Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leann Miles"'
Autor:
Shannon Trombley, Jackson Powell, Pavithran Guttipatti, Andrew Matamoros, Xiaohui Lin, Tristan O’Harrow, Tobias Steinschaden, Leann Miles, Qin Wang, Shuchao Wang, Jingyun Qiu, Qingyang Li, Feng Li, Yuanquan Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract A neuron’s regenerative capacity is governed by its intrinsic and extrinsic environment. Both peripheral and central neurons exhibit cell-type-dependent axon regeneration, but the underlying mechanism is unclear. Glia provide a milieu esse
Externí odkaz:
https://doaj.org/article/5aace61cd9da4162adbb3e05ecf7e974
Autor:
Feng Li, Tsz Y. Lo, Leann Miles, Qin Wang, Harun N. Noristani, Dan Li, Jingwen Niu, Shannon Trombley, Jessica I. Goldshteyn, Chuxi Wang, Shuchao Wang, Jingyun Qiu, Katarzyna Pogoda, Kalpana Mandal, Megan Brewster, Panteleimon Rompolas, Ye He, Paul A. Janmey, Gareth M. Thomas, Shuxin Li, Yuanquan Song
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The Atr-Check1 pathway is involved in cell cycle and the DNA damage response. Here, the authors show that the Atr-Check1 pathway can inhibit axon regeneration in response to Piezo-mediated mechanosensation, affecting functional recovery.
Externí odkaz:
https://doaj.org/article/005c24fb0ae4423db9855a4fda43b7ac
Autor:
Megan Brewster, Shuxin Li, Tsz Y. Lo, Jessica I. Goldshteyn, Leann Miles, Katarzyna Pogoda, Paul A. Janmey, Dan Li, Jingyun Qiu, Panteleimon Rompolas, Koushik Mandal, Gareth M. Thomas, Qin Wang, Yuanquan Song, Shannon Trombley, Shuchao Wang, Ye He, Chuxi Wang, Feng Li, Jingwen Niu, Harun N. Noristani
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e023285b7caa9e596dddd550e52ec3d1
https://doi.org/10.1038/s41467-021-24131-7
https://doi.org/10.1038/s41467-021-24131-7
Publikováno v:
The Neuroscientist. :107385842210885
Cells sense and respond to mechanical stimuli by converting those stimuli into biological signals, a process known as mechanotransduction. Mechanotransduction is essential in diverse cellular functions, including tissue development, touch sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988cf9950f5c8a474e6a56b21761e628
https://doi.org/10.1177/10738584221088575
https://doi.org/10.1177/10738584221088575
Autor:
Jessica I. Goldshteyn, Megan Brewster, Katarzyna Pogoda, Ye He, Jingwen Niu, Chuxi Wang, Paul A. Janmey, Feng Li, Dan Li, Tsz Y. Lo, Yuanquan Song, Qin Wang, Leann Miles, Shannon Trombley, Jingyun Qiu, Panteleimon Rompolas, Gareth M. Thomas, Shuchao Wang
Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5082723e8c7b0e007489f0fb182adad6
https://doi.org/10.1101/2020.06.03.132126
https://doi.org/10.1101/2020.06.03.132126
Autor:
Swetha E. Murthy, Fei Wang, Bertrand Coste, Nikita Yakubovich, Sung-Eun Kim, Olivia Farrelly, Yang Xiang, Feng Li, Panteleimon Rompolas, Tsz Y. Lo, Ardem Patapoutian, Katherine L. Thompson-Peer, Yuanquan Song, Yuh Nung Jan, Leann Miles, Tun Li, Dan Li, Jiaxin Gong, Lily Yeh Jan
Publikováno v:
Neuron
Neuron, Elsevier, 2019, 102 (2), pp.373-389.e6. ⟨10.1016/j.neuron.2019.01.050⟩
Neuron, 2019, 102 (2), pp.373-389.e6. ⟨10.1016/j.neuron.2019.01.050⟩
Neuron, vol 102, iss 2
Neuron, Elsevier, 2019, 102 (2), pp.373-389.e6. ⟨10.1016/j.neuron.2019.01.050⟩
Neuron, 2019, 102 (2), pp.373-389.e6. ⟨10.1016/j.neuron.2019.01.050⟩
Neuron, vol 102, iss 2
Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca2+-permeable non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe83ac931275f6a46d36b97951670ee
https://hal-amu.archives-ouvertes.fr/hal-02553101
https://hal-amu.archives-ouvertes.fr/hal-02553101
Autor:
Meredith E. Jackrel, Lance Bigelow, Grigore D. Pintilie, Wah Chiu, Karolina Michalska, Edward Chuang, Zachary M. March, Catherine Hatzos-Skintges, Leann Miles, Laura M. Castellano, Kaiming Zhang, James Shorter, Andrzej Joachimiak, Robert Jedrzejczak
Summary Hsp104 is an AAA+ protein disaggregase with powerful amyloid-remodeling activity. All nonmetazoan eukaryotes express Hsp104 while eubacteria express an Hsp104 ortholog, ClpB. However, most studies have focused on Hsp104 from Saccharomyces cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ceefca0d6b9e0c033c3aebb90f1268c
https://europepmc.org/articles/PMC6403000/
https://europepmc.org/articles/PMC6403000/