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pro vyhledávání: '"Leanne K Saxon"'
Autor:
Behzad Javaheri, Andrew Sunters, Gul Zaman, Rosemary F L Suswillo, Leanne K Saxon, Lance E Lanyon, Joanna S Price
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35726 (2012)
Although Lrp5 is known to be an important contributor to the mechanisms regulating bone mass, its precise role remains unclear. The aim of this study was to establish whether mutations in Lrp5 are associated with differences in the growth and/or apop
Externí odkaz:
https://doaj.org/article/6f5d8c4da1e54e549ee463df8aa0b3e0
Autor:
Alesha B. Castillo, Alexander G. Robling, Subburaman Mohan, Charles H. Turner, Leanne K. Saxon
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E484-E491
Mechanical loading caused by physical activity can stimulate bone formation and strengthen the skeleton. Estrogen receptors (ERs) play some role in the signaling cascade that is initiated in bone cells after a mechanical load is applied. We hypothesi
Autor:
Leanne K. Saxon, Charles H. Turner
Publikováno v:
Bone. 39:1261-1267
Estrogen and exercise influence cortical bone formation. Both affect bone during growth, but with complex interactions. We hypothesized that estrogen reduces the osteogenic response caused by exercise at the periosteal surface of bone, while it enhan
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 290:E1034-E1040
Women are at greater risk of tearing their knee anterior cruciate ligament (ACL) than men participating in similar athletic activities. There is currently no conclusive explanation for this disparity; however, as ACL injuries in women have been linke
Publikováno v:
Bone. 36:454-464
After the initial adaptation to large mechanical loads, it appears as though the skeleton's responsiveness to exercise begins to wane. To counteract the waning effects of long-term mechanical loading, "time off" may be needed to improve the responsiv
Autor:
Alexander G. Robling, Jennifer L. Schriefer, Stuart J. Warden, Leanne K. Saxon, Charles H. Turner
Publikováno v:
Journal of biomechanics. 38(9)
Several mathematical rules by which bone adapts to mechanical loading have been proposed. Previous work focused mainly on negative feedback models, e.g., bone adapts to increased loading after a minimum strain effective (MES) threshold has been reach
Autor:
Leanne K. Saxon, Charles H. Turner
Publikováno v:
Bone. 38:290