Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Leander Van Neste"'
Autor:
Tim C. de Ruijter, Kim M. Smits, Maureen J. Aarts, Irene E. G. van Hellemond, Leander Van Neste, Bart de Vries, Petronella G. M. Peer, Jürgen Veeck, Manon van Engeland, Vivianne C. G. Tjan-Heijnen
Publikováno v:
Diagnostic and Prognostic Research, Vol 3, Iss 1, Pp 1-8 (2019)
Abstract Background The effect of extended adjuvant aromatase inhibition in hormone-positive breast cancer after sequential tamoxifen, aromatase inhibitor treatment of 5 years was recently investigated by the DATA study. This study found no statistic
Externí odkaz:
https://doaj.org/article/f6e07aacda75400586e399d84923b11c
Autor:
Leander Van Neste, Kirk J. Wojno, Ricardo Henao, Shrikant Mane, Howard Korman, Jason Hafron, Kenneth Kernen, Rima Tinawi-Aljundi, Mathew Putzi, Amin I. Kassis, Philip W. Kantoff
Publikováno v:
Cells, Vol 10, Iss 10, p 2567 (2021)
The primary objective of this study is to detect biomarkers and develop models that enable the identification of clinically significant prostate cancer and to understand the biologic implications of the genes involved. Peripheral blood samples (1018
Externí odkaz:
https://doaj.org/article/5a1827c9a5934f58ae6864cae3e91697
Autor:
Daphne Hessels, Hans de Jong, Sander A. Jannink, Michael Carter, Manuel Krispin, Wim Van Criekinge, Leander Van Neste, Jack A. Schalken
Publikováno v:
Translational Medicine Communications, Vol 2, Iss 1, Pp 1-12 (2017)
Abstract Background The challenge for prostate cancer (PCa) diagnosis is to improve the ability to distinguish indolent from aggressive PCa. Increased urinary levels of Distal-less Homeobox 1 (DLX1) and Homeobox C6 (HOXC6) mRNA have been associated w
Externí odkaz:
https://doaj.org/article/a3d03fa6fdb9485fb2cb80ff68ee4107
Autor:
Kornel E Schuebel, Wei Chen, Leslie Cope, Sabine C Glöckner, Hiromu Suzuki, Joo-Mi Yi, Timothy A Chan, Leander Van Neste, Wim Van Criekinge, Sandra van den Bosch, Manon van Engeland, Angela H Ting, Kamwing Jair, Wayne Yu, Minoru Toyota, Kohzoh Imai, Nita Ahuja, James G Herman, Stephen B Baylin
Publikováno v:
PLoS Genetics, Vol 3, Iss 9, Pp 1709-1723 (2007)
We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a pan
Externí odkaz:
https://doaj.org/article/255e50ac950f447a90f132b7d3c8660a
Autor:
Ilse Van der Auwera, Wayne Yu, Liping Suo, Leander Van Neste, Peter van Dam, Eric A Van Marck, Patrick Pauwels, Peter B Vermeulen, Luc Y Dirix, Steven J Van Laere
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12616 (2010)
BACKGROUND: Abnormal DNA methylation is well established for breast cancer and contributes to its progression by silencing tumor suppressor genes. DNA methylation profiling platforms might provide an alternative approach to expression microarrays for
Externí odkaz:
https://doaj.org/article/21d7aaff20a44ac4a0cb9c6e2d26edd9
Autor:
Timothy A Chan, Sabine Glockner, Joo Mi Yi, Wei Chen, Leander Van Neste, Leslie Cope, James G Herman, Victor Velculescu, Kornel E Schuebel, Nita Ahuja, Stephen B Baylin
Publikováno v:
PLoS Medicine, Vol 5, Iss 5, p e114 (2008)
The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressor
Externí odkaz:
https://doaj.org/article/2719a47e3b454596ba7ff3156efbf729
Autor:
Kim De Keersmaecker, Idoya Lahortiga, Nicole Mentens, Cedric Folens, Leander Van Neste, Sofie Bekaert, Peter Vandenberghe, Maria D. Odero, Peter Marynen, Jan Cools
Publikováno v:
Haematologica, Vol 93, Iss 4 (2008)
Background Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with γ-secretase inhibitors causes cell cycle block, but only after treatment for several days. We further documented the effect
Externí odkaz:
https://doaj.org/article/39823d40c1414292b05a844cedcf4544
Autor:
Manon van Engeland, Nita Ahuja, Gerrit A. Meijer, Wim van Criekinge, Stephen B. Baylin, James G. Herman, Kornel E. Schuebel, Joost Louwagie, Kim A.D. Wouters, Hanneke E.C. Niessen, Leander Van Neste, Kim M. Smits, Marjolein H.F.M. Lentjes, Joo Mi Yi, Veerle Melotte
Supplementary Figure 1. Study population test and training set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a962282e14748219f11c622cb955f4
https://doi.org/10.1158/1940-6207.22524861
https://doi.org/10.1158/1940-6207.22524861
Autor:
Manon van Engeland, Nita Ahuja, Gerrit A. Meijer, Wim van Criekinge, Stephen B. Baylin, James G. Herman, Kornel E. Schuebel, Joost Louwagie, Kim A.D. Wouters, Hanneke E.C. Niessen, Leander Van Neste, Kim M. Smits, Marjolein H.F.M. Lentjes, Joo Mi Yi, Veerle Melotte
Supplementary Table 1. Patient characteristics of training and test studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14193941ddeec427044bf07aa9230cfb
https://doi.org/10.1158/1940-6207.22524858
https://doi.org/10.1158/1940-6207.22524858
Autor:
Manon van Engeland, Nita Ahuja, Gerrit A. Meijer, Wim van Criekinge, Stephen B. Baylin, James G. Herman, Kornel E. Schuebel, Joost Louwagie, Kim A.D. Wouters, Hanneke E.C. Niessen, Leander Van Neste, Kim M. Smits, Marjolein H.F.M. Lentjes, Joo Mi Yi, Veerle Melotte
Supplementary Table 2. Primers and Beacons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf815055ae6194f58c00830aa483acb
https://doi.org/10.1158/1940-6207.22524855
https://doi.org/10.1158/1940-6207.22524855