Zobrazeno 1 - 10
of 522
pro vyhledávání: '"Leake, Mark"'
Autor:
Pei, Linsen, Xian, Yujia, Yan, Xiaodan, Schaefer, Charley, Syeda, Aisha H., Howard, Jamieson, Liao, Hebin, Bai, Fan, Leake, Mark C., Pu, Yingying
Membraneless droplets formed through liquid-liquid phase separation (LLPS) play a crucial role in mRNA storage, enabling organisms to swiftly respond to environmental changes. However, the mechanisms underlying mRNA integration and protection within
Externí odkaz:
http://arxiv.org/abs/2404.17873
Autor:
Shepherd, Jack W, Guilbaud, Sebastien, Zhou, Zhaokun, Howard, Jamieson, Burman, Matthew, Schaefer, Charley, Kerrigan, Adam, Steele-King, Clare, Noy, Agnes, Leake, Mark C
Biopolymer topology is critical for determining interactions inside cell environments, exemplified by DNA where its response to mechanical perturbation is as important as biochemical properties to its cellular roles. The dynamic structures of chiral
Externí odkaz:
http://arxiv.org/abs/2401.10087
Autor:
Leake, Mark C
Physics of Life research in the UK is proving to be transformative to scientific insight and translational impact, but challenges remain. Here I discuss its disruptive potential and the barriers to interdisciplinary research seen through the lens of
Externí odkaz:
http://arxiv.org/abs/2307.00003
Autor:
Payne-Dwyer, Alex, Kumar, Gaurav, Barrett, James, Gherman, Laura K., Hodgkinson, Michael, Plevin, Michael, Mackinder, Luke, Leake, Mark C., Schaefer, Charley
The condensation of Rubisco holoenzymes and linker proteins into 'pyrenoids', a crucial super-charger of photosynthesis in algae, is qualitatively understood in terms of 'sticker-and-spacer' theory. We derive semi-analytical partition sums for small
Externí odkaz:
http://arxiv.org/abs/2301.05681
Autor:
Fosado, Yair A. G., Howard, Jamieson, Weir, Simon, Noy, Agnes, Leake, Mark C, Michieletto, Davide
In spite of the nanoscale and single-molecule insights into how nucleoid associated proteins (NAPs) interact with DNA, their role in modulating the mesoscale viscoelasticity of the entangled genome in vivo has been overlooked so far. By combining mic
Externí odkaz:
http://arxiv.org/abs/2205.03510
Autor:
Leake, Mark C
Early Career Researcher (ECR) development is a dynamic challenge that tensions the urge to perform ground-breaking research against an ultimate practical aspiration of establishing an acceptable level of job security. There is no typical career path
Externí odkaz:
http://arxiv.org/abs/2204.13189