Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Leanne E. Felkin"'
Autor:
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a pro-fibrotic gene network regulated by WWP2, a E3 ubiquitin ligase, which orchestrates the nucleocytoplasmic shutt
Externí odkaz:
https://doaj.org/article/cfb1b8ece2684ea692a537c58f79dad3
Autor:
Matthias Heinig, Michiel E. Adriaens, Sebastian Schafer, Hanneke W. M. van Deutekom, Elisabeth M. Lodder, James S. Ware, Valentin Schneider, Leanne E. Felkin, Esther E. Creemers, Benjamin Meder, Hugo A. Katus, Frank Rühle, Monika Stoll, François Cambien, Eric Villard, Philippe Charron, Andras Varro, Nanette H. Bishopric, Alfred L. George, Cristobal dos Remedios, Aida Moreno-Moral, Francesco Pesce, Anja Bauerfeind, Franz Rüschendorf, Carola Rintisch, Enrico Petretto, Paul J. Barton, Stuart A. Cook, Yigal M. Pinto, Connie R. Bezzina, Norbert Hubner
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-21 (2017)
Abstract Background Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. Results Here we report the first in-depth survey of heart
Externí odkaz:
https://doaj.org/article/8e7bacbcd5ca43fa9bd815bc4899b453
Autor:
Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/28195d5a2cfd4a2ca91a728a572eb369
Autor:
Daniel Reichart, Eric L. Lindberg, Henrike Maatz, Antonio M. A. Miranda, Anissa Viveiros, Nikolay Shvetsov, Anna Gärtner, Emily R. Nadelmann, Michael Lee, Kazumasa Kanemaru, Jorge Ruiz-Orera, Viktoria Strohmenger, Daniel M. DeLaughter, Giannino Patone, Hao Zhang, Andrew Woehler, Christoph Lippert, Yuri Kim, Eleonora Adami, Joshua M. Gorham, Sam N. Barnett, Kemar Brown, Rachel J. Buchan, Rasheda A. Chowdhury, Chrystalla Constantinou, James Cranley, Leanne E. Felkin, Henrik Fox, Ahla Ghauri, Jan Gummert, Masatoshi Kanda, Ruoyan Li, Lukas Mach, Barbara McDonough, Sara Samari, Farnoush Shahriaran, Clarence Yapp, Caroline Stanasiuk, Pantazis I. Theotokis, Fabian J. Theis, Antoon van den Bogaerdt, Hiroko Wakimoto, James S. Ware, Catherine L. Worth, Paul J. R. Barton, Young-Ae Lee, Sarah A. Teichmann, Hendrik Milting, Michela Noseda, Gavin Y. Oudit, Matthias Heinig, Jonathan G. Seidman, Norbert Hubner, Christine E. Seidman
Publikováno v:
Science
Science 377:eabo1984 (2022)
Science 377:eabo1984 (2022)
INTRODUCTION Human heart failure is a highly morbid condition that affects 23 million individuals worldwide. It emerges in the setting of an array of different cardiovascular disorders, which has propelled the notion that diverse stimuli converge on
Autor:
Daniel N. Meijles, Susanna T. E. Cooper, Peter E. Glennon, John Sembrat, Spencer Shaw, Leanne E. Felkin, Angela Clerk, Mauricio Rojas, Peter H. Sugden, Thomais Markou, Sam J. Leonard, M. N. Sheppard, K. Vanezis, Michelle A. Hardyman, Owen J. L. Rackham, Joshua J Cull, Paul J.R. Barton, Charles F. McTiernan, S A Cook, Sonia Chothani, Stephen J. Fuller, Hajed O. Alharbi
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121752225409a1c8d37392fa7f2ed3a0
https://doi.org/10.1101/2021.08.14.455637
https://doi.org/10.1101/2021.08.14.455637
Autor:
Angela Clerk, Daniel N. Meijles, Michelle A. Hardyman, Stephen J. Fuller, Sonia P. Chothani, Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Konstantinos Vanezis, Leanne E. Felkin, Thomais Markou, Samuel J. Leonard, Spencer W. Shaw, Owen J.L. Rackham, Stuart A. Cook, Peter E. Glennon, Mary N. Sheppard, John C. Sembrat, Mauricio Rojas, Charles F. McTiernan, Paul J. Barton, Peter H. Sugden
Publikováno v:
The Biochemical journal. 479(3)
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Autor:
Sonia Chothani, Leroy S. Pakkiri, Robert George Edward Holgate, Stuart A. Cook, Anissa A. Widjaja, Leanne E. Felkin, Joyce Sze Yuin Goh, Jin Zhou, Jessie Tan, Shamini Guna Shekeran, Brijesh K. Singh, James W. Dear, Chester L. Drum, Paul M. Yen, Mao Wang, Arron Hearn, Sivakumar Viswanathan, Eleonora Adami, Jinrui Dong, Benjamin K Ng, Sze Yun Lim, Sebastian Schafer, W. Lim
Publikováno v:
Widjaja, A A, Dong, J, Adami, E, Viswanathan, S, Ng, B K, Pakkiri, L S, Chothani, S P, Singh, B K, Lim, W W, Zhou, J, Shekeran, S G, Tan, J, Lim, S Y, Goh, J, Wang, M, Holgate, R, Hearn, A, Felkin, L E, Yen, P M, Dear, J W, Drum, C L, Schafer, S & Cook, S A 2021, ' Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury ', Science Translational Medicine . https://doi.org/10.1126/scitranslmed.aba8146
Acetaminophen (N-acetyl-p-aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9637aaa604b680452bf1c8c6b7f9c92
https://hdl.handle.net/20.500.11820/df15ad75-899e-473e-b005-40028e26382b
https://hdl.handle.net/20.500.11820/df15ad75-899e-473e-b005-40028e26382b
Autor:
K Thomson, Pantazis I. Theotokis, Antonio de Marvao, Mian Ahmad, Risha Govind, Alicja Wilk, Sanjay K Prasad, Nicola Whiffin, Alexander Ing, Stuart A. Cook, Francesco Mazzarotto, David Sim, A. John Baksi, Upasana Tayal, Elizabeth Edwards, Leanne E. Felkin, Angharad M. Roberts, Iacopo Olivotto, Declan P. O'Regan, Antonis Pantazis, Rachel Buchan, James S. Ware, Laura Lihua Chan, Roddy Walsh, William Midwinter, Timothy J W Dawes, Erica Mazaika, Paul J.R. Barton, Hugh Watkins, Birgit Funke
Publikováno v:
Circulation
Circulation, 141(5), 387-398. Lippincott Williams and Wilkins
Circulation, 141(5), 387-398. Lippincott Williams and Wilkins
Supplemental Digital Content is available in the text.
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6d5f50cc6112a9c66a70ac46ac1400
http://hdl.handle.net/11379/545740
http://hdl.handle.net/11379/545740
Autor:
Robert George Edward Holgate, Sze-Yun Lim, Brijesh K. Singh, James W. Dear, W. Lim, Chester L. Drum, Anissa A. Widjaja, Benjamin Ng, Sebastian Schafer, Jin Zhou, Mao Wang, Shamini Guna Shekeran, Arron Hearn, Paul M. Yen, Leanne E. Felkin, Tan J, Leroy S. Pakkiri, Sonia Chothani, Stuart A. Cook, Sivakumar Viswanathan, Eleonora Adami, Jinrui Dong
Acetaminophen (APAP) overdose is a leading cause of untreatable liver failure. In the mouse model of APAP-induced liver injury (AILI), the administration of recombinant human interleukin 11 (rhIL11) is protective. Here we show that the beneficial eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d2b32885c7514d123a8bb837a48caf
https://doi.org/10.1101/830018
https://doi.org/10.1101/830018
Autor:
Leanne E. Felkin, Kirill Shkura, Elisabeth Tan, Nithya Devapragash, Nathan Harmston, Aida Moreno-Moral, Leonardo Bottolo, Maxime Rotival, Owen J. L. Rackham, Prashant K. Srivastava, Gianni D Angelini, Cristina Beltrami, Costanza Emanueli, Francesco Pesce, Xi-Ming Sun, Huimei Chen, Enrique Lara-Pezzi, Norbert Hubner, Wei-Ping Yu, Michal Pravenec, Ee Ling Heng, Stuart A. Cook, Enrico Petretto, Paul J.R. Barton, Massimiliano Mancini, Sebastian Schafer, Nicole Tee
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Cardiac fibrosis is a final common pathology in inherited and acquired heart diseases that causes cardiac electrical and pump failure. Here, we use systems genetics to identify a pro-fibrotic gene network in the diseased heart and show that this netw