Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leandro Augusto, Barbosa"'
Autor:
Davi Azevedo Ferreira, Anna Beatriz Araujo Medeiros, Mariana Mendonça Soares, Éssia de Almeida Lima, Gabriela Carolina Santos Lima de Oliveira, Mateus Bernardo da Silva Leite, Matheus Vieira Machado, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Cristoforo Scavone, Marcelo Tigre Moura, Sandra Rodrigues-Mascarenhas
Publikováno v:
Cells, Vol 13, Iss 18, p 1568 (2024)
Cardiotonic steroids are known to bind to Na+/K+-ATPase and regulate several biological processes, including the immune response. The synthetic cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) is emerging as a promising immunomodulatory molecule,
Externí odkaz:
https://doaj.org/article/a7ce4a90f6704e5d80aadee548dacc03
Autor:
Anderson Dutra de Melo, Victor Antonio Ferreira Freire, Ítalo Leonardo Diogo, Hérica de Lima Santos, Leandro Augusto Barbosa, Luciana Estefani Drumond de Carvalho
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1397 (2023)
Epilepsy is a neurological disorder characterized by epileptic seizures resulting from neuronal hyperexcitability, which may be related to failures in Na,K-ATPase activity and oxidative stress participation. We conducted this study to investigate the
Externí odkaz:
https://doaj.org/article/f2a111fb68d54929b69ddb2a5dbf13a3
Autor:
Israel José Pereira Garcia, Paula Fernanda Kinoshita, Jéssica Martins de Moura Valadares, Luciana Estefani Drumond de Carvalho, Vanessa Faria Cortes, Leandro Augusto Barbosa, Cristoforo Scavone, Hérica de Lima Santos
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 920 (2023)
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na,K-ATPase, causing the modulation of intracellular signalling pathways in the Central N
Externí odkaz:
https://doaj.org/article/830e2b758a314e83ba24b3a93d10576c
Autor:
Daniel Clemente de Moraes, Ana Claudia Tessis, Rodrigo Rollin-Pinheiro, Jefferson Luiz Princival, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Eliana Barreto-Bergter, Antônio Ferreira-Pereira
Publikováno v:
Journal of Fungi, Vol 8, Iss 8, p 769 (2022)
The poor outcome of treatments for fungal infections is a consequence of the increasing incidence of resistance to antifungal agents, mainly due to the overexpression of efflux pumps. To surpass this mechanism of resistance, a substance able to inhib
Externí odkaz:
https://doaj.org/article/6f060bf6f0814a088ce9bb882cf7cab6
Autor:
Israel José Pereira Garcia, Jessica Silva Cézar, Bruno Silva Lemos, Lilian Nayra Silva, Rosy Iara Maciel de Azambuja Ribeiro, Camilla Camerino Santana, Luciano Aparecido Meireles Grillo, Flavia Carmo Horta Pinto, Samyra Lopes Buzelle, Vanessa Faria Cortes, Hérica de Lima Santos, Maria Emilia Soares Martins dos Santos, Leandro Augusto Barbosa
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018)
ABSTRACT It is widely known that high fat diet (HFD) can contribute to the advent of health problems. Recent studies have indicated that obesity imposes a hemodynamic overload to the kidneys. In order to further investigate such injuries, two groups
Externí odkaz:
https://doaj.org/article/2feccd9ea0d74357a0c1ae111b071106
Autor:
Israel José Pereira Garcia, Paula Fernanda Kinoshita, Jéssica Martins de Moura Valadares, Luciana Estefani Drumond de Carvalho, Vanessa Faria Cortes, Leandro Augusto Barbosa, Cristoforo Scavone, Hérica de Lima Santos
Publikováno v:
Biomedicines; Volume 11; Issue 3; Pages: 920
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na, K-ATPase, causing the modulation of intracellular signalling pathways in the central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b42eded1ced12b649ab59bb52fd096
https://doi.org/10.21203/rs.3.rs-2135374/v1
https://doi.org/10.21203/rs.3.rs-2135374/v1
Publikováno v:
Cadernos de Saúde Pública, Vol 25, Iss 9, Pp 1875-1882 (2009)
O câncer vem se destacando entre as doenças crônicas, sendo a segunda causa de morte em países desenvolvidos. Os cuidados paliativos se propõem a oferecer cuidados de suporte global, visando ao controle de sintomas e à melhora da qualidade de v
Externí odkaz:
https://doaj.org/article/757370aabee24162a57925f11904b7fb
Autor:
Jéssica Martins de Moura, Valadares, Sumit O, Bajaj, Hongyan, Li, Hua-Yu L, Wang, Simone Cavalcante, Silva, Israel José Pereira, Garcia, Duane Gischewiski, Pereira, Pedro, Azalim, Luis Eduardo Menezes, Quintas, François, Noël, Vanessa Faria, Cortes, George Augustine, O'Doherty, Leandro Augusto, Barbosa
Publikováno v:
J Cell Biochem
Cardiac glycosides, such as digoxin and digitoxin, are compounds that interact with Na(+)/K(+)-ATPase to induce anti-neoplastic effects; however, these cardiac glycosides have narrow therapeutic index. Thus, semi-synthetic analogs of digitoxin with m
Autor:
Gisele Capanema, de Oliveira, Sayonarah Carvalho, Rocha, Miliane Alves, da Silva Lopes, Natasha, Paixão, Silmara Lúcia Grego, Alves, Marco Túlio Corrêa, Pessoa, François, Noël, Luis Eduardo M, Quintas, Leandro Augusto, Barbosa, José Augusto Ferreira Perez, Villar, Vanessa Faria, Cortes
Publikováno v:
The Journal of membrane biology. 254(5-6)
Na,K-ATPase (NKA) and cardiotonic steroids (CTS) have shown potent cytotoxic and anticancer effects. Here, we have synthesized a series of CTS digoxin derivatives (γ-benzylidene) with substitutions in the lactone ring and evaluated the cytotoxicity
Autor:
Izabella Thaís, Silva, Jennifer, Munkert, Elke, Nolte, Naira Fernanda Zanchett, Schneider, Sayonarah Carvalho, Rocha, Ana Carolina Pacheco, Ramos, Wolfgang, Kreis, Fernão Castro, Braga, Rodrigo Maia, de Pádua, Alex G, Taranto, Vanessa, Cortes, Leandro Augusto, Barbosa, Sven, Wach, Helge, Taubert, Cláudia Maria Oliveira, Simões
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 107
Cardiac glycosides (CGs) are natural compounds used to treat congestive heart failure. They have garnered attention as a potential cancer treatment option, especially because they bind to Na