Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Leandro N Marziali"'
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Akademický článek
A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communication.
Autor: Ghjuvan'Ghjacumu Shackleford, Leandro N Marziali, Yo Sasaki, Anke Claessens, Cinzia Ferri, Nadav I Weinstock, Alexander M Rossor, Nicholas J Silvestri, Emma R Wilson, Edward Hurley, Grahame J Kidd, Senthilvelan Manohar, Dalian Ding, Richard J Salvi, M Laura Feltri, Maurizio D'Antonio, Lawrence Wrabetz
Publikováno v: PLoS Genetics, Vol 18, Iss 11, p e1010477 (2022)
Myelin is essential for rapid nerve impulse propagation and axon protection. Accordingly, defects in myelination or myelin maintenance lead to secondary axonal damage and subsequent degeneration. Studies utilizing genetic (CNPase-, MAG-, and PLP-null
Externí odkaz: https://doaj.org/article/3727869bf2534264a552e58bc6edf603
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3
YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration
Autor: Sophie Belin, Yannick Poitelon, Abigail Hellman, Leandro N. Marziali, Jacob Herron, Ashley M. Kopec, Urja Bhatia, Haley Jeanette, Maria Laura Feltri
Publikováno v: Glia
YAP and TAZ are effectors of the Hippo pathway that controls multicellular development by integrating chemical and mechanical signals. Peripheral nervous system development depends on the Hippo pathway. We previously showed that loss of YAP and TAZ i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d351570bfa894fc07e397fa6676ece21
http://europepmc.org/articles/PMC7898398
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4
Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and abnormal neural stem cell development
Autor: Zhen Yan, James P. Catlin, Benjamin Rein, Leandro N. Marziali, M. Laura Feltri, Christine E. Schaner Tooley
Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
N-terminal methylation is an important posttranslational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, and transcriptional regulation. Our generation of a const
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abde8b4ac4bfff21c482d1a8c43e0752
https://doi.org/10.1038/s41419-021-04316-0
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5
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells
Autor: Lawrence Wrabetz, Bin He, Bogdan Beirowski, Gustavo Della-Flora Nunes, Leandro N. Marziali, Emma R. Wilson, Bert W. O'Malley, Yannick Poitelon, M. Laura Feltri, Edward Hurley, Nicholas Silvestri
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
In peripheral nerves, Schwann cells form myelin and provide trophic support to axons. We previously showed that the mitochondrial protein prohibitin 2 can localize to the axon-Schwann-cell interface and is required for developmental myelination. Whet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c098be287b2f4d181bfdbc5319e4f5
https://doi.org/10.1038/s41467-021-23552-8
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6
Age-related neurodegeneration and cognitive impairments of NRMT1 knockout mice are preceded by misregulation of RB and expansion of the neural stem cell population
Autor: Maria Laura Feltri, Leandro N. Marziali, James P. Catlin, Schaner Tooley Ce, Benjamin Rein, Zhen Yan
N-terminal methylation is an important post-translational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, and transcriptional regulation. Our generation of a cons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ad5c792011af7e688ccd924259e2d8b
https://doi.org/10.1101/2021.03.15.435479
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7
The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells
Autor: Pablo M. Paez, Juana M. Pasquini, Veronica T. Cheli, Norma N. Zamora, Vilma Spreuer, Diara A. Santiago González, María E. Guitart, Leandro N. Marziali
Publikováno v: The Journal of Neuroscience. 38:9142-9159
The divalent metal transporter 1 (DMT1) is a multimetal transporter with a primary role in iron transport. Although DMT1 has been described previously in the CNS, nothing was known about the role of this metal transporter in oligodendrocyte maturatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29281ba3aa4cb4277326242eaf631a1
https://doi.org/10.1523/jneurosci.1447-18.2018
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8
Iron Availability Compromises Not Only Oligodendrocytes But Also Astrocytes and Microglial Cells
Autor: María E. Guitart, Jorge Correale, Leandro N. Marziali, Mariana Puntel, Juana M. Pasquini, Fernando Juan Pitossi, Maria Victoria Rosato-Siri, Maria Elvira Badaracco
Publikováno v: Molecular Neurobiology. 55:1068-1081
When disrupted, iron homeostasis negatively impacts oligodendrocyte (OLG) differentiation and impairs myelination. To better understand myelin formation and OLG maturation, in vivo and in vitro studies were conducted to evaluate the effect of iron de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ec49cf19bd6a781365b04c723c58ac
https://doi.org/10.1007/s12035-016-0369-2
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9
Combination therapy of apo-transferrin and thyroid hormones enhances remyelination
Autor: Jorge Correale, Maria Victoria Rosato-Siri, Vanesa S. Mattera, Leandro N. Marziali, Juana M. Pasquini
Publikováno v: GliaREFERENCES. 69(1)
The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays were conducted to determine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852bcec978b6959aaeac2d541425ace5
https://pubmed.ncbi.nlm.nih.gov/32818301
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10
Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development
Autor: Charles ffrench-Constant, Ernest Arenas, Leandro N. Marziali, Maqsood Ahmed, M. Laura Feltri
Publikováno v: Ahmed, M, Marziali, L N, Arenas, E, Feltri, M L & ffrench-Constant, C 2019, ' Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development ', Development, vol. 146, no. 16, dev172668 . https://doi.org/10.1242/dev.172668
Development of the central nervous system requires coordination of the proliferation and differentiation of neural stem cells. Here, we show that laminin alpha 2 (lm-α2) is a component of the midbrain dopaminergic neuron (mDA) progenitor niche in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674c83f0c579c9adab7b553e8024fbfe
https://europepmc.org/articles/PMC6737905/
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