Výsledky vyhledávání - "Leala Aljehane"

CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis

Autor: Anirudh Gaur, Dean S. Rosenthal, Eric Glasgow, Leala Aljehane, Ryan Dougherty, Alexandra M Ferraro, Cynthia M. Simbulan-Rosenthal, Li-Wei Kuo, Sahar Vakili, Peter Sykora, Ryyan Alobaidi, Seema Agarwal

Publikováno v: Cancers, Vol 11, Iss 10, p 1490 (2019)
Cancers
Volume 11
Issue 10

CD133, known as prominin1, is a penta-span transmembrane glycoprotein presumably acancer stem cell marker for carcinomas, glioblastomas, and melanomas. We showed that CD133(+)&lsquo
melanoma-initiating cells&rsquo
are associated with chemor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555d4264b71424a2184aca55c466ec8c
https://www.mdpi.com/2072-6694/11/10/1490

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CD133 Is Associated with Increased Melanoma Cell Survival after Multikinase Inhibition

Autor: Sahar Vakili, Cynthia M. Simbulan-Rosenthal, Anirudh Gaur, Leala Aljehane, Qing Qin, Maryam AbdusSamad, Kumari Karna, Dean S. Rosenthal, Ryan Dougherty, Li-Wei Kuo, Havens Clark, Edward C. McCarron, Hengbo Zhou

Publikováno v: Journal of Oncology, Vol 2019 (2019)
Journal of Oncology

FDA-approved kinase inhibitors are now used for melanoma, including combinations of the MEK inhibitor trametinib, and BRAF inhibitor dabrafenib for BRAFV600 mutations. NRAS-mutated cell lines are also sensitive to MEK inhibitionin vitro, and NRAS-mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba3cc85454464d78f1d72a85bdec42
https://doaj.org/article/4bc1a2ea927b4c6980ad111513c16496

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Aberrant expression of PDZ-binding kinase/T-LAK cell-originated protein kinase modulates the invasive ability of human pancreatic cancer cells via the stabilization of oncoprotein c-MYC

Autor: Partha P. Banerjee, Leala Aljehane, Bhaskar Kallakury, Fuminori Sonahara, Joshua D. Brown-Clay, Charles P. Hinzman, Jose G. Trevino, Ajay Goel

Publikováno v: Carcinogenesis. 39(12)

High frequency of mortality in patients with pancreatic ductal adenocarcinoma (PDAC) is vastly associated with the invasive and metastatic nature of these cancer cells. Little is known about the factors involved in this invasive/metastatic process. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e91c4d2a5be4e0821d0beb49a4a0747
https://pubmed.ncbi.nlm.nih.gov/30165468

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Targeting the Root Cause of Cystic Fibrosis

Autor: Joshua Holcomb, Zhe Yang, Nicholas Spellmon, Chunying Li, Fei Sun, Leala Aljehane, Laura Trescott, Cathy Mcleod

Publikováno v: Current drug targets. 16(9)

Cystic Fibrosis (CF) is a serious genetic condition caused by CF transmembrane conductance regulator (CFTR) mutation. CF patients have shortened lifespan due to airway obstruction, infection, and end-stage lung failure. However, recent development in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d0d923c2f75e53f65332ca965f3e8e
https://pubmed.ncbi.nlm.nih.gov/25316272

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