Výsledky vyhledávání - "Leanne Bassett"

Reprint of 'Non-invasive measure of respiratory mechanics and conventional respiratory parameters in conscious large animals by high frequency Airwave Oscillometry'

Autor: Eric Troncy, Simon Authier, Thomas F. Schuessler, Alexis Ascah, Mylene Pouliot, Leanne Bassett, Annette Robichaud

Publikováno v: Journal of Pharmacological and Toxicological Methods. 70:283-286

Introduction A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (V t ), respiratory rate (RR) or minute ven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ee5351b7db29fd9e93a251b96685cf
https://doi.org/10.1016/j.vascn.2014.10.003

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Telemetry video-electroencephalography (EEG) in rats, dogs and non-human primates: Methods in follow-up safety pharmacology seizure liability assessments

Autor: Dominique Paquette, Eric Troncy, Simon Authier, Alexis Ascah, Leanne Bassett, Mylene Pouliot

Publikováno v: Journal of Pharmacological and Toxicological Methods. 70:230-240

Introduction Non-clinical seizure liability studies typically aim to: 1) confirm the nature of EEG activity during abnormal clinical signs, 2) identify premonitory clinical signs, 3) measure plasma levels at seizure onset, 4) demonstrate that drug-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a053925c44f7d4701960336bc6efb089
https://doi.org/10.1016/j.vascn.2014.07.005

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Reprint of 'Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys'

Autor: Simon Authier, Leanne Bassett, Mylene Pouliot, Adeline Rachalski, Eric Troncy, Dominique Paquette, Valérie Mongrain

Publikováno v: Journal of Pharmacological and Toxicological Methods. 70:287-294

Medication-induced sleep disturbances are a major concern in drug development as a multitude of prescription drugs alter sleep patterns, often negatively. Polysomnography is used in clinical diagnostics but is also applicable to animal models. Rodent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f394a977999f7c6e5f45483ecc571b59
https://doi.org/10.1016/j.vascn.2014.10.004

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Sleep electroencephalographic characteristics of the Cynomolgus monkey measured by telemetry

Autor: Adeline Rachalski, Simon Authier, Leanne Bassett, Mylene Pouliot, Valérie Mongrain, Gaétan Tremblay

Publikováno v: Journal of Sleep Research. 23:619-627

Cynomolgus monkeys are widely used as models of diseases and in pre-clinical studies to assess the impact of new pharmacotherapies on brain function and behaviour. However, the time course of electroencephalographic delta activity during sleep, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433f61ac4de910a686cbcd0163244667
https://doi.org/10.1111/jsr.12189

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Respiratory mechanics: Comparison of Beagle dogs, Göttingen minipigs and Cynomolgus monkeys

Autor: Thomas F. Schuessler, Geoffrey Truchetti, Leslie G. Gold, Annette Robichaud, Eric Troncy, Simon Authier, Leanne Bassett, Said Maghezzi

Publikováno v: Journal of Pharmacological and Toxicological Methods. 70:48-54

Introduction When the no observed adverse effect level (NOAEL) is determined by respiratory safety pharmacology, follow-up studies are warranted and may include airway resistance and compliance. Respiratory mechanics in commonly used large animal spe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192cb53f9e45222e5b16d5086b5b4960
https://doi.org/10.1016/j.vascn.2014.03.171

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Effects of amphetamine, diazepam and caffeine on polysomnography (EEG, EMG, EOG)-derived variables measured using telemetry in Cynomolgus monkeys

Autor: Leanne Bassett, Eric Troncy, Adeline Rachalski, Dominique Paquette, Simon Authier, Mylene Pouliot, Valérie Mongrain

Publikováno v: Journal of pharmacological and toxicological methods. 70(1)

Introduction : Medication-induced sleep disturbances are a major concern in drug development as a multitude of prescription drugs alter sleep patterns, often negatively. Polysomnography is used in clinical diagnostics but is also applicable to animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e575a93d8563ea2ab819d985b8528f28
https://pubmed.ncbi.nlm.nih.gov/25467813

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Non-invasive measure of respiratory mechanics and conventional respiratory parameters in conscious large animals by high frequency Airwave Oscillometry

Autor: Leanne Bassett, Eric Troncy, Annette Robichaud, Thomas F. Schuessler, Mylène Pouliot, Alexis Ascah, Simon Authier

Publikováno v: Journal of pharmacological and toxicological methods. 70(1)

A number of drugs in clinical trials are discontinued due to potentially life-threatening airway obstruction. As some drugs may not cause changes in core battery parameters such as tidal volume (Vt), respiratory rate (RR) or minute ventilation (MV),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341f633706863b18b4baf3fcb43cf1cc
https://pubmed.ncbi.nlm.nih.gov/25467812

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