Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leandro Z. Agudelo"'
Autor:
Duarte M. S. Ferreira, Arthur J. Cheng, Leandro Z. Agudelo, Igor Cervenka, Thomas Chaillou, Jorge C. Correia, Margareta Porsmyr-Palmertz, Manizheh Izadi, Alicia Hansson, Vicente Martínez-Redondo, Paula Valente-Silva, Amanda T. Pettersson-Klein, Jennifer L. Estall, Matthew M. Robinson, K. Sreekumaran Nair, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-19 (2019)
Abstract Background Skeletal muscle mass and strength are crucial determinants of health. Muscle mass loss is associated with weakness, fatigue, and insulin resistance. In fact, it is predicted that controlling muscle atrophy can reduce morbidity and
Externí odkaz:
https://doaj.org/article/2f827301045e4b2e8bc503169f19361b
Autor:
Leandro Z. Agudelo, Duarte M. S. Ferreira, Shamim Dadvar, Igor Cervenka, Lars Ketscher, Manizheh Izadi, Liu Zhengye, Regula Furrer, Christoph Handschin, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitoc
Externí odkaz:
https://doaj.org/article/4a97fef9ea204ae2827332216ca511a8
Autor:
Richard Mills, Hermes Taylor-Weiner, Jorge C. Correia, Leandro Z. Agudelo, Ilary Allodi, Christina Kolonelou, Vicente Martinez-Redondo, Duarte M.S. Ferreira, Susanne Nichterwitz, Laura H. Comley, Vanessa Lundin, Eva Hedlund, Jorge L. Ruas, Ana I. Teixeira
Publikováno v:
Molecular Metabolism, Vol 7, Iss , Pp 12-22 (2018)
Objective: We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. Methods: A microfluidic device was used to model endocrine signaling and NMJ formation betwee
Externí odkaz:
https://doaj.org/article/db87ccbfe02748bf8d9b5cf1f96d5cac
Autor:
Jorge C. Correia, Julie Massart, Jan Freark de Boer, Margareta Porsmyr-Palmertz, Vicente Martínez-Redondo, Leandro Z. Agudelo, Indranil Sinha, David Meierhofer, Vera Ribeiro, Marie Björnholm, Sascha Sauer, Karin Dahlman-Wright, Juleen R. Zierath, Albert K. Groen, Jorge L. Ruas
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 891-902 (2015)
Objective: Farnesoid X receptor (FXR) plays a prominent role in hepatic lipid metabolism. The FXR gene encodes four proteins with structural differences suggestive of discrete biological functions about which little is known. Methods: We expressed ea
Externí odkaz:
https://doaj.org/article/8ebda816bd19486b9e767bdbd21f6a38
Autor:
Yosuke Tanigawa, Jiekun Yang, Päivi Pajukanta, Maria Vamvini, Laurie J. Goodyear, Manolis Kellis, Roeland J.W. Middelbeek, Kiki Galani, Leandro Z. Agudelo, Markku Laakso, Kevin L. Grove, Pasquale Nigro, Li-Lun Ho, Marcus Alvarez
Regular physical exercise has long been recognized to reverse the effects of diet-induced obesity, but the molecular mechanisms mediating these multi-tissue beneficial effects remain uncharacterized. Here, we address this challenge by studying the op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fa52d28e5e2106a254fa43d5c414dfc
https://doi.org/10.1101/2021.11.22.469622
https://doi.org/10.1101/2021.11.22.469622
Autor:
Jochen M. Schwenk, Ana Viñuela, Ian M Forgie, Hugo Pomares-Millan, Timothy J. McDonald, Andrea Mari, Jerzy Adamski, Juan Fernandez Tajes, Søren Brunak, Konstantinos D. Tsirigos, Harriet Teare, Andrea Tura, Hartmut Ruetten, E. Louise Thomas, Mattias Ohlsson, Robert W. Koivula, Federico De Masi, Henrik Vestergaard, Ramneek Gupta, Petra J. M. Elders, Giuseppe N. Giordano, Joline W. Beulens, Anubha Mahajan, Torben Hansen, Tarja Kokkola, Andrew T. Hattersley, Paul W. Franks, Alison Heggie, Martin Ridderstråle, Elizaveta Chabanova, Mark Walker, Daniel Coral, Henna Cederberg, Tue H. Hansen, Jagadish Vangipurapu, Naeimeh Atabaki-Pasdar, Leandro Z. Agudelo, Emmanouil T. Dermitzakis, Imre Pavo, Andrew A. Brown, Jimmy D. Bell, Markku Laakso, Femke Rutters, Ewan R. Pearson, Oluf Pedersen, Kristine H. Allin, Sabine van Oort, Mark I. McCarthy, Angus G. Jones, Donna McEvoy
Type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) often co-occur. Defining causal pathways underlying this relationship may help optimize the prevention and treatment of both diseases. Thus, we assessed the strength and magnitude of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dc9e3d2f7a2b057c79495472154aa2d
https://doi.org/10.1101/2021.08.31.21262709
https://doi.org/10.1101/2021.08.31.21262709
Autor:
Jiekun Yang, Maria Vamvini, Pasquale Nigro, Li-Lun Ho, Kyriakitsa Galani, Marcus Alvarez, Yosuke Tanigawa, Ashley Renfro, Nicholas P. Carbone, Markku Laakso, Leandro Z. Agudelo, Päivi Pajukanta, Michael F. Hirshman, Roeland J.W. Middelbeek, Kevin Grove, Laurie J. Goodyear, Manolis Kellis
Publikováno v:
Cell Metabolism. 34:1578-1593.e6
Exercise training is critical for the prevention and treatment of obesity, but its underlying mechanisms remain incompletely understood given the challenge of profiling heterogeneous effects across multiple tissues and cell types. Here, we address th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0772338f5a7040c260366e52d957b4
https://doi.org/10.1016/j.cmet.2022.09.004
https://doi.org/10.1016/j.cmet.2022.09.004
Autor:
Leandro Z. Agudelo, Teresa Femenía, Suvi Linna-Kuosmanen, Na Sun, Claudia Llinares, Yongjin Park, Burak Kutlu, Kevin L. Grove, Li Lun Ho, Manolis Kellis, Naeimeh Atabaki-Pasdar, Rémy Tuyéras, Galani K, Alvaro Morcuende, Paul W. Franks
Metabolism plays a central role in evolution, as resource conservation is a selective pressure for fitness and survival. Resource-driven adaptations offer a good model to study evolutionary innovation more broadly. It remains unknown how resource-dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f599e82e3d8aaff5946818b645d910c9
https://doi.org/10.21203/rs.3.rs-716965/v1
https://doi.org/10.21203/rs.3.rs-716965/v1
Autor:
Lindsey K. Stolze, Elamaran Meibalan, Juho Jalkanen, Minna U. Kaikkonen, Lei Hou, Pasi Tavi, Leandro Z. Agudelo, Tiit Örd, Manolis Kellis, Casey E. Romanoski, S. Linna-Kuosmanen, Jarmo Gunn, Anu Toropainen, Mantero Jc, Galani K, Guillermo García-Cardeña, Renfro A, Calum A. MacRae, E. Schmauch, Carles Boix, Ojanen J, Maija Hollmén, Tuomas Kiviniemi
Ischemic heart disease is the single most common cause of death worldwide with an annual death rate of over 9 million people. Genome-wide association studies have uncovered over 200 genetic loci underlying the disease, providing a deeper understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6cca2d8cc683661bf76311024e01800
https://doi.org/10.1101/2021.06.23.449672
https://doi.org/10.1101/2021.06.23.449672
Autor:
Christoph Handschin, Marius Brazaitis, Tomas Venckunas, Igor Cervenka, Shamim Dadvar, Duarte M. S. Ferreira, Regula Furrer, Liu Zhengye, Lars Ketscher, Jorge L. Ruas, Johanna T. Lanner, Leandro Z. Agudelo, Manizheh Izadi, Sigitas Kamandulis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983debdc6c07968c54ef411cb494b72f
http://link.springer.com/article/10.1038/s41467-019-10712-0
http://link.springer.com/article/10.1038/s41467-019-10712-0