Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Leandro M. Castro"'
Autor:
Ivan Nunes, Carla S Guimarães, Pedro Henrique A G Moura, Mariana Pedrozo, Matheus de Toledo Moroti, Leandro M Castro, Daniel R Stuginski, Edelcio Muscat
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0244812 (2021)
Species of Brachycephalus has been having taxonomical issues due its morphological similarity and genetic conservatism. Herein, we describe a new species of Brachycephalus from the south Mantiqueira mountain range and semidecidual forests in the muni
Externí odkaz:
https://doaj.org/article/f77a130c0f3644f9abe93d1b8087e8b2
Autor:
Mayara C. F. Gewehr, Alexandre A. S. Teixeira, Bruna A. C. Santos, Luana A. Biondo, Fábio C. Gozzo, Amanda M. Cordibello, Rosangela A. S. Eichler, Patrícia Reckziegel, Renée N. O. Da Silva, Nilton B. Dos Santos, Niels O. S. Camara, Angela Castoldi, Maria L. M. Barreto-Chaves, Camila S. Dale, Nathalia Senger, Joanna D. C. C. Lima, Marilia C. L. Seelaender, Aline C. Inada, Eliana H. Akamine, Leandro M. Castro, Alice C. Rodrigues, José C. Rosa Neto, Emer S. Ferro
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 321 (2020)
Thimet oligopeptidase (EC 3.4.24.15; EP24.15; THOP1) is a potential therapeutic target, as it plays key biological functions in processing biologically functional peptides. The structural conformation of THOP1 provides a unique restriction regarding
Externí odkaz:
https://doaj.org/article/cd23c3a4fd914795937480a86869742c
Publikováno v:
EuPA Open Proteomics, Vol 3, Iss C, Pp 143-151 (2014)
Peptidomics techniques have identified hundreds of peptides that are derived from proteins present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular peptides to distinguish them from secretory pathway peptides that f
Externí odkaz:
https://doaj.org/article/2f0ca4d1a63e4c1591e8e9d4fc03fdd9
Autor:
Nilton B. dos Santos, Roseane D. Franco, Rosana Camarini, Carolina D. Munhoz, Rosangela A. S. Eichler, Mayara C. F. Gewehr, Patricia Reckziegel, Ricardo P. Llanos, Camila S. Dale, Victoria R. O. da Silva, Vanessa F. Borges, Braulio H. F. Lima, Fernando Q. Cunha, Bruna Visniauskas, Jair R. Chagas, Sergio Tufik, Fernanda F. Peres, Vanessa C. Abilio, Jorge C. Florio, Leo K. Iwai, Vanessa Rioli, Benedito C. Presoto, Alessander O. Guimaraes, Joao B. Pesquero, Michael Bader, Leandro M. Castro, Emer S. Ferro
Publikováno v:
Biomolecules, Vol 9, Iss 8, p 382 (2019)
Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1−/−) is described showing that they are viable, h
Externí odkaz:
https://doaj.org/article/fee5d888dd5846aa93227678225a6f5a
Autor:
Sayani Dasgupta, Michael A. Fishman, Leandro M. Castro, Alexandre K. Tashima, Emer S. Ferro, Lloyd D. Fricker
Publikováno v:
Biomolecules, Vol 9, Iss 6, p 207 (2019)
Peptides produced by the proteasome have been proposed to function as signaling molecules that regulate a number of biological processes. In the current study, we used quantitative peptidomics to test whether conditions that affect protein stability,
Externí odkaz:
https://doaj.org/article/75755021502b45f9951f927b5f3f3d80
Autor:
Sayani Dasgupta, Ciyu Yang, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Robyn D Moir, Ian M Willis, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163312 (2016)
Peptides function as signaling molecules in species as diverse as humans and yeast. Mass spectrometry-based peptidomics techniques provide a relatively unbiased method to assess the peptidome of biological samples. In the present study, we used a qua
Externí odkaz:
https://doaj.org/article/963777c8a9844402ae8af96bb042329c
Autor:
Leandro M. Castro, Claudia Neves Correa, Louise Oliveira Fiametti, Maria Eduarda Mazzi Esquinca
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-28T19:48:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Peptidomics can be defined as the qualitative and quantitative analysis of
Autor:
Sayani Dasgupta, Michael A Fishman, Hana Mahallati, Leandro M Castro, Alexandre K Tashima, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145333 (2015)
Huntington's disease is the result of a long polyglutamine tract in the gene encoding huntingtin protein, which in turn causes a large number of cellular changes and ultimately results in neurodegeneration of striatal neurons. Although many theories
Externí odkaz:
https://doaj.org/article/485f4f8a08234278ba9c7ce9dbb9178d
Autor:
Sayani Dasgupta, Leandro M Castro, Russell Dulman, Ciyu Yang, Marion Schmidt, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103604 (2014)
The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracell
Externí odkaz:
https://doaj.org/article/a25220dad1ee422eb2cbd282a3f07f1c
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2021-06-25T10:24:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01 Parkinson's disease (PD) is a chronic neurodegenerative disorder mainly attributed to the progressive loss of dopaminergic neurons in the sub