of disorders caused by mutations in CIAS1 that result in increased production and secretion of active IL-1β. NOMID patients present w
Externí odkaz:
https://doaj.org/article/8a9aeb4526b5468588188cde3238cfac
Autor:
Mayte Suárez-Fariñas, Michelle A. Lowes, Leanne M. Johnson-Huang, Jamie L. Harden, Steven M. Lewis, Samantha R. Lish, James G. Krueger, Daniel S. Gareau, Tim Lentini
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:1830-1840
Background Many human diseases arise from or have pathogenic contributions from a dysregulated immune response. One pathway with immunomodulatory ability is the tryptophan metabolism pathway, which promotes immune suppression through the enzyme indol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4b2105f8e8628dcc6c857a797d64e5
https://doi.org/10.1016/j.jaci.2015.09.055
https://doi.org/10.1016/j.jaci.2015.09.055
Autor:
Michelle A. Lowes, Narat John Eungdamrong, Jamie L. Harden, Nicholas Gulati, Judilyn Fuentes-Duculan, Luke A. Hyder, Juana Gonzalez, Katherine C. Pierson, Leanne M. Johnson-Huang, Lisa C. Zaba, Tim Lentini, Mayte Suárez-Fariñas
Publikováno v:
The Journal of investigative dermatology
Our group recently described a population of antigen-presenting cells that appear to be critical in psoriasis pathogenesis, termed inflammatory myeloid dendritic cells (CD11c(+)/blood dendritic cell (DC) antigen 1(-)). Triggering receptor expressed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ca8b0d3203f41fa0fb79246b22a0d7
Autor:
Judilyn Fuentes-Duculan, Mary Sullivan-Whalen, Michelle A. Lowes, Patricia Gilleaudeau, Milène Kennedy Crispin, Nicholas Gulati, Inna Cueto, James G. Krueger, Mayte Suárez-Fariñas, Leanne M. Johnson-Huang, Tim Lentini
Publikováno v:
Journal of Investigative Dermatology. 133(3):692-701
The acute response of human skin to UVB radiation has not been fully characterized. We sought to define the cutaneous response at 24 hours following narrowband UVB (NB-UVB, 312-nm peak), a therapeutically relevant source of UVB, using transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1202e1b073c7fe8c1c665a451c69ec1
Autor:
Mayte Suárez-Fariñas, Mary Sullivan-Whalen, Judilyn Fuentes-Duculan, Katherine C. Pierson, Tim Lentini, Asifa Haider, Michelle A. Lowes, Leanne M. Johnson-Huang, James G. Krueger, Patricia Gilleaudeau, Inna Cueto
Publikováno v:
The Journal of investigative dermatology
Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5779c814acf4d8e53582c0977d90864
https://doi.org/10.1038/jid.2011.458
https://doi.org/10.1038/jid.2011.458
Autor:
Mayte Suárez-Fariñas, Erika Billick, Hiroshi Mitsui, Nicholas Gulati, James G. Krueger, Milène Kennedy-Crispin, Leanne M. Johnson-Huang, Mary Sullivan-Whalen, Hideki Fujita, Patricia Gilleaudeau
Publikováno v:
The Journal of investigative dermatology
In the early stages of wound healing, keratinocytes become “activated” and release inflammatory molecules such as interleukin-1 and interleukin-8 that are linked to innate immune responses and neutrophil recruitment. It is unclear, however, wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96af52310325aa55257e13a9d702f7c4
Autor:
Julia S. Pettersen, Claire Q.F. Wang, John A. Carucci, Mark J. Bluth, Judilyn Fuentes-Duculan, Michelle A. Lowes, Linda Fan, Alexander Pitts-Kiefer, Daniel A. Belkin, James G. Krueger, Katherine C. Pierson, Leanne M. Johnson-Huang, Mayte Suárez-Fariñas, Shivaprasad Bhuvanendran
Publikováno v:
Journal of Investigative Dermatology. 131:1322-1330
Tumor-associated macrophages (TAMs) may have an important role in tumor immunity. We studied the activation state of TAMs in cutaneous SCC, the second most common human cancer. CD163 was identified as a more abundant, sensitive, and accurate marker o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55821f747031808cf69ee1cd26e21bd2
https://doi.org/10.1038/jid.2011.9
https://doi.org/10.1038/jid.2011.9
Autor:
Leanne M. Johnson, Phillip Scott
Publikováno v:
The Journal of Immunology. 178:7259-7266
The generation of Th1 responses is important for resistance to intracellular pathogens, including the parasite, Leishmania major. Although IFN-γR/STAT1 signaling promotes a Th1 response via the up-regulation of T-bet, the requirement for STAT1 in Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0a8598170b0669e5ded7b78c1e2784
https://doi.org/10.4049/jimmunol.178.11.7259
https://doi.org/10.4049/jimmunol.178.11.7259