Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Leandro A A, Avelar"'
Autor:
Haley S. Ball, Misgina Girma, Mosufa Zainab, Honoria Riley, Christoph T. Behrendt, Claudia Lienau, Sarah Konzuch, Leandro A. A. Avelar, Beate Lungerich, Iswarduth Soojhawon, Schroeder M. Noble, Thomas Kurz, Robin D. Couch
Publikováno v:
ACS Omega, Vol 5, Iss 10, Pp 5170-5175 (2020)
Externí odkaz:
https://doaj.org/article/b4ecf7ff53064ab1aa64dc4e6aca1747
Autor:
Talea Knak, Mona A. Abdullaziz, Stefan Höfmann, Leandro A. Alves Avelar, Saskia Klein, Matthew Martin, Markus Fischer, Nobutada Tanaka, Thomas Kurz
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1553 (2022)
To address the continued rise of multi-drug-resistant microorganisms, the development of novel drugs with new modes of action is urgently required. While humans biosynthesize the essential isoprenoid precursors isopentenyl diphosphate (IPP) and dimet
Externí odkaz:
https://doaj.org/article/6b337041a5eb46fba37c191faecc4642
Autor:
Daniel Nettersheim, Margaretha A. Skowron, Thomas Kurz, Peter Albers, Karl Köhrer, Patrick Petzsch, Felix Bremmer, Guenter Niegisch, Michèle J. Hoffmann, Hector Torres-Gomez, Fabian Fischer, Stefan Höfmann, Andrea Seiwert, Melanie R. Müller, Leandro A. Alves Avelar, Alexa Stephan, Aaron Burmeister
Supplementary Data from Establishment and Evaluation of Dual HDAC/BET Inhibitors as Therapeutic Options for Germ Cell Tumors and Other Urological Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40632b90c660eb71fd7e0bac540e3f4f
https://doi.org/10.1158/1535-7163.22523815
https://doi.org/10.1158/1535-7163.22523815
Autor:
Ki-Back Chu, Hae-Ahm Lee, Marc Pflieger, Fabian Fischer, Yodita Asfaha, Leandro A. Alves Avelar, Alexander Skerhut, Matthias U. Kassack, Finn K Hansen, Andrea Schöler, Thomas Kurz, Min-Jeong Kim, Eun-Kyung Moon, Fu-Shi Quan
Publikováno v:
ACS Infectious Diseases. 8:271-279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd641bde42b0c7c81cc719b092c1afc
https://doi.org/10.1021/acsinfecdis.1c00390
https://doi.org/10.1021/acsinfecdis.1c00390
Publikováno v:
Future Medicinal Chemistry. 14:143-166
Proteolysis-targeting chimeras (PROTACs) are a powerful tool to hijack the endogenous ubiquitin-proteasome system (UPS) and to degrade the intracellular proteins of therapeutic importance. Recently, two heterobifunctional degraders targeting hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cfc067fd78632154575947cb3733a4
https://doi.org/10.4155/fmc-2021-0206
https://doi.org/10.4155/fmc-2021-0206
Autor:
Aaron Burmeister, Alexa Stephan, Leandro A. Alves Avelar, Melanie R. Müller, Andrea Seiwert, Stefan Höfmann, Fabian Fischer, Hector Torres-Gomez, Michèle J. Hoffmann, Guenter Niegisch, Felix Bremmer, Patrick Petzsch, Karl Köhrer, Peter Albers, Thomas Kurz, Margaretha A. Skowron, Daniel Nettersheim
Publikováno v:
Molecular cancer therapeutics. 21(11)
Urological malignancies represent major challenges for clinicians, with annually rising incidences. In addition, cisplatin treatment induced long-term toxicities and the development of therapy resistance emphasize the need for novel therapeutics. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9619055c43bc194a622e0bb879c82c49
https://pubmed.ncbi.nlm.nih.gov/35999659
https://pubmed.ncbi.nlm.nih.gov/35999659
Autor:
Matthias U. Kassack, Leandro A. Alves-Avelar, Thomas Kurz, Stefan Klinken, Beate Lungerich, Nadine Horstick-Muche, Yodita Asfaha, Alexander Jan Skerhut
Publikováno v:
Arkivoc. 2020:228-241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc644a3daf8386d3051d61658af4878
https://doi.org/10.24820/ark.5550190.p011.279
https://doi.org/10.24820/ark.5550190.p011.279
Autor:
Beate Lungerich, Claudia Lienau, Haley Ball, Leandro A. Alves Avelar, Christoph T. Behrendt, Mosufa Zainab, Misgina Girma, Iswarduth Soojhawon, Thomas Kurz, Sarah Konzuch, Schroeder M. Noble, Honoria Riley, Robin D. Couch
Publikováno v:
ACS Omega, Vol 5, Iss 10, Pp 5170-5175 (2020)
Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis. The MEP pathway ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37bda474224e06d850a442e27803d2bd
https://doi.org/10.1021/acsomega.9b04171
https://doi.org/10.1021/acsomega.9b04171
Autor:
Leandro A A Avelar, Cristian D Camilo, Sérgio de Albuquerque, William B Fernandes, Cristiana Gonçalez, Peter W Kenny, Andrei Leitão, James H McKerrow, Carlos A Montanari, Erika V Meñaca Orozco, Jean F R Ribeiro, Josmar R Rocha, Fabiana Rosini, Marta E Saidel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003916 (2015)
A series of compounds based on the dipeptidyl nitrile scaffold were synthesized and assayed for their inhibitory activity against the T. cruzi cysteine protease cruzain. Structure activity relationships (SARs) were established using three, eleven and
Externí odkaz:
https://doaj.org/article/c07c0749619b40c0b5dab804ecd2bd13
Autor:
Michael Leven, Vicky M. Avery, Stephan Meister, Jana Held, Michael J. Delves, Sandra Duffy, Krystina Kuna, Elizabeth A. Winzeler, Benjamin Mordmüller, Thomas Kurz, Leandro A. Alves Avelar, Serena Tschan, David Plouffe
Publikováno v:
ChemMedChem. 14:501-511
A series of novel 8-aminoquinolines (8-AQs) with an aminoxyalkyl side chain were synthesized and evaluated for in vitro antiplasmodial properties against asexual blood stages, liver stages, and sexual stages of Plasmodium falciparum. 8-AQs bearing 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78defdef19417f9bc4af603611451eb1
https://doi.org/10.1002/cmdc.201800691
https://doi.org/10.1002/cmdc.201800691