A Common Polymorphism in EC-SOD Affects Cardiopulmonary Disease Risk by Altering Protein Distribution

Autor: Hartney, John M, Stidham, Timothy, Goldstrohm, David A, Oberley-Deegan, Rebecca E, Weaver, Michael R, Valnickova-Hansen, Zuzana, Scavenius, Carsten, Benninger, Richard K P, Leahy, Katelyn F, Johnson, Richard, Gally, Fabienne, Kosmider, Beata, Zimmermann, Angela K, Enghild, Jan J, Nozik-Grayck, Eva, Bowler, Russell P

Publikováno v: Hartney, J M, Stidham, T, Goldstrohm, D A, Oberley-Deegan, R E, Weaver, M R, Valnickova-Hansen, Z, Scavenius, C, Benninger, R K P, Leahy, K F, Johnson, R, Gally, F, Kosmider, B, Zimmermann, A K, Enghild, J J, Nozik-Grayck, E & Bowler, R P 2014, ' A Common Polymorphism in EC-SOD Affects Cardiopulmonary Disease Risk by Altering Protein Distribution ', Circulation. Cardiovascular Genetics (Online), vol. 7, no. 6, pp. 659-666 . https://doi.org/10.1161/CIRCGENETICS.113.000504

BACKGROUND: -The enzyme extracellular superoxide dismutase (EC-SOD; SOD3) is a major antioxidant defense in lung and vasculature. A nonsynonomous single nucleotide polymorphism (SNP) in EC-SOD (rs1799895) leads to an arginine to glycine (Arg→Gly) a

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A Common Polymorphism in Extracellular Superoxide Dismutase Affects Cardiopulmonary Disease Risk by Altering Protein Distribution.

Autor: Hartney, John M., Stidham, Timothy, Goldstrohm, David A., Oberley-Deegan, Rebecca E., Weaver, Michael R., Valnickova-Hansen, Zuzana, Scavenius, Carsten, Benninger, Richard K.P., Leahy, Katelyn F., Johnson, Richard, Gally, Fabienne, Kosmider, Beata, Zimmermann, Angela K., Enghild, Jan J., Nozik-Grayck, Eva, Bowler, Russell P.

Publikováno v: Circulation: Cardiovascular Genetics; Oct2014, Vol. 7 Issue 5, p659-666, 8p