Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leander Tryphonas"'
A Synopsis of the Third International Federation of Societies of Toxicologic Pathologists Conference
Publikováno v:
Toxicologic Pathology. 28:370-374
A primary goal of the Third International Federation of Societies of Toxicologic Pathologists Conference was to review current scientific and regulatory thought on dThresholds for Genotoxic Carcinogens,d dEndocrine Modulators in the Environment,d dMo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c558ecf47630fbbbadc0a2b8eeda4332
https://doi.org/10.1177/019262330002800303
https://doi.org/10.1177/019262330002800303
Autor:
Leander Tryphonas, John G. Clement
Publikováno v:
Toxicologic Pathology. 23:393-409
Although myocardial damage caused by soman has been previously reported, its relation to brain damage is unclear. In order to clarify this relationship, we examined the histomorphogenesis of central nervous system (CNS) and myocardial lesions in Spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5374a14ac10969ad3c9005694f8bde8
https://doi.org/10.1177/019262339502300316
https://doi.org/10.1177/019262339502300316
Publikováno v:
Toxicologic Pathology. 18:297-303
To study the CNS effects of domoic acid (D.A.), 6 adult Cynomolgus monkeys (M. fascicularis) were dosed intraperitoneally (4 mg/kg) or intravenously (0.025-0.5 mg/kg) with D.A. obtained from cultured mussels contaminated with this neurotoxin. Clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4101348a0a6f2f19cf9c3411ec3026
https://doi.org/10.1177/019262339001800208
https://doi.org/10.1177/019262339001800208
Publikováno v:
Food and Chemical Toxicology. 28:707-715
A recent outbreak of marine food poisoning in humans was attributed to the consumption of blue mussels (Mytilus edulis L.) contaminated with domoic acid (DA) that was produced by the diatom Nitzchia pungens. The clinical and morphological effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8d7322a5cab4083b8031ac6abeb58c7
https://doi.org/10.1016/0278-6915(90)90147-f
https://doi.org/10.1016/0278-6915(90)90147-f
Publikováno v:
Toxicologic Pathology. 21:102-104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96df644d15e351d21b6892e0844501e4
https://doi.org/10.1177/019262339302100114
https://doi.org/10.1177/019262339302100114
Autor:
Leander Tryphonas, Jean Bedard, Martin Lis, John H. Huffman, Robert W. Sidwell, John C. Drach, Suzanne May, Robert R. Rando, Laval Chan, Terry L. Bowlin
Cidofovir is the first nucleoside monophosphate analogue currently being used for the treatment of human cytomegalovirus (HCMV) retinitis in individuals with AIDS. Unfortunately, the period of therapy with the use of this compound may be limited due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275c3210143fc3327a386db1128956d0
https://europepmc.org/articles/PMC89160/
https://europepmc.org/articles/PMC89160/
Publikováno v:
Toxicologic pathology. 24(2)
Male Sprague-Dawley rats were given atropine methylnitrate (20 mg/kg) and HI-6 (125 mg/kg) ip 10 min before a single injection of 130 μg soman/kg sc, and the heart was examined by light and electron microscopy 10, 25, 45, 90, and 180 min after the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4421dad08bfa20aef83a5bc6922abad2
https://pubmed.ncbi.nlm.nih.gov/8992609
https://pubmed.ncbi.nlm.nih.gov/8992609
Autor:
F. Iverson, Leander Tryphonas
Publikováno v:
Toxicologic pathology. 18(1 Pt 2)
A novel type of intoxication in Canada in 1987 was traced to consumption of cultivated mussels contaminated with the excitotoxin domoic acid. Studies carried out in rats and monkeys revealed that parenterally administered domoic acid induces in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c145ede9b62426bb559fdbc30f1672
https://pubmed.ncbi.nlm.nih.gov/2195636
https://pubmed.ncbi.nlm.nih.gov/2195636
Autor:
Jos Mes, Jim Wong, Leander Tryphonas, D.L. Arnold, Z.Z. Zawidzka, Helen Tryphonas, S.M. Charbonneau
Publikováno v:
Archives of Environmental Contamination and Toxicology. 15:159-169
Aroclor® 1254 (PCB), at a dose of 280 μg/kg body weight (equivalent to 200 μg/kg/day) was given 5 days per week to groups of cynomolgus and rhesus monkeys. Cynomolgus monkeys were treated for 12 to 13 months and rhesus monkeys for 27 to 28 months.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f945352b457124688d0384212e3bf7
https://doi.org/10.1007/bf01059965
https://doi.org/10.1007/bf01059965
Publikováno v:
Fundamental and Applied Toxicology. 5:251-264
The association between selected neuropathological lesions and effects on mitochondrial and nuclear DNA synthesis was explored in cats exposed in vivo to methylmercuric chloride. Two groups of eight adult female cats ingested 0 or 176 μg Hg/kg body
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe4ed1337937e4155f511b8731ecd3a
https://doi.org/10.1016/0272-0590(85)90073-9
https://doi.org/10.1016/0272-0590(85)90073-9