Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Leandro B. Bernardo"'
1
Akademický článek
Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
Autor: Daniel A. S. Kitagawa, Rafael B. Rodrigues, Thiago N. Silva, Wellington V. dos Santos, Vinicius C. V. da Rocha, Joyce S. F. D. de Almeida, Leandro B. Bernardo, Taynara Carvalho-Silva, Cintia N. Ferreira, Angelo A. T. da Silva, Alessandro B. C. Simas, Eugenie Nepovimova, Kamil Kuča, Tanos C. C. França, Samir F. de A. Cavalcante
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)
Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro
Externí odkaz: https://doaj.org/article/64caf545eedf4c7299e2546a21467177
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2
Akademický článek
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
Autor: Daniel A. S. Kitagawa, Samir F. de A. Cavalcante, Reuel L. de Paula, Rafael B. Rodrigues, Leandro B. Bernardo, Munique C. J. da Silva, Thiago N. da Silva, Wellington V. dos Santos, José M. Granjeiro, Joyce S. F. D. de Almeida, Marcos C. Barcellos, Ana Beatriz de A. Correa, Tanos C. C. França, Kamil Kuča, Alessandro B. C. Simas
Publikováno v: Biomolecules, Vol 9, Iss 10, p 583 (2019)
Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents. Pyridinium oxime
Externí odkaz: https://doaj.org/article/04b576b9b7084a1d8cfbf4f2aca184c0
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4
Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators
Autor: Tanos C. C. França, Angelo A.T. da Silva, Leandro B. Bernardo, Eugenie Nepovimova, Vinicius C V da Rocha, Taynara Carvalho-Silva, Thiago H. Silva, Cintia N. Ferreira, Joyce S. F. D. de Almeida, Wellington V Dos Santos, Rafael B. Rodrigues, Samir F. de A. Cavalcante, Kamil Kuca, Daniel A. S. Kitagawa, Alessandro B. C. Simas
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)
Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d48cd3065be20ef284226717b5ba8
https://doi.org/10.1080/14756366.2021.1916009
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5
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon
Autor: José Mauro Granjeiro, Alessandro B. C. Simas, Ana Beatriz de A. Correa, Joyce S. F. D. de Almeida, Munique C J da Silva, Daniel A. S. Kitagawa, Thiago N. da Silva, Rafael B. Rodrigues, Reuel L. de Paula, Tanos C. C. França, Wellington V Dos Santos, Kamil Kuca, Samir F. de A. Cavalcante, Marcos C Barcellos, Leandro B. Bernardo
Publikováno v: Biomolecules, Vol 9, Iss 10, p 583 (2019)
Biomolecules
Volume 9
Issue 10
Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents. Pyridinium oxime
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90802c58da67856667153b8b2de11845
https://www.mdpi.com/2218-273X/9/10/583
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6
One-Pot Synthesis of NEMP, a VX Surrogate, and Reactivation of NEMP-Inhibited Electrophorus Eel Acetylcholinesterase by Current Antidotes
Autor: Samir F. de A. Cavalcante, Daniel A. S. Kitagawa, Taynara C. Silva, Alessandro B. C. Simas, Ana Beatriz de A. Correa, Leandro B. Bernardo, Rafael B. Rodrigues
Publikováno v: Journal of the Brazilian Chemical Society.
The use of nerve agents, organophosphorus compounds which irreversibly inhibit acetylcholinesterase, in conflicts and terrorism has gained renewed geopolitical status in recent years. As no “universal antidote” has ever been produced, the develop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a9b5078fb04a6de34bd7ee2f90401b
https://doi.org/10.21577/0103-5053.20180246
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7
Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate
Autor: Joyce S. F. D. de Almeida, Ana Beatriz de A. Correa, Alessandro B. C. Simas, Wellington V Dos Santos, Samir F. de A. Cavalcante, Thiago N. da Silva, Leandro B. Bernardo, Tanos C. C. França, Rafael B. Rodrigues, Kamil Kuca, Daniel A. S. Kitagawa
Publikováno v: Chemico-Biological Interactions. 309:108682
Casualties caused by nerve agents, potent acetylcholinesterase inhibitors, have attracted attention from media recently. Poisoning with these chemicals may be fatal if not correctly addressed. Therefore, research on novel antidotes is clearly warrant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d768331c82a5d43b8db467912c1a7d40
https://doi.org/10.1016/j.cbi.2019.05.048
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