The Role of NETosis and Complement Activation in COVID-19-Associated Coagulopathies

Autor: Emily Parissa Ghanbari, Kai Jakobs, Marianna Puccini, Leander Reinshagen, Julian Friebel, Arash Haghikia, Nicolle Kränkel, Ulf Landmesser, Ursula Rauch-Kröhnert

Publikováno v: Biomedicines, Vol 11, Iss 5, p 1371 (2023)

Inflammation-induced coagulopathy is a common complication associated with coronavirus disease 2019 (COVID-19). We aim to evaluate the association of NETosis and complement markers with each other as well as their association with thrombogenicity and

Externí odkaz: https://doaj.org/article/440fcb475f094b16b0292c9d40f839e3

Cystic fibrosis transmembrane conductance regulator potentiators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Autor: Szandor Simmons, Erik Asmus, Weronika Karle, Markus Brack, Corey Wittig, Felix Behrens, Leander Reinshagen, Lasti Erfinanda, Laura Michalick, Patrick Smeele, Charissa van den Brom, Toralf Kaiser, Leif Sander, Ulf Landmesser, Arash Haghikia, Robert Preissner, Harm Bogaard, Martin Witzenrath, Wolfgang Kuebler, Robert Szulcek

Publikováno v: Physiology. 38

Cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel and ABC transporter; its mutations cause the clinical picture of cystic fibrosis (CF). Of late, CFTR has emerged as an important regulator of platelet function, as CFTR dysfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16d4914415fbe352a765d0ab2f9fab8d
https://doi.org/10.1152/physiol.2023.38.s1.5729301

Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Autor: Erik Asmus, Weronika Karle, Markus C. Brack, Corey Wittig, Felix Behrens, Leander Reinshagen, Moritz Pfeiffer, Sabrina Schulz, Bertina Mandzimba-Maloko, Lasti Erfinanda, Paul L. Perret, Laura Michalick, Patrick J. Smeele, Endry H.T. Lim, Charissa E. van den Brom, Alexander B.A. Vonk, Toralf Kaiser, Norbert Suttorp, Stefan Hippenstiel, Leif E. Sander, Florian Kurth, Ursula Rauch, Ulf Landmesser, Arash Haghikia, Robert Preissner, Harm J. Bogaard, Martin Witzenrath, Wolfgang M. Kuebler, Robert Szulcek, Szandor Simmons

Publikováno v: Asmus, E, Karle, W, Brack, M C, Wittig, C, Behrens, F, Reinshagen, L, Pfeiffer, M, Schulz, S, Mandzimba-Maloko, B, Erfinanda, L, Perret, P L, Michalick, L, Smeele, P J, Lim, E H T, van den Brom, C E, Vonk, A B A, Kaiser, T, Suttorp, N, Hippenstiel, S, Sander, L E, Kurth, F, Rauch, U, Landmesser, U, Haghikia, A, Preissner, R, Bogaard, H J, Witzenrath, M, Kuebler, W M, Szulcek, R & Simmons, S 2023, ' Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients ', The European respiratory journal, vol. 61, no. 3, 2202009 . https://doi.org/10.1183/13993003.02009-2022
European respiratory journal, 61(3). European Respiratory Society
The European respiratory journal, 61(3):2202009. European Respiratory Society

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators reduce agonist-induced platelet activation and function. CFTR modulators, such as ivacaftor, present a promising therapeutic strategy in thrombocytopathies, including severe COVID-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d012e8c4eadda39018301e898b24c4
https://doi.org/10.1183/13993003.02009-2022