Výsledky vyhledávání - "Leandro Matías Sommese"

Akademický článek

CardIAP: calcium transients confocal image analysis tool

Autor: Ana Julia Velez Rueda, Luis Alberto Gonano, Agustín García Smith, Gustavo Parisi, María Silvina Fornasari, Leandro Matías Sommese

Publikováno v: Frontiers in Bioinformatics, Vol 3 (2023)

One of the main topics of cardiovascular research is the study of calcium (Ca2+) handling, as even small changes in Ca2+ concentration can alter cell functionality (Bers, Annu Rev Physiol, 2014, 76, 107–127). Ionic calcium (Ca2+) plays the role of

Externí odkaz: https://doaj.org/article/505ad2137f0649e180c513117e0726bd

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Akademický článek

Correlation of SARS-CoV-2 Viral Load and Clinical Evolution of Pediatric Patients in a General Hospital From Buenos Aires, Argentina

Autor: Martín Eduardo Brizuela, Sandra Elizabeth Goñi, Georgina Alexandra Cardama, María Alejandra Zinni, Alejandro Andres Castello, Leandro Matías Sommese, Hernán Gabriel Farina

Publikováno v: Frontiers in Pediatrics, Vol 10 (2022)

BackgroundSARS-CoV-2 infection is associated with a wide range of clinical manifestations and severity. Pediatric cases represent

Externí odkaz: https://doaj.org/article/01fc499d8f5b4757b611dca61f59e5fe

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Structural and evolutionary analysis unveil functional adaptations in the promiscuous behavior of serum albumins

Autor: Gustavo Parisi, Nicolas Palopoli, Luis E. Iglesias, Leandro Matías Sommese, Sebastián M. Ardanaz, Ana Julia Velez Rueda, Estefanía L. Borucki, Guillermo Ignacio Benitez

Publikováno v: Biochimie. 197

Promiscuous activities have been related to the capacity to catalyze reactions different from those a protein has evolved to sustain. In this work, we rethought the serum albumin's promiscuous behavior using evolutionary and structural analysis. We f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b606756fc9f8bef8afb4646779217bb
https://pubmed.ncbi.nlm.nih.gov/35183673

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Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

Autor: Enrique Leo Portiansky, Francisco J. Alvarado, Marcia A. Kaetzel, John R. Dedman, Julieta Palomeque, Carolina Natalia Zanuzzi, Alicia Mattiazzi, Marilén Federico, Xander H.T. Wehrens, Leandro Matías Sommese, P.G. Blanco

Publikováno v: The Journal of Physiology. 595:4089-4108

Background The impact of cardiac apoptosis in pre-diabetic stages of diabetic cardiomyopathy is unknown. We described that myocytes from fructose-rich diet (FRD) animals exhibit arrhythmias produced by exacerbated Ca2+/calmodulin-protein kinase (CaMK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f506195dc766a48337e35fe66bbf3b2
https://doi.org/10.1113/jp273714

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ProtMiscuity: a database of promiscuous proteins

Autor: Nicolas Palopoli, Matias Zacarias, Leandro Matías Sommese, Gustavo Parisi, Ana Julia Velez Rueda

Publikováno v: Database: The Journal of Biological Databases and Curation
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure-function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic promiscuity. ProtMiscuity co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8964a33c079d477b2823a0ffae3249
http://europepmc.org/articles/PMC6813136

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Cardiotoxicidad del estado de tolerancia a la glucosa alterada

Autor: Leandro Matías Sommese

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Introducción: La insuficiencia cardiaca y las arritmias ocurren con mayor frecuencia en pacientes con diabetes tipo 2 (DM2) que en la población general. La DM2 está precedida por una condición prediabética marcada por especies de oxígeno reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe425859829f0148fa72f01bafbc4fd
https://doi.org/10.35537/10915/66305

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Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814

Autor: Julieta Palomeque, Gabriela Mazzocchi, Evangelia G. Kranias, Alicia Mattiazzi, D. Fainstein, Darlene G. Skapura, Xander H.T. Wehrens, Mark McCauley, P. N. González, Leandro Matías Sommese, Jorge A. Negroni, P. Contreras, M. N. Di Carlo, Juan Ignacio Felice, Elena C. Lascano, Carlos Alfredo Valverde

Publikováno v: The Journal of Physiology. 594:3005-3030

Key points Mice with Ca(2+) -calmodulin-dependent protein kinase (CaMKII) constitutive pseudo-phosphorylation of the ryanodine receptor RyR2 at Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum (SR) C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::746763441678051258a337b9ff0be179
https://doi.org/10.1113/jp271622

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Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate

Autor: Marcia A. Kaetzel, María Cecilia Castro, John R. Dedman, Mark E. Anderson, Omar Velez Rueda, Leandro Matías Sommese, Carlos Alfredo Valverde, P.G. Blanco, Alicia Mattiazzi, Julieta Palomeque

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species (ROS) and subclinical cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c97e768d4e332bf24fa509881cd1f7
https://doi.org/10.1016/j.ijcard.2015.09.022

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CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury

Autor: Leandro Matías Sommese, Alicia Mattiazzi, Margarita Ana Salas, Matilde Said, Gustavo Rinaldi, Haiyun Ling, Jonathan L. Respress, Julieta Palomeque, Mariano Nahuel Di Carlo, Darlene G. Skapura, Xander H.T. Wehrens, Ernesto A. Aiello, Verónica Celeste De Giusti, Carlos Alfredo Valverde, Joan Heller Brown

Publikováno v: Di Carlo, MN; Said, M; Ling, H; Valverde, CA; De Giusti, VC; Sommese, L; et al.(2014). CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology, 74, 274-283. doi: 10.1016/j.yjmcc.2014.06.004. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5gv9p662

Ca2+-calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). Moreover, inhibition of CaMKII-dependent phosphorylations at the sarcoplasmic reticulum (SR) prevents CaMKII-induced I/R damage. However, the downstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b0ef97975269c4c50b5ccf322e0fae
http://www.sciencedirect.com/science/article/pii/S0022282814001989

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