Hypothesis: Are Neoplastic Macrophages/Microglia Present in Glioblastoma Multiforme?

Autor: Leanne C Huysentruyt, Zeynep Akgoc, Thomas N Seyfried

Publikováno v: ASN Neuro, Vol 3 (2011)

Most malignant brain tumours contain various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. These cells are generally considered part of the tumour stroma and are often described as TAM (tumour-associated macr

Externí odkaz: https://doaj.org/article/b7155c2da898419aad159518980c9c0b

Distinct patterns of HIV-1 evolution within metastatic tissues in patients with non-Hodgkins lymphoma.

Autor: Marco Salemi, Susanna L Lamers, Leanne C Huysentruyt, Derek Galligan, Rebecca R Gray, Alanna Morris, Michael S McGrath

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8153 (2009)

Despite highly active antiretroviral therapy (HAART), AIDS related lymphoma (ARL) occurs at a significantly higher rate in patients infected with the Human Immunodeficiency Virus (HIV) than in the general population. HIV-infected macrophages are a kn

Externí odkaz: https://doaj.org/article/8c046912b473493f8b6341b56e0fab42

Perspectives on the mesenchymal origin of metastatic cancer

Autor: Leanne C. Huysentruyt, Thomas N. Seyfried

Publikováno v: Cancer Metastasis Reviews
Huysentruyt, Leanne C.; & Seyfried, Thomas N.(2010). Perspectives on the mesenchymal origin of metastatic cancer. Cancer and Metastasis Reviews, 29(4), pp 695-707. doi: 10.1007/s10555-010-9254-z. Retrieved from: http://www.escholarship.org/uc/item/7wc625ws

Emerging evidence suggests that many metastatic cancers arise from cells of the myeloid/macrophage lineage regardless of the primary tissue of origin. A myeloid origin of metastatic cancer stands apart from origins involving clonal evolution or epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc964874bfc7f2f4a2963dfe9059a1da
http://europepmc.org/articles/PMC2962789

Influence of methotrexate and cisplatin on tumor progression and survival in the VM mouse model of systemic metastatic cancer

Autor: Laura M. Shelton, Thomas N. Seyfried, Leanne C. Huysentruyt

Publikováno v: International Journal of Cancer. 126:65-72

We recently identified a new tumor (VM-M3), which arose spontaneously in the brain of an inbred VM mouse. When grown outside the brain, the VM-M3 tumor expresses all major biological processes of metastasis to include local invasion, intravasation, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6addb9d2c31c7b8f8256341cc60785
https://doi.org/10.1002/ijc.24649

Up-regulation of NG2 proteoglycan and interferon-induced transmembrane proteins 1 and 3 in mouse astrocytoma: A membrane proteomics approach

Autor: Leanne C. Huysentruyt, Nicholas T. Seyfried, Thomas N. Seyfried, Qiangwei Xia, Ron Orlando, James Atwood

Publikováno v: Cancer Letters. 263:243-252

Although brain tumors are classified as if their lineage were well understood, the relationship between the molecular events that specify neural cell lineage and brain tumors remains enigmatic. Traditionally, cell surface membrane antigens have serve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311f81fa56a2f8956d381a146c26ea17
https://doi.org/10.1016/j.canlet.2008.01.007