Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Leandro F. Vendruscolo"'
Autor:
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in
Externí odkaz:
https://doaj.org/article/69dd93baf3cc42269d69f72c7d7939c7
Autor:
Nicolaus Bruns VI, Elizabeth H. Tressler, Leandro F. Vendruscolo, Lorenzo Leggio, Mehdi Farokhnia
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107312- (2024)
Addiction is a chronic relapsing disease with high morbidity and mortality. Treatments for addiction include pharmacological and psychosocial interventions; however, currently available medications are limited in number and efficacy. The glucagon-lik
Externí odkaz:
https://doaj.org/article/c8ec867a59c6447e82d297495e6b447f
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation. Previous studies ha
Externí odkaz:
https://doaj.org/article/701cc92048b7402f9d741a2996a9b2b5
Publikováno v:
Nutrients, Vol 16, Iss 10, p 1527 (2024)
In the process of validating the elevated zero maze, a common test of anxiety-like behavior, in our laboratory, we demonstrated an anxiolytic-like effect of castor oil and its primary component, ricinoleic acid. We tested the effects of vehicle and c
Externí odkaz:
https://doaj.org/article/5770b18d2d47491689f97c1c00562018
Autor:
Khalin E. Nisbett, Luis A. Gonzalez, Marina Teruel, C. Sue Carter, Leandro F. Vendruscolo, Michael E. Ragozzino, George F. Koob
Publikováno v:
Neurobiology of Stress, Vol 26, Iss , Pp 100567- (2023)
Anxiety and depression are highly prevalent psychiatric disorders, affecting approximately 18% of the United States population. Evidence indicates that central oxytocin mediates social cognition, social bonding, and social anxiety. Although it is wel
Externí odkaz:
https://doaj.org/article/dfd79140c19d49c498fa80d4761e2de2
Autor:
Vicky Chuong, Mehdi Farokhnia, Sophia Khom, Claire L. Pince, Sophie K. Elvig, Roman Vlkolinsky, Renata C.N. Marchette, George F. Koob, Marisa Roberto, Leandro F. Vendruscolo, Lorenzo Leggio
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD). Here, we examined the effects of semag
Externí odkaz:
https://doaj.org/article/765809f41835482da1b03fd08c62a8c7
Publikováno v:
Addiction Neuroscience, Vol 5, Iss , Pp 100057- (2023)
Rodent models are useful for understanding the mechanisms that underlie opioid addiction, but most preclinical studies have focused on rewarding and consummatory aspects of opioids without components of dependence-induced escalation of drug taking or
Externí odkaz:
https://doaj.org/article/b213fa7d64a345e39ea41f6d751be200
Autor:
Gabriel M. Aldridge, Tyler A. Zarin, Adam J. Brandner, Olivier George, Nicholas W. Gilpin, Vez Repunte-Canonigo, Pietro Paolo Sanna, George F. Koob, Leandro F. Vendruscolo, Brooke E. Schmeichel
Publikováno v:
Addiction Neuroscience, Vol 3, Iss , Pp 100028- (2022)
Hypocretin/orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of signaling at hypocretin-receptor 1 (HCRT-R1) and hypocretin-receptor 2 (HCRT-R2) to compulsive alc
Externí odkaz:
https://doaj.org/article/0102601559f9496a88821ff6621d586a
Autor:
Kabirullah Lutfy, Lucia Hipolito, Valentina Ferretti, Leandro F. Vendruscolo, Marsida Kallupi
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Externí odkaz:
https://doaj.org/article/5625980a37b54562b35761d22579b257
Autor:
Marissa R. Jones, Adam J. Brandner, Leandro F. Vendruscolo, Janaina C. M. Vendruscolo, George F. Koob, Brooke E. Schmeichel
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The prevalence of sleep disruptions is higher among people with alcohol use disorder (AUD), particularly during alcohol withdrawal, compared to non-AUD individuals. Although women generally have a higher risk of developing sleep disorders, few studie
Externí odkaz:
https://doaj.org/article/87f2869988f9458d9b140faa5a8ea8bb