Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Leanna Whitmore"'
Autor:
Samuel Martin-Vilchez, Leanna Whitmore, Hannelore Asmussen, Jessica Zareno, Rick Horwitz, Karen Newell-Litwa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170464 (2017)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether upstream RhoGTPase regulators,
Externí odkaz:
https://doaj.org/article/483608b0e4d246cab67933410726fa5d
Autor:
Karen Newell-Litwa, Hannelore Asmussen, Mathilde Badoual, Heather Patel, Leanna Whitmore, Alan Rick Horwitz
Publikováno v:
The Journal of Cell Biology
ROCK1 forms the stable actomyosin filament bundles that initiate front–back and dendritic spine polarity, while ROCK2 regulates contractile force, Rac1 activity, and cofilin-mediated actin remodeling at the leading edge of migratory cells and the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8db9203146e93a747ef01a3cc079bd3
http://europepmc.org/articles/PMC4508895
http://europepmc.org/articles/PMC4508895
Autor:
Karen Newell-Litwa, Leanna Whitmore, Hannelore Asmussen, Jessica Zareno, Rick Horwitz, Samuel Martin-Vilchez
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170464 (2017)
PLoS ONE
PLoS ONE
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether upstream RhoGTPase regulators,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e7b59a27cef7037d1c1f271644c590
http://europepmc.org/articles/PMC5256999?pdf=render
http://europepmc.org/articles/PMC5256999?pdf=render
Autor:
Alan F. Horwitz, Leanna Whitmore, Miguel Vicente-Manzanares, Marcelo Lazzaron Lamers, Margaret A. Koach
Publikováno v:
The Journal of Cell Biology
We have found that MLC-dependent activation of myosin IIB in migrating cells is required to form an extended rear, which coincides with increased directional migration. Activated myosin IIB localizes prominently at the cell rear and produces large, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3982f6e93ce09cba44311bf13c5d1c14
https://doi.org/10.1083/jcb.200806030
https://doi.org/10.1083/jcb.200806030
Autor:
Leanna Whitmore, Colin K. Choi, Alex Mogilner, Jessica Zareno, Miguel Vicente-Manzanares, Alan Rick Horwitz
Publikováno v:
Nature Cell Biology. 10:1039-1050
Using two-colour imaging and high resolution TIRF microscopy, we investigated the assembly and maturation of nascent adhesions in migrating cells. We show that nascent adhesions assemble and are stable within the lamellipodium. The assembly is indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07468a3e8ee47940ec2b568b6672d2c
https://doi.org/10.1038/ncb1763
https://doi.org/10.1038/ncb1763
Publikováno v:
The Journal of Cell Biology
We have used isoform-specific RNA interference knockdowns to investigate the roles of myosin IIA (MIIA) and MIIB in the component processes that drive cell migration. Both isoforms reside outside of protrusions and act at a distance to regulate cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d838d3361e2ca59e1c081669af85640
https://doi.org/10.1083/jcb.200612043
https://doi.org/10.1083/jcb.200612043
Autor:
Donna J, Webb, Melanie J, Schroeder, Cynthia J, Brame, Leanna, Whitmore, Jeffrey, Shabanowitz, Donald F, Hunt, A Rick, Horwitz
Publikováno v:
Journal of Cell Science. 118:4925-4929
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add7263af6ef4cf325ae256571dd8170
https://doi.org/10.1242/jcs.02563
https://doi.org/10.1242/jcs.02563
Autor:
Leanna Whitmore, Alan F. Horwitz, Donna J. Webb, Karen Donais, Sheila M. Thomas, J. Thomas Parsons, Christopher E. Turner
Publikováno v:
Nature Cell Biology. 6:154-161
Cell migration is a complex, highly regulated process that involves the continuous formation and disassembly of adhesions (adhesion turnover). Adhesion formation takes place at the leading edge of protrusions, whereas disassembly occurs both at the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59840386ed2096d1e46dd96ac5c1d5c7
https://doi.org/10.1038/ncb1094
https://doi.org/10.1038/ncb1094
Autor:
Alan Rick Horwitz, Jennifer L. Hodges, Leanna Whitmore, Hannelore Asmussen, Samuel Martin Vilchez
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101770 (2014)
PLoS ONE
PLoS ONE
Dendritic spines are micron-sized protrusions that constitute the primary post-synaptic sites of excitatory neurotransmission in the brain. Spines mature from a filopodia-like protrusion into a mushroom-shaped morphology with a post-synaptic density
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b847ac305d471313b28f4c39cc41fd7
http://europepmc.org/articles/PMC4090192?pdf=render
http://europepmc.org/articles/PMC4090192?pdf=render
Autor:
Alexia I. Bachir, Miguel Vicente-Manzanares, Leanna Whitmore, Karen Newell-Litwa, Alan Rick Horwitz
Publikováno v:
The Journal of Cell Biology
Myosin IIA and IIB synergistically generate front–back polarity through their effects on actomyosin bundling formation and stability, and adhesion maturation, which are mediated by localized Rac GEF depletion.
Migratory front–back polarity e
Migratory front–back polarity e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a741d4e9e9bd568de222ea58b83c80
https://pubmed.ncbi.nlm.nih.gov/21482721
https://pubmed.ncbi.nlm.nih.gov/21482721