Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Leanne K. Hein"'
Autor:
Sanjna Singh, Julien Bensalem, Leanne K. Hein, Aaron Casey, Ville-Petteri Mäkinen, Timothy J. Sargeant
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract The efficient removal of apoptotic cells via efferocytosis is critical for maintaining optimal tissue function. This involves the binding and engulfment of apoptotic cells by phagocytes and the subsequent maturation of the phagosome, culmina
Externí odkaz:
https://doaj.org/article/db48dae77e834310a2649823011a623b
Autor:
Aaron E. Casey, Wenjun Liu, Leanne K. Hein, Timothy J. Sargeant, Stephen M. Pederson, Ville-Petteri Mäkinen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Autophagy is an intracellular recycling process that degrades harmful molecules and enables survival during starvation, with implications for diseases including dementia, cancer and atherosclerosis. Previous studies demonstrate how a limited
Externí odkaz:
https://doaj.org/article/fdb2a38e9a854cb4ab315aec591c7e90
Autor:
Lauren S. Whyte, Célia Fourrier, Sofia Hassiotis, Adeline A. Lau, Paul J. Trim, Leanne K. Hein, Kathryn J. Hattersley, Julien Bensalem, John J. Hopwood, Kim M. Hemsley, Timothy J. Sargeant
Publikováno v:
IBRO Neuroscience Reports, Vol 12, Iss , Pp 131-141 (2022)
Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer’s disease (AD), which appear early and are progressive in nature. Sandhoff disease and Tay-Sachs disease (neurological lysosomal storage diseases caused by mutation
Externí odkaz:
https://doaj.org/article/d1d4403666e2493b96517b7138797dcc
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1691-1697 (2013)
Bis(monoacylglycero)phosphate (BMP) assists lysosomal function by facilitating interaction of hydrolases and activator proteins with sphingolipid substrates. Impaired lysosomal degradation of the sphingolipid glucosylceramide (GC) occurs in Gaucher d
Externí odkaz:
https://doaj.org/article/4b14dac719f6427a949918db6f06c6ab
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 8, Pp 1725-1734 (2008)
The formation of cholesterol and sphingolipids into specialized liquid-ordered membrane microdomains (rafts) has been proposed to function in the intracellular sorting and transport of proteins and lipids. Defined by biochemical criteria, rafts resis
Externí odkaz:
https://doaj.org/article/b0a6fd0c79ce4b5b8ab36fca496b40fd
Autor:
Julien Bensalem, Leanne K. Hein, Sofia Hassiotis, Paul J. Trim, Christopher G. Proud, Leonie K. Heilbronn, Timothy J. Sargeant
Publikováno v:
The Journal of Nutrition. 153:1407-1419
Autor:
John B. Bruning, Timothy J. Sargeant, Sean J. Humphrey, Jianling Xie, Wenru Pan, Leanne K. Hein, Christopher G. Proud, Luke A. Selth, Stuart P. De Poi
Publikováno v:
Cellular and Molecular Life Sciences. 78:4035-4052
The mechanistic target of rapamycin complex 1 (mTORC1) is an important regulator of cellular metabolism that is commonly hyperactivated in cancer. Recent cancer genome screens have identified multiple mutations in Ras-homolog enriched in brain (Rheb)
Autor:
Lauren S, Whyte, Célia, Fourrier, Sofia, Hassiotis, Adeline A, Lau, Paul J, Trim, Leanne K, Hein, Kathryn J, Hattersley, Julien, Bensalem, John J, Hopwood, Kim M, Hemsley, Timothy J, Sargeant
Publikováno v:
IBRO neuroscience reports. 12
Lysosomal network abnormalities are an increasingly recognised feature of Alzheimer's disease (AD), which appear early and are progressive in nature. Sandhoff disease and Tay-Sachs disease (neurological lysosomal storage diseases caused by mutations
Autor:
Kathryn J. Hattersley, Julian M. Carosi, Leanne K. Hein, Timothy J. Sargeant, Julien Bensalem
Publikováno v:
Biochemical and biophysical research communications. 570
Degradation and clearance of cellular waste in the autophagic and endo-lysosomal systems is important for normal physiology and prevention of common late-onset diseases such as Alzheimer's disease (AD). Phosphatidylinostol-binding clathrin assembly p
Autor:
Julian M. Carosi, Kathryn J. Hattersley, Julien Bensalem, Timothy J. Sargeant, Leonie K. Heilbronn, Randall H. Grose, Sofia Hassiotis, Célia Fourrier, Leanne K. Hein, Xiao Tong Teong
Publikováno v:
Autophagy
Autophagic flux is a critical cellular process that is vastly under-appreciated in terms of its importance to human health. Preclinical studies have demonstrated that reductions in autophagic flux cause cancer and exacerbate chronic diseases, includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c805b12c2cb8c43b93a097a20d47f93
https://hdl.handle.net/11541.2/145225
https://hdl.handle.net/11541.2/145225