Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leanna S. Morinishi"'
Autor:
Michael Ramirez, Satwik Rajaram, Robert J. Steininger, Daria Osipchuk, Maike A. Roth, Leanna S. Morinishi, Louise Evans, Weiyue Ji, Chien-Hsiang Hsu, Kevin Thurley, Shuguang Wei, Anwu Zhou, Prasad R. Koduru, Bruce A. Posner, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Cancer cells that survive initial drug treatment can persist in the presence of drugs. Here, the authors generate persister cells that are resistant to the EGFR tyrosine kinase inhibitor erlotinib and show by single cell analysis that multiple mechan
Externí odkaz:
https://doaj.org/article/bd1a3c50ad1a402d9bff233756a1c84e
Autor:
David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://doaj.org/article/120375a9425d4b15800ba82e59af4543
Autor:
David Mavor, Kyle Barlow, Samuel Thompson, Benjamin A Barad, Alain R Bonny, Clinton L Cario, Garrett Gaskins, Zairan Liu, Laura Deming, Seth D Axen, Elena Caceres, Weilin Chen, Adolfo Cuesta, Rachel E Gate, Evan M Green, Kaitlin R Hulce, Weiyue Ji, Lillian R Kenner, Bruk Mensa, Leanna S Morinishi, Steven M Moss, Marco Mravic, Ryan K Muir, Stefan Niekamp, Chimno I Nnadi, Eugene Palovcak, Erin M Poss, Tyler D Ross, Eugenia C Salcedo, Stephanie K See, Meena Subramaniam, Allison W Wong, Jennifer Li, Kurt S Thorn, Shane Ó Conchúir, Benjamin P Roscoe, Eric D Chow, Joseph L DeRisi, Tanja Kortemme, Daniel N Bolon, James S Fraser
Publikováno v:
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Externí odkaz:
https://doaj.org/article/f3e8373dbc7b4012a1c82425c9fb49fb
Publikováno v:
Cell systems, vol 11, iss 1
Cell Syst
Cell Syst
SummaryA persistent puzzle in cancer biology is how mutations, which neither alter canonical growth signaling pathways nor directly interfere with drug mechanism, can still recur and persist in tumors. One notable example is the loss-of-function muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d108fdf535f57243696578ea29283b9
https://escholarship.org/uc/item/7fj905b3
https://escholarship.org/uc/item/7fj905b3
Publikováno v:
Current Opinion in Systems Biology. 10:1-8
Drug-insensitive tumor subpopulations remain a significant barrier to effective cancer treatment. Recent works suggest that within isogenic drug-sensitive cancer populations, subsets of cells can enter a ‘persister’ state allowing them to survive
Autor:
Danielle L. Swaney, Alexander M. Wolff, Tamas L. Nagy, Douglas Myers-Turnbull, Douglas R. Wassarman, Kyle A. Barlow, Paul V. Thomas, Rachel M. Brunetti, Derek Britain, Kevin Lou, Sy Redding, Wesley M. Marin, Mary K. Tsai, Kurt S. Thorn, Ryan W. Tibble, Lillian R. Kenner, Daniel M. C. Schwarz, Charlotte A. Nelson, Bruk Mensa, Fatima S. Ugur, Derek Bogdanoff, Taia S. Wu, E. Kang, Nicholas J. Rettko, Leanna S. Morinishi, Peter F. McTigue, Martin Kampmann, Gabriel K. Reder, Eric D. Chow, Alison M Maxwell, Jason Town, James S. Fraser, Andrew M. Natale, David P. Bauer, Cole Helsell, Joseph L. DeRisi, Yuliya Birman, Pooja Suresh, Evan M. Green, Ruilin Tian, Jennifer Y. Li, Sergei Pourmal, Weilin Chen, Hiten D. Madhani, Daniel N. Bolon, Miles Sasha Dickinson, Shane O’Conchúir, Keely Oltion, Daniel Asarnow, Peter J. Rohweder, Susanna K. Elledge, David Mavor, Erin M. Poss, Matvei S. Khoroshkin, Beatrice Ary, Ian D. Bergman, Nadja Kern, Taylor Arhar, Lisa L. Kirkemo, Tanja Kortemme, Sophia K. Tan, Shizhong Dai, Greyson R. Lewis, Nathan L. Hendel, Cynthia M. Chio
Publikováno v:
Biology Open
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Biology open, vol 7, iss 7
Biology Open, Vol 7, Iss 7 (2018)
Mavor, D; Barlow, KA; Asarnow, D; Birman, Y; Britain, D; Chen, W; et al.(2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. BIOLOGY OPEN, 7(7). doi: 10.1242/bio.036103. UCSF: Retrieved from: http://www.escholarship.org/uc/item/2hz894gr
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Autor:
Nadja Kern, Taylor Arhar, Matvei S. Khoroshkin, Ian D. Bergman, Lisa L. Kirkemo, Danielle L. Swaney, Nathan L. Hendel, Jason Town, Weilin Chen, Lillian R. Kenner, Alexander M. Wolff, Wesley M. Marin, Rachel M. Brunetti, Charlotte A. Nelson, Susanna K. Elledge, Sergei Pourmal, Greyson R. Lewis, Cynthia M. Chio, Derek Britain, Derrick Bogdanoff, Andrew M. Natale, Shane O’Conchúir, Martin Kampmann, Douglas R. Wassarmann, Kyle A. Barlow, Bruk Mensa, Gabriel K. Reder, Kurt S. Thorn, Ryan W. Tibble, Pooja Suresh, Sy Redding, Keely Oltion, Tanja Kortemme, James S. Fraser, Daniel Asarnow, Evan M. Green, Fatima S. Ugur, David L.V. Bauer, Sophia K. Tan, Joseph L. DeRisi, Beatrice Ary, Yuliya Birman, Tamas L. Nagy, Daniel N. Bolon, Miles Sasha Dickinson, Taia Wu, K. Tsai, Peter F. McTigue, Ruilin Tian, Nicholas J. Rettko, Shizhong Dai, Hiten D. Madhani, Jennifer Y. Li, Douglas Myers-Turnbull, Kevin Lou, Peter J. Rohweder, David Mavor, Daniel M. C. Schwarz, Alison M Maxwell, Erin M. Poss, Cole Helsell, E. Kang, Leanna S. Morinishi, Paul Thomas, Eric D. Chow
Although the primary protein sequence of ubiquitin (Ub) is extremely stable over evolutionary time, it is highly tolerant to mutation during selection experiments performed in the laboratory. We have proposed that this discrepancy results from the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb1693458a8341e04b43f423acafd0d
Autor:
Clinton L. Cario, Seth D. Axen, Weiyue Ji, Kurt S. Thorn, Adolfo Cuesta, Daniel N. Bolon, Kaitlin R. Hulce, Kyle A. Barlow, Marco Mravic, Jennifer X. Li, Lillian R. Kenner, Garrett Gaskins, Eugenia C Salcedo, Elena L. Caceres, David Mavor, Stefan Niekamp, Allison W. Wong, Weilin Chen, Bruk Mensa, Samuel Thompson, Benjamin A Barad, Erin M. Poss, Ryan K Muir, Rachel E. Gate, Laura Deming, Zairan Liu, Shane Ó Conchúir, Joseph L. DeRisi, Meena Subramaniam, James S. Fraser, Evan M. Green, Eugene Palovcak, Tanja Kortemme, Tyler D Ross, Alain R Bonny, Steven M. Moss, Stephanie K. See, Chimno I Nnadi, Benjamin P. Roscoe, Leanna S. Morinishi, Eric D. Chow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a8a47dec29f83dc18d99f9ad48e8e5
https://doi.org/10.7554/elife.15802.023
https://doi.org/10.7554/elife.15802.023
Autor:
Marco Mravic, Chimno I Nnadi, Weiyue Ji, Benjamin P. Roscoe, Benjamin A Barad, Clinton L. Cario, Meena Subramaniam, Bruk Mensa, Ryan K Muir, Weilin Chen, Jennifer X. Li, Leanna S. Morinishi, Adolfo Cuesta, Daniel N. Bolon, Garrett Gaskins, Rachel E. Gate, Lillian R. Kenner, Kyle A. Barlow, Stefan Niekamp, Allison W. Wong, Tanja Kortemme, Eric D. Chow, Alain R Bonny, Joseph L. DeRisi, Zairan Liu, Shane Ó Conchúir, Kurt S. Thorn, Samuel Thompson, Seth D. Axen, Eugenia C Salcedo, Stephanie K. See, Kaitlin R. Hulce, Erin M. Poss, Elena L. Caceres, James S. Fraser, Eugene Palovcak, Laura Deming, David Mavor, Tyler D Ross, Evan M. Green, Steven M. Moss
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance
Autor:
Shuguang Wei, Kevin Thurley, Steven J. Altschuler, Weiyue Ji, Anwu Zhou, Maike A. Roth, Chien Hsiang Hsu, Robert J. Steininger, Prasad Koduru, Michael Ramirez, Bruce A. Posner, Daria Osipchuk, Louise Evans, Satwik Rajaram, Lani F. Wu, Leanna S. Morinishi
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Cancer therapy has traditionally focused on eliminating fast-growing populations of cells. Yet, an increasing body of evidence suggests that small subpopulations of cancer cells can evade strong selective drug pressure by entering a ‘persister' sta