Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Leah V Sibener"'
Autor:
Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Publikováno v:
eLife, Vol 9 (2020)
T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet the degree of peptide specificity of Treg-cell function, and whether Treg ligands can be u
Externí odkaz:
https://doaj.org/article/901b336084904a38bd5004c2630ed0ff
Autor:
Bill Gates, Jeantine Lunshof, Hakim Yadi, Luhan Yang, Tomas de Wouters, Sajith Wickramasekara, Xavier Duportet, Michelle Mc Murray Heath, Heather Dewey-Hagborg, Emily M LeProust, Jake Sherkow, Eddie Martucci, George M. Church, Arturo Elizondo, Teresa Tarragó, Neri Oxman, Leah V. Sibener, J. Craig Venter, Aviv Regev, Abasi Ene-Obong, Katrine Bosley, Francesco Gatto, Sebastian Giwa, Veronika Oudova, Sharon F. Terry, Silvia Gold, Spin Wang, Priscilla Chan, Jason Mellad, Christopher Thomas Scott, Charlotte Casebourn, Janice Chen, Sarah Richardson, Michael Chen, Bowen Zhao, Jeremy Farrar, Jernej Godec, John Cumbers
Publikováno v:
Nature Biotechnology, 39(6), 654-660. Nature Publishing Group
Nature Biotechnology asks a selection of leaders from across biotech to look at the future of the sector and make some predictions for the coming years.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbf200877ba451ff54acacbe37f6aff
https://doi.org/10.1038/s41587-021-00941-4
https://doi.org/10.1038/s41587-021-00941-4
Autor:
Xiang Zhao, Elizabeth M. Kolawole, Waipan Chan, Yinnian Feng, Xinbo Yang, Marvin H. Gee, Kevin M. Jude, Leah V. Sibener, Polly M. Fordyce, Ronald N. Germain, Brian D. Evavold, K. Christopher Garcia
Publikováno v:
Science
Adoptive cell therapy using engineered T cell receptors (TCRs) is a promising approach for targeting cancer antigens, but tumor-reactive TCRs are often weakly responsive to their target ligands, peptide–major histocompatibility complexes (pMHCs). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d860002b6ad3e1c00b202f85ceddfbfb
https://doi.org/10.1126/science.abl5282
https://doi.org/10.1126/science.abl5282
Publikováno v:
Trends in Cancer. 6:299-318
The ideal cancer target antigen (Ag) is expressed at high copy numbers on neoplastic cells, absent on normal tissues, and contributes to the survival of cancer cells. Despite significant investments in the identification of cell surface Ags, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b71fa16b35b20becf46e52bdd914c5
https://doi.org/10.1016/j.trecan.2020.01.002
https://doi.org/10.1016/j.trecan.2020.01.002
Autor:
John D. Leonard, Alejandro Ramirez, Jason Romero, Jake Kleiner, Joanna Dreux, Bindu Hegde, Bryan Xie, Akshay Sharathchandra, Nathan Katz, Venita I. DeAlmeida, Hans-Peter Gerber, Marvin H. Gee, Leah V. Sibener
Publikováno v:
Cancer Research. 82:578-578
Peptide-HLA (pHLA)- targeting therapeutics, such as T cell receptor-engineered T cells (TCR-T), have had clinical success in treating solid tumors. However, challenges related to safety exist: major concerns remain surrounding the cross-reactivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b73cf224f999d7de80b7d553614fc9
https://doi.org/10.1158/1538-7445.am2022-578
https://doi.org/10.1158/1538-7445.am2022-578
Autor:
Gang Wang, Michael E. Birnbaum, Christina S. Savvides, Christophe Benoist, Caleb R. Glassman, Ricardo A. Fernandes, Eric Luxenberg, Shen Dong, Leah V. Sibener, K. Christopher Garcia, Diane Mathis, Xinbo Yang, Chaoran Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4086cb01aa964b12a60a398c209dd021
https://doi.org/10.7554/elife.58463.sa2
https://doi.org/10.7554/elife.58463.sa2
Autor:
Bill Gates, Charlotte Casebourn, Xavier Duportet, Sarah Richardson, Jake Sherkow, J. Craig Venter, Luhan Yang, Sajith Wickramasekara, Janice Chen, Aviv Regev, Sharon F. Terry, Tomas de Wouters, Abasi Ene-Obong, Heather Dewey-Hagborg, Jason Mellad, Eddie Martucci, Christopher Thomas Scott, Bowen Zhao, Arturo Elizondo, Francesco Gatto, Neri Oxman, Michael Chen, Veronika Oudova, Katrine Bosley, Emily M LeProust, Leah V. Sibener, Jernej Godec, Michelle Mc Murray Heath, Sebastian Giwa, John Cumbers, Hakim Yadi, Jeantine E. Lunshof, Jeremy Farrar, Silvia Gold, Spin Wang, Priscilla Chan, George M. Church, Teresa Tarragó
Publikováno v:
Nature Biotechnology. 39:1017-1017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6aab7a641fcde016d2a6a87d3d95a04
https://doi.org/10.1038/s41587-021-01000-8
https://doi.org/10.1038/s41587-021-01000-8
Publikováno v:
Biochemical pharmacology. 168
High-potency oncology compounds such as antibody- drug conjugates, T cell redirecting, and CAR-T cell therapies have provided transformational responses in patients with liquid tumors. However, they delivered only limited benefit to solid tumor patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fc20b38b41c05780fff116390cb99f
https://pubmed.ncbi.nlm.nih.gov/31323186
https://pubmed.ncbi.nlm.nih.gov/31323186
Autor:
Leah V. Sibener, Hunter B. Fraser, Jonathan K. Pritchard, Eilon Sharon, Alexis Battle, K. Christopher Garcia
Publikováno v:
Nature genetics
In each individual, a highly diverse T cell receptor (TCR) repertoire interacts with peptides presented by major histocompatibility complex (MHC) molecules. Despite extensive research, it remains controversial whether germline-encoded TCR-MHC contact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233b180bf8e6ae06dbd0f4cd4e4ff09b
https://doi.org/10.1038/ng.3625
https://doi.org/10.1038/ng.3625
Autor:
Caleb R. Glassman, K. Christopher Garcia, Leah V. Sibener, Michael E. Birnbaum, Juan L. Mendoza, Marvin H. Gee, Kevin Jude, Ricardo A. Fernandes, Xinbo Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(31)
T cell receptors (TCRs) bind to peptide-major histocompatibility complex (pMHC) with low affinity (Kd ∼ μM), which is generally assumed to facilitate cross-reactive TCR “scanning” of ligands. To understand the relationship between TCR/pMHC aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef1a7c67c8a47e0d2a8638429c61ea1
https://pubmed.ncbi.nlm.nih.gov/30021852
https://pubmed.ncbi.nlm.nih.gov/30021852