Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Autor: Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163312 (2016)

Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the present study, we used a qua

Externí odkaz: https://doaj.org/article/963777c8a9844402ae8af96bb042329c

Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.

Autor: Sayani Dasgupta, Leandro M Castro, Russell Dulman, Ciyu Yang, Marion Schmidt, Emer S Ferro, Lloyd D Fricker

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e103604 (2014)

The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracell

Externí odkaz: https://doaj.org/article/a25220dad1ee422eb2cbd282a3f07f1c

The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization.

Autor: Alberto Malvezzi, Patrícia M Higa, Antonia T-do Amaral, Gustavo M Silva, Fabio C Gozzo, Emer S Ferro, Leandro M Castro, Leandro de Rezende, Gisele Monteiro, Marilene Demasi

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39408 (2012)

Thimet oligopeptidase (EP24.15) is a cysteine-rich metallopeptidase containing fifteen Cys residues and no intra-protein disulfide bonds. Previous work on this enzyme revealed that the oxidative oligomerization of EP24.15 is triggered by S-glutathiol

Externí odkaz: https://doaj.org/article/d1eb6ac02a524b949c397368b1d21451

Peptide Profile of Zebrafish Brain in a 6-OHDA-Induced Parkinson Model

Autor: Leandro M. Castro, Claudia Neves Correa, Louise Oliveira Fiametti

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2021-06-25T10:24:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Parkinson's disease (PD) is a chronic neurodegenerative disorder mainly attributed to the progressive loss of dopaminergic neurons in the sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab5a612ca9af5b720405ad43447565f
https://pubmed.ncbi.nlm.nih.gov/33570475

The Relevance of Thimet Oligopeptidase in the Regulation of Energy Metabolism and Diet-Induced Obesity

Autor: Mayara C. F. Gewehr, Maria Luiza Morais Barreto-Chaves, Eliana Hiromi Akamine, Bruna A.C. Santos, Nilton Barreto dos Santos, Niels Olsen Saraiva Camara, Aline C Inada, Angela Castoldi, Emer S. Ferro, Joanna Darck Carola Correia Lima, Amanda M Cordibello, Fabio C. Gozzo, Leandro M. Castro, Alexandre Abilio de Souza Teixeira, Marilia Seelaender, Camila Squarzoni Dale, José Cesar Rosa Neto, Nathalia Senger, Luana A Biondo, Renée de Nazaré Oliveira da Silva, Alice Cristina Rodrigues, Patrícia Reckziegel, Rosangela Aparecida dos Santos Eichler

Publikováno v: Biomolecules
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Volume 10
Issue 2
Biomolecules, Vol 10, Iss 2, p 321 (2020)

Thimet oligopeptidase (EC 3.4.24.15
EP24.15
THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides. The structural conformation of THOP1 provides a unique restriction re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec1050ea9a1cc8b2dbad0a013afc366
https://pubmed.ncbi.nlm.nih.gov/32079362